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Mostrando 581 - 600 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.11s Limitar resultados
  1. 581
    “…Ubiquitin-ligase-initiated proteasomal degradation as well as its prevention by deubiquitinases (DUBs) are supposed to contribute to the above-mentioned disturbances. …”
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    USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1α but Not HIF-2α Protein Synthesis
  2. 582
    “…Deubiquitinases (DUBs) are an essential component of the ubiquitin-proteasome system (UPS). …”
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    USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer
  3. 583
    “…USP18 can also provide a negative feedback by inhibiting JAK–STAT signalling through protein interactions independently of DUB activity. Here, we provide an acute example of this phenomenon, whereby the early expression of USP18, post-interferon treatment of HCT116 colon cancer cells is sufficient to fully suppress the expression of the ISG15 E1 enzyme, UBA7. …”
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    ISGylation-independent protection of cell growth by USP18 following interferon stimulation
  4. 584
    “…RESULTS: While identifying putative ubiquitin specific protease (USP) enzymes that contain a conserved Asp (I) domain in humans, 4 USP17 subfamily members, highly homologous to DUB-3, have been found (USP17K, USP17L, USP17M, and USP17N), from human chorionic villi. …”
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    Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability
  5. 585
    “…RESULTS: We have cloned and expressed 22 human DUBs, representing the major clades of the USP protease family. …”
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    Screen for ISG15-crossreactive Deubiquitinases
  6. 586
    “…USP25m is the muscle isoform of the deubiquitinating (DUB) enzyme USP25. Similarly to most DUBs, data on USP25 regulation and substrate recognition is scarce. …”
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    The UBA-UIM Domains of the USP25 Regulate the Enzyme Ubiquitination State and Modulate Substrate Recognition
  7. 587
    “…BACKGROUND: OTUB1 is a member of OTUs (Ovarian-tumor-domain-containing proteases), a deubiquitinating enzymes family (DUBs), which was shown as a proteasome-associated DUB to be involved in the proteins Ub-dependent degradation. …”
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    OTUB1 Overexpression in Mesangial Cells Is a Novel Regulator in the Pathogenesis of Glomerulonephritis through the Decrease of DCN Level
  8. 588
    “…Machado-Joseph disease (MJD) or Spinocerebellar Ataxia type 3 is caused by a polyglutamine-encoding CAG expansion in the ATXN3 gene, which encodes a 42 kDa deubiquitinating enzyme (DUB), ataxin-3. We investigated ataxin-3 deubiquitinating activity and the functional relevance of ataxin-3 interactions with two proteins previously described to interact with ataxin-3, hHR23A and valosin-containing protein (VCP/p97). …”
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    Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3
  9. 589
    “…To computationally characterize potential enzymes in eukaryotes, we constructed 1, 1, 15 and 6 hidden Markov model (HMM) profiles for E1s, E2s, E3s and DUBs at the family level, separately. Moreover, the ortholog searches were conducted for E3 and DUB families without HMM profiles. …”
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    UUCD: a family-based database of ubiquitin and ubiquitin-like conjugation
  10. 590
    “…FINDINGS: Here, we performed an unbiased siRNA library screen targeting the DUBs encoded by the human genome to uncover new regulators of TCR-mediated NF-κB activation. …”
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    Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
  11. 591
    “…Ataxin-3 is the first deubiquitinating enzyme (DUB) reported to be activated by mono-ubiquitination. …”
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    Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3()
  12. 592
    “…Our study revealed a leukaemia inhibitor factor (Lif) dependent not-canonical pluripotency signature (AF067063, BC061212, Dub1, Eif1a, Gm12794, Gm13871, Gm4340, Gm4850, Tcstv1/3, and Zfp352), that specifically marks Zscan4 ESCs' fluctuation. …”
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    Identification of a Novel Gene Signature of ES Cells Self-Renewal Fluctuation through System-Wide Analysis
  13. 593
    “…Proteasomes function under tonic inhibitory conditions, possibly via the ubiquitin chain-trimming function of USP14, a proteasome-associated deubiquitinating enzyme (DUB). We identified three specific RNA aptamers of USP14 (USP14-1, USP14-2, and USP14-3) that inhibited its deubiquitinating activity. …”
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    Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity
  14. 594
    “…Ubiquitin specific protease 35 (USP35) is a member of deubiquitylases (DUBs). It remains largely unknown about the biological role and the regulation mechanism of USP35. …”
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    USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2
  15. 595
    por Elliott, Paul R., Komander, David
    Publicado 2015
    “…While the assembly machinery, the linear ubiquitin chain assembly complex (LUBAC), and receptors for this ubiquitin chain type have been known for years, it was less clear which deubiquitinating enzymes (DUBs) hydrolyse Met1 linkages specifically. In 2013, two labs reported the previously unannotated protein FAM105B/OTULIN to be this missing Met1 linkage‐specific DUB. …”
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    Regulation of Met1‐linked polyubiquitin signalling by the deubiquitinase OTULIN
  16. 596
    “…Here, we describe the function of one of these, the deubiquitinase (DUB) USP47. We found that USP47 acts post-translationally to counteract a proteasome-mediated event that reduces MAPK half-life and thereby dampens signaling output. …”
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    The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila
  17. 597
    “…As a deubiquitinating enzyme (DUB), the physiological substrates of ataxin-3 (ATX-3) remain elusive, which limits our understanding of its normal cellular function and that of pathogenic mechanism of spinocerebellar ataxia type 3 (SCA3). …”
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    The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53
  18. 598
    “…This study represents, to the best of our knowledge, the first report suggesting DUB-mediated target protein stabilization that is independent of its deubiquitinase activity. …”
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    Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity
  19. 599
    “…This study has identified zinc pyrithione, an FDA-approved pharmacological agent with potential antitumor properties as a proteasomal DUB inhibitor.…”
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    Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases
  20. 600
    “…Deubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. …”
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    Revealing a Novel Otubain-Like Enzyme from Leishmania infantum with Deubiquitinating Activity toward K48-Linked Substrate
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