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Mostrando 561 - 580 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.12s Limitar resultados
  1. 561
    “…Our work explains modularity in the BRCC36 DUB family, with different adaptor subunits conferring diversified targeting and regulatory functions.…”
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    Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation
  2. 562
    “…This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. …”
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    Distinct expression and prognostic value of OTU domain-containing proteins in non-small-cell lung cancer
  3. 563
    “…CONCLUSIONS: The proteasome DUB inhibitors b-AP15/VLX1570 are cell cycle-active. …”
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    Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
  4. 564
    “…In this study, using a functional screen of USPs siRNA library, we identified ubiquitin‐specific proteases USP10 as a deubiquitinating enzyme (DUB) that sustains the protein level of Smad4 and activates TGF‐β signaling. …”
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    Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein
  5. 565
    “…MicroRNA‐mediated modulations of DUBs in case of DENV infections have not been explored yet. …”
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    Dengue NS5 modulates expression of miR‐590 to regulate ubiquitin‐specific peptidase 42 in human microglia
  6. 566
    “…Here, we characterized the effects of the deubiquitinase (DUB) inhibitor VLX1570 on protein homeostasis, both at the level of the UPR and on protein translation, in acute lymphoblastic leukemia (ALL). …”
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    Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
  7. 567
    por Kang, Ji An, Jeon, Young Joo
    Publicado 2020
    “…Ubiquitin-specific protease 18 (USP18), originally referred to as UBP43, is a major DUB that reverses the PTM of target proteins by ISG15 (ISGylation). …”
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    Emerging Roles of USP18: From Biology to Pathophysiology
  8. 568
    “…In our current study, we identified a new deubiquitination enzyme USP1 through screening the whole DUB (Deubiquitinases) siRNA library. The expression of USP1 is elevated in human breast cancer compared with normal mammary tissues. …”
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    The deubiquitinating enzyme USP1 modulates ERα and modulates breast cancer progression
  9. 569
    “…Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed by the Polycomb group (PcG) repressive complex 1 (PRC1) and reversed by the PcG-repressive deubiquitinase (PR-DUB)/BAP1 complex. Here we critically assess the current knowledge regarding H2Aub deposition and removal, its crosstalk with PcG repressive complex 2 (PRC2)-mediated histone H3K27 methylation, and the recent attempts toward discovering its readers and solving its enigmatic functions. …”
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    Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
  10. 570
    “…ASXL proteins activate BAP1 by forming the polycomb repressive deubiquitinase (PR-DUB) complex which acts on H2AK119ub1. Besides the ASXL proteins, BAP1 is known to interact with an established set of additional proteins. …”
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    Proteomic analysis identifies novel binding partners of BAP1
  11. 571
    “…We demonstrate, theoretically and empirically, that our target-independent approach to inference, which we dub “universal adaptability,” is competitive with target-specific approaches that rely on propensity scoring. …”
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    Universal adaptability: Target-independent inference that competes with propensity scoring
  12. 572
    “…Proteins containing JAB1/MPN/MOV34 metalloenzyme (JAMM/MPN(+)) domains that have Zn(2+)-dependent deubiquitinase (DUB) activity are ubiquitous across among all domains of life. …”
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    DRJAMM Is Involved in the Oxidative Resistance in Deinococcus radiodurans
  13. 573
    “…Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) belonging to the USP subfamily, which was found localized in the mitochondrial outer membrane and peroxisomes owing to its unique transmembrane domain. …”
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    USP30: Structure, Emerging Physiological Role, and Target Inhibition
  14. 574
    “…We have developed and characterized a novel tool for ubiquitin detection and purification based on OtUBD, a high-affinity ubiquitin-binding domain (UBD) derived from an Orientia tsutsugamushi deubiquitylase (DUB). We demonstrate that OtUBD can be used to purify both monoubiquitylated and polyubiquitylated substrates from yeast and human tissue culture samples and compare their performance with existing methods. …”
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    A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins
  15. 575
    por Hill, Jake, Nyathi, Yvonne
    Publicado 2022
    “…Overexpression of SGTA promotes deubiqutination of MLPs resulting in their accumulation in cytosolic inclusions, suggesting SGTA acts in collaboration with deubiquitinating enzymes (DUBs) to exert these effects. However, the DUBs that play a role in this process have not been identified. …”
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    USP5 enhances SGTA mediated protein quality control
  16. 576
    “…Here, we explicate a class of proteins that contain both transmembrane and peripheral domains, which we dub transmembrane membrane readers (TMMRs). Their transmembrane and peripheral elements anchor them to one bilayer and reversibly attach them to another section of bilayer, respectively, positioning them to tether and fuse membranes while recognizing signals such as phosphoinositides (PIs) and modifying lipid chemistries in proximity to their transmembrane domains. …”
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    Transmembrane Membrane Readers form a Novel Class of Proteins That Include Peripheral Phosphoinositide Recognition Domains and Viral Spikes
  17. 577
    “…SCA3 results from abnormal polyQ expansion in the deubiquitinase (DUB), ataxin-3 (Atxn3). To understand the role of the different domains of mutant Atxn3 on its pathogenicity, with the hope that they can be explored for therapeutic interventions, we have systematically studied their individual and collective effects on its toxicity. …”
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    Ubiquitin-binding site 1 of pathogenic ataxin-3 regulates its toxicity in Drosophila models of Spinocerebellar Ataxia Type 3
  18. 578
    por Dynel, Marta, Zappavigna, Michele
    Publicado 2023
    “…The discursive effects of this interplay of voices entail imitation, parody, mockery and irony on the micro level, while on the interactional (macro) level, anti-conspiracy tweets jointly enact what we dub “polyvocal scorn”. It expresses multiple users’ trenchant critique and contempt for conspiracy theories, while the humour of the tweets serves to display the users’ wit and superiority over conspiracy theorists.…”
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    Enacting polyvocal scorn in #CovidConspiracy tweets: The orchestration of voices in humorous responses to COVID-19 conspiracy theories
  19. 579
    “…Hence, in this work, we borrow methods from the theory of entanglement in many-body quantum systems to introduce a subsystem measure of symmetry breaking that we dub entanglement asymmetry. As a prototypical illustration, we study the entanglement asymmetry in a quantum quench of a spin chain in which an initially broken global U(1) symmetry is restored dynamically. …”
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    Entanglement asymmetry as a probe of symmetry breaking
  20. 580
    “…As the Young elements are RetroElements and the cells are excluded from the developmental process, we dub these REject cells. With these and ICM being characterised by differential mobile element activities, the human embryo may be a “selection arena” in which one group of cells selectively die, while other less damaged cells persist.…”
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    A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass
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