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Mostrando 41 - 60 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.13s Limitar resultados
  1. 41
    “…The recent emergence of the roles of TNF receptor-associated factor (TRAFs) and deubiquitinating enzymes (DUBs) superfamily in hypertrophic cardiomyopathy has enhanced our knowledge. …”
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    Emergence of Members of TRAF and DUB of Ubiquitin Proteasome System in the Regulation of Hypertrophic Cardiomyopathy
  2. 42
    “…Here, we review the HH-associated DUBs, discussing the consequences of deubiquitylation on the maintenance of the HH pathway activity and its implication in tumorigenesis. …”
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    DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer
  3. 43
    “…An emerging target in the development of cancer therapeutics are the deubiquitinase (DUB) enzymes that remove ubiquitin from protein substrates. …”
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    The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer
  4. 44
    por Li, Sixuan, Zhang, Hongquan, Wei, Xiaofan
    Publicado 2021
    “…DUBs have emerged as promising prognostic indicators and drug targets. …”
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    Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery
  5. 45
    “…Furthermore, KLF4 promoted DUB3 transcription by binding to the DUB3 promoter. …”
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    DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma
  6. 46
    “…This challenge has motivated the authors to focus on complementary metal oxide semiconductor silicon on insulator micro electro-mechanical system (CMOS-SOI-MEMS) technologies, and the result is a new pellistor-like sensor, dubbed GMOS, with integrated signal processing. In this study, we describe the performance of such sensors for the selective detection of mixtures of gases. …”
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    Selective Sensing of Mixtures of Gases with CMOS-SOI-MEMS Sensor Dubbed GMOS
  7. 47
    “…Treatment with sub-optimal doses of DUB and lysosome inhibitors synergistically kills TNBC cells. …”
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    Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells
  8. 48
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    Dub3 controls DNA damage signalling by direct deubiquitination of H2AX
  9. 49
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    Corrigendum: Emergence of Members of TRAF and DUB of Ubiquitin Proteasome System in the Regulation of Hypertrophic Cardiomyopathy
  10. 50
    “…Using these models, a multiplex RT-PCR system for DUB genes was applied to identify biomarkers by comparing expression patterns and DUB mRNA levels; multiplex RT-PCR results were validated by qRT-PCR and Western blotting analyses. …”
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    Differential Expression of DUB Genes in Ovarian Cells Treated with Di-2-Ethylhexyl Phthalate
  11. 51
    “…We describe recent advances and discuss future directions in reagent development for studying DUBs.…”
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    Catching a DUB in the act: novel ubiquitin-based active site directed probes
  12. 52
    “…The deubiquitination of histone H2A on lysine 119 by 2A-DUB/MYSM1, BAP1, USP16, and other enzymes is required for key cellular processes, including transcriptional activation, apoptosis, and cell cycle control, during normal hematopoiesis and tissue development, and in tumor cells. …”
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    Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors
  13. 53
    por Dai, Xiaoming, Liu, Jing, Wei, Wenyi
    Publicado 2020
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    DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma
  14. 54
    “…DUB3/ubiquitin-specific protease 17 (USP17) is a type of DUB that has attracted much attention in cancer research. …”
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    The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review
  15. 55
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    An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity
  16. 56
    “…Ovarian tumor domain (OTU)-containing deubiquitinating enzymes (DUBs) are an essential DUB to maintain protein stability in plants and play important roles in plant growth development and stress response. …”
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    Genome-Wide Identification and Gene Expression Analysis of the OTU DUB Family in Oryza sativa
  17. 57
    “…We also found that DUB1 expression was elevated in gastric cancer and that elevated DUB1 expression correlated with TAZ activation and poor survival. …”
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    DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer
  18. 58
    por Tsefou, Eliona, Ketteler, Robin
    Publicado 2022
    “…In this review, we highlight the role of deubiquitinating enzymes (DUBs) in the regulation of mitophagy. We summarise the current knowledge on DUBs that regulate mitophagy as drug targets and provide a list of small molecule inhibitors that are valuable tools for the further development of therapeutic strategies targeting the mitophagy pathway in neurodegeneration.…”
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    Targeting Deubiquitinating Enzymes (DUBs) That Regulate Mitophagy via Direct or Indirect Interaction with Parkin
  19. 59
    Tesis Electrónico eBook
    Cultural differences and similarities between the original and the mexican dubbed version of Disney’s “The legend of Sleepy Hollow” /
  20. 60
    “…Loss of the HAT module due to deletion of the SWIRM domain decreases the H2B deubiquitinating activity of SAGA, indicating a role for the HAT module in regulating SAGA DUB module activity. A model of the HAT module created with Alphafold Multimer provides insights into the structural basis for our biochemical data, as well as prior deletion studies.…”
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    The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module
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