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Mostrando 421 - 440 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.80s Limitar resultados
  1. 421
    por Evans, Vyvyan
    Publicado 2016
    “…Hence, a linguistic system itself exhibits a bifurcation, in terms of the symbolic resources at its disposal. This design feature I dub the birfucation in linguistic organization. …”
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    Design Features for Linguistically-Mediated Meaning Construction: The Relative Roles of the Linguistic and Conceptual Systems in Subserving the Ideational Function of Language
  2. 422
    por Bodnar, Nicholas, Rapoport, Tom
    Publicado 2017
    “…ATP hydrolysis in the D1 domain is involved in substrate release from the Cdc48 complex, which requires the cooperation of the ATPase with a deubiquitinase (DUB). Surprisingly, the DUB does not completely remove all ubiquitin molecules; the remaining oligoubiquitin chain is also translocated through the pore. …”
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    Toward an understanding of the Cdc48/p97 ATPase
  3. 423
    “…Viruses have been increasingly identified that contain proteases possessing deubiquitinase (DUB) and/or deISGylase functions. This includes viruses in the Nairoviridae family that encode a viral homologue of the ovarian tumor protease (vOTU). vOTU activity was recently demonstrated to be critical for replication of the often-fatal Crimean-Congo hemorrhagic fever virus, with DUB activity suppressing the type I interferon responses and deISGylase activity broadly removing ISG15 conjugated proteins. …”
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    Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity
  4. 424
    “…USP9X is a conserved deubiquitinase (DUB) that regulates multiple cellular processes. …”
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    Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X
  5. 425
    “…Although several E3 ligases have been discovered to promote the ubiquitination of MCL1, the deubiquitinating enzyme (DUB) that regulates its stability requires further investigation. …”
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    The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein
  6. 426
    “…Despite the severe pulmonary toxicity noted with VLX1570, efforts directed at identifying DUB inhibitors with greater therapeutic indices appear warranted based on the unique mechanism of action, robustness of preclinical antitumor activity, and activity of the DUB inhibitors in MM resistant to PIs targeting the 20S proteasome subunit.…”
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    Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma
  7. 427
    “…The degradation of proteins by the multi-subunit proteasome complex is tightly regulated through a series of checkpoints, amongst which are a set of deubiquitinating proteases (DUBs). The proteasome-associated DUBs, UCH-L5 (Ubiquitin carboxyl-terminal hydrolase isozyme L5) and USP14 (Ubiquitin-specific protease 14), and the integral-DUB in the proteasome, Rpn11, is known to regulate proteasomal degradation by deubiquitination of distinct substrates. …”
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    Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor
  8. 428
    “…In this review, we discuss these issues in understanding deubiquitinating enzyme (DUB) function in head and neck squamous cell carcinoma (HNSCC), and their potential therapeutic strategies for HNSCC patients are also discussed.…”
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    The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma
  9. 429
    por Pearce, JD
    Publicado 2013
    “…Vast improvements in direct detection sensitivity combined with tantalizing hints from astrophysical data have lead some to dub the 2010's as the "Dark Matter Decade". Today collider based experiments, such as ATLAS and CMS, offer a new vantage point in the search for non-gravitational dark matter interactions. …”
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    “Dark matter searches” with a focus on new techniques (Mono-X)
  10. 430
    “…Inhibition of ER → lysosome Ca(2+) refilling by blockade of ER Ca(2+) exit channel using dantrolene or inhibition of SOCE using BTP2 inhibited lipotoxicity in vitro. Dantrolene or DUB also inhibited lipotoxic death of hepatocytes in vivo induced by administration of ethyl palmitate together with LPS. …”
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    Lysosomal Ca(2+) as a mediator of palmitate-induced lipotoxicity
  11. 431
    “…The remaining 18 patients had no structural causes and were categorized as cases of dysfunctional uterine bleeding (DUB). Increased ET was more commonly observed in postmenopausal patients (4.3%) compared to premenopausal patients (0.7%) among those with AUB, while the reverse was true for patients with DUB. …”
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    Endometrial Histopathology in Abnormal Uterine Bleeding and Its Relation With Thyroid Profile and Endometrial Thickness
  12. 432
    “…CONCLUSIONS: These results indicate that b-AP15 inhibits cell migration and induces apoptosis in GCB- and ABC-DLBCL cells, and suggest that inhibition of 19S proteasomal DUB should be a novel strategy for DLBCL treatment.…”
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    Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma
  13. 433
    “…In addition to its conventional papain-like protease activity, Lpro acts as a deubiquitinase (DUB) and deISGylase. In this study, we identified a conserved residue in Lpro that is involved in its interaction with ISG15. …”
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    Impairment of the DeISGylation Activity of Foot-and-Mouth Disease Virus Lpro Causes Attenuation In Vitro and In Vivo
  14. 434
    “…Methods: The expression of DUB related genes in macrophages (MΦs) was detected by reverse transcription-PCR. …”
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    USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer
  15. 435
    “…In particular, we identified USP29 as a critical deubiquitylase (DUB) of HIF1α, which directly deubiquitylates and stabilizes HIF1α and, thus, promotes its transcriptional activity. …”
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    USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis
  16. 436
    “…Thus, we analyzed twenty-three metals (Ca, Fe, Mg, Mn, Zn, Al, Ag, Ba, Co, Cr, Cu, Li, Ni, Tl, V, Mo, Pd, Pt, Sb, As, Pb, Cd, and Hg) in dried U. barbata lichen (dUB) by inductively coupled plasma mass spectrometry (ICP-MS). …”
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    Elemental Analysis and In Vitro Evaluation of Antibacterial and Antifungal Activities of Usnea barbata (L.) Weber ex F.H. Wigg from Călimani Mountains, Romania
  17. 437
    “…It has two enzymatic functions, a histone acetyltransferase (HAT) and a deubiquitinase (DUB) and plays a central role in processes such as transcription initiation, elongation, protein stability, and telomere maintenance. …”
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    SAGA Complex Subunits in Candida albicans Differentially Regulate Filamentation, Invasiveness, and Biofilm Formation
  18. 438
    “…PLpro moonlights as a deubiquitinating (DUB) and deISGylating enzyme, enabling adaptation of a DUB high throughput (HTS) screen to identify PLpro inhibitors. …”
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    Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
  19. 439
    “…Inspired by transverse-momentum and threshold resummation, we introduce additional scales, that we dub resummation scales, that can be varied to estimate the uncertainty on the evolution at any scale. …”
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    Emergence of resummation scales in the evolution of the QCD strong coupling and PDFs
  20. 440
    “…In this paper we show that SGGS decides the stratified fragment which generalizes EPR, the PVD fragment, and a new fragment that we dub restrained. The new class has the small model property, as the size of SGGS-generated models can be upper-bounded, and is also decided by hyperresolution and ordered resolution. …”
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    SGGS Decision Procedures
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