“…As political instruments, human rights can be challenged in two important ways: first, by undermining the claim to universality by appealing to a kind of cultural relativism, and second, by accusing human rights of unjustifiably imposing values that are not genuinely universal (which I dub the problem of parochialism). The human right to health is no exception. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The deubiquitinating enzyme (DUB) is the main practitioner of the reversal of ubiquitination. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We show that Cyclin G physically interacts and extensively co-localizes on chromatin with the conserved ETP Additional sex combs (ASX), belonging to the repressive PR-DUB complex that participates in H2A deubiquitination and Hox gene silencing. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The C239A and H351A mutations eliminated the deubiquitinase (DUB) activity of Et-OTU, whereas the D236A mutation did not. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: In the present study, we identified MINDY1, a DUB enzyme in the motif interacting with ubiquitin-containing novel DUB family, as a bona fide deubiquitylase of YAP in bladder cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Ubiquitination, which can be reversed by deubiquitinating enzymes (DUBs), plays important roles during brain development. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we consider a general class of dark matter candidates with characteristic masses and interaction cross-sections characterized in units of grams and cm$^2$, respectively -- we therefore dub these macroscopic objects as Macros. Such dark matter candidates could potentially be assembled out of Standard Model particles (quarks and leptons) in the early universe. …”
Enlace del recurso
Enlace del recurso

“…Ubiquitin-specific proteases (USPs) represent the largest family of deubiquitinating enzymes (DUB). These proteases cleave the isopeptide bond between ubiquitin and a lysine residue of a ubiquitin-modified protein. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To understand its physics, we compute ghost-mediated scatterings among matter particles at tree-level, finding a new power-like infra-red enhancement typical of 4-derivative theories, that we dub ‘ghostrahlung’. Super-Planckian scatterings get downgraded to Planckian by radiating hard gravitons and ghosts, which are weakly coupled and carry away the energy.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this review, we focus on the multiple functions of DUBs in RIG-I-like receptors (RLRs) and stimulator of interferon genes (STING)-mediated antiviral signaling pathways, oncoviruses regulation of NF-κB activation, oncoviral life cycle, and the potential of DUB inhibitors as therapeutic strategies.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The probe's reactivity has been demonstrated against recombinant DUBs and to capture endogenous DUB activity in cell lysate. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Chronic pain is regulated by ubiquitination, SUMOylation, ubiquitin ligase, and deubiquitinating enzyme (DUB), etc. Insight into the mechanism of the ubiquitin system regulating chronic pain might contribute to relevant therapeutic targets and the development of novel analgesics.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Hormonal imbalance is the main component involved in the pathogenesis of dysfunctional uterine bleeding (DUB). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We modified Ubl–NHNH(2) with various thiol-reactive electrophiles that couple selectively with E2s and DUBs. The ease of modification enables the rapid generation and screening of ubiquitin probes with various C-terminal truncations and warheads for the selection of the most suitable combination for a given E2 or DUB.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We look for renormalon effects leading to corrections of order Λ$_{QCD}$, that we dub “linear” renormalons, in the inclusive cross section (with and without selection cuts), in the mass of the reconstructed-top system, and in the average energy of the final-state W boson, considering both the pole and the $ \overline{\mathrm{MS}} $ scheme for the top mass. …”
Enlace del recurso
Enlace del recurso

“…Family with sequence similarity 188 member B (FAM188B) has been identified as a new deubiquitinase (DUB) member. Here, we demonstrate that FAM188B knockdown makes lung cancer cells sensitive to anoikis and inhibits lung metastasis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PRINCIPAL FINDINGS: In this study, we have identified OTUD5 as a DUB that interacts with and deubiquitinates p53. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We discuss the impact of those processes on tumourigenesis and potential therapeutic applications of DUBs for cancer treatment.…”
Enlace del recurso
Enlace del recurso

“…Deubiquitination via deubiquitinating enzymes (DUBs) has been emerged as one of the important post-translational modifications, resulting in the regulation of numerous target proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso