“…Although UCH-L1 is classed as a deubiquitinating enzyme (DUB) the direct functions of UCH-L1 remain enigmatic and a wide array of alternative functions has been proposed. …”
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“…Recently, we have found that USP35 acts as a deubiquitinating enzyme (DUB) for Aurora B and affects its stability during cell division, thus being involved in the regulation of mitosis. …”
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“…These MLM theorists, which we will dub ‘market moralists,’ all put forward a specific version of the argument that while the market is well suited to allocate some categories of goods and services, it is undesirable for the allocation of other such categories. …”
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“…Our studies demonstrate that a deubiquitinating enzyme (DUB) family member, USP37, can deubiquitinate Snail and prevent degradation of Snail. …”
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“…Keywords: Otubains, deubiquitylating enzymes, Ubiquitin, Ubiquitin-like proteins, interferon-stimulated genes, Ubiquitin processing enzymes, crystal structure, interferon stimulated genes, ISG15, DUB, OTU, poly-Ubiquitin chains, signal transduction, protein degradation, protein targeting.…”
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“…Sendlewski, who studied the corresponding fragment of Nelson algebras) we dub weakly pseudo-complemented quasi-Kleene algebras. …”
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“…This same variant was shown to selectively form covalent adducts with UCHL3 in MDA-MB-231 breast cancer cells and no reactivity toward other DUBs expressed. Overall, this study demonstrates the feasibility of the approach and also provides insight into how this approach may be applied to other DUB targets.…”
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“…The deubiquitination process removes ubiquitin molecules from the protein, which requires the participation of deubiquitinating enzymes (DUBs). Ubiquitin-specific protease 15 (USP15) is a DUB that participates in many biological cell processes and regulates tumorigenesis. …”
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“…While the origin of the pandemic in China led some, including former US president Donald Trump, to dub the pathogen “Chinese virus” and to support anti-Chinese conspiracy narratives, it caused Chinese state officials to openly support anti-US conspiracy theories about the “true” origin of the virus. …”
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“…Deubiquitinating enzymes (DUBs), comprising about five subfamily members, are key players in deubiquitination. …”
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“…Third, the more infectious people believe that COVID-19 is, the less willing they are to take protective measures, a finding we dub the “fatalism effect”. We develop a formal model that can explain the fatalism effect and discuss its implications for optimal policy during the pandemic.…”
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“…The counter-measure of activating the mitophagy pathway with deubiquitinase (DUB) inhibitors such as USP30 inhibitors is progressing in the clinic for kidney disease and the proof of biology for this target will be tested in these trials. …”
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“…USP7, a deubiquitinating enzyme (DUB), was found to be downregulated during hBMSC differentiation. …”
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“…Already, rapid diagnostic testing, phylogenetic surveillance, and real-time outbreak response provide just a few examples of molecular advances we dub “precision stewardship.” However, the AMR causal factors range from the molecular to that of global health policy. …”
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“…Standard platinum-based chemotherapy has a response rate of approximately 50%, but drug resistance develops after short-term treatment. Deubiquitinating (DUB) enzyme inhibitors increase protein polyubiquitination and endoplasmic reticulum (ER) stress, which might further suppress cancer stemness and overcome cisplatin resistance. …”
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“…Screening candidate DUBs from the human DUB library, we discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. …”
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“…Deubiquitinating enzymes (DUBs) have been increasingly implicated in regulation of cellular processes, but a functional role for Ubiquitin C-terminal Hydrolases (UCHs), which has been largely relegated to processing of small ubiquitinated peptides, remains unexplored. …”
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“…Importantly, this study reveals a novel role for a DUB in specifically promoting new protein synthesis.…”
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“…Linkage-specific human deubiquitinases (DUBs) are used to show that NleL generates heterotypic Ub chains, and branched chains are efficiently hydrolysed by DUBs. …”
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“…Here, we identified the deubiquitination enzyme (DUB) USP20 as a pivotal regulator of ATR-related DDR pathway. …”
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