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Mostrando 601 - 620 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.49s Limitar resultados
  1. 601
    “…We demonstrate that BAP1 deubiquitinase activity and its association with ASXL1 to form the Polycomb repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism. …”
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    Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells
  2. 602
    “…Although approximately 100 deubiquitinating enzymes (DUBs) are encoded in the human genome, very little is known about the DUBs that function in mitosis. …”
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    USP35 regulates mitotic progression by modulating the stability of Aurora B
  3. 603
    “…Here, we show that CPX induced the degradation of Cdc25A neither by increasing CK1α or decreasing DUB3 expression, nor via activating GSK3β, but through activating Chk1 in rhabdomyosarcoma (Rh30) and breast carcinoma (MDA-MB-231) cells. …”
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    Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation
  4. 604
    “…In contrast with yeast and metazoan DUB modules that are associated with the large SAGA complex, the Arabidopsis DUBm only comprises three proteins (hereafter named SGF11, ENY2 and UBP22) and appears to act independently as a major H2Bub deubiquitinase activity. …”
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    DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis
  5. 605
    “…TRAIL treatment in cancer cells reduced the activity and cleavage of USP5, a deubiquitinase (DUB) previously shown to target unanchored Ub polymers and regulate p53-mediated transcription. …”
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    Tumor necrosis factor related apoptosis inducing ligand (TRAIL) regulates deubiquitinase USP5 in tumor cells
  6. 606
    “…We show that Tra1 contributes to the overall integrity of NuA4, whereas, within SAGA, it specifically controls the incorporation of the de-ubiquitination module (DUB), as part of an ordered assembly pathway. Biochemical and functional analyses reveal the mechanism by which Tra1 specifically interacts with either SAGA or NuA4. …”
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    Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast
  7. 607
    “…Next, we discuss how these methods help understanding the ubiquitin conjugation–deconjugation system by recent advances in ubiquitin ligase probes and diubiquitin-based DUB probes. Lastly, we discuss how these methods help studying post-translational modification of ubiquitin itself.…”
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    Synthetic and semi-synthetic strategies to study ubiquitin signaling
  8. 608
    “…Far-field excitation and detection of this high-momenta mode become possible with our resonator design that can boost the coupling efficiency via virtual polariton modes with image charges that we dub ‘image polaritons’. Using these image polaritons, we experimentally observe a record-high effective index of up to 132 and quality factors as high as 501. …”
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    Image polaritons in boron nitride for extreme polariton confinement with low losses
  9. 609
    “…Ubiquitylation is a form of Post-Translational Modification (PTM): addition of a ubiquitin to the chain is catalyzed by E3 ligases, and removal of ubiquitin is catalyzed by a De-UBiquitylating enzyme (DUB). Nearly four decades ago, Goldbeter and Koshland discovered that reversible PTM cycles function like on-off switches when the substrates are at saturating concentrations. …”
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    Crosstalk and ultrasensitivity in protein degradation pathways
  10. 610
    “…Two E3 ubiquitin ligases, Hrd1 and Doa10, are known to mediate the proteasomal degradation of 3-hydroxy-3-methylglutaryl-CoA reductase Hmg2 and squalene epoxidase Erg1 with accumulation of the toxic sterols in cells, but the deubiquitinases (DUBs) involved are unclear. Here, we screened for DUBs responsible for sterol homeostasis using yeast strains from a DUB-deletion library. …”
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    Deubiquitinase Ubp3 enhances the proteasomal degradation of key enzymes in sterol homeostasis
  11. 611
    “…The UPS is composed of multiple components, including a series of enzymes (E1, E2, E3, and deubiquitinase [DUB]) and 26S proteasome (19S regulatory particles + 20S core particle). …”
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    Targeting Ubiquitin–Proteasome System With Copper Complexes for Cancer Therapy
  12. 612
    “…Strikingly, acceptance of alkyne substituents is strictly DUB-specific as this is not conserved among members of the same subfamily. …”
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    Exploring the Versatility of the Covalent Thiol–Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease
  13. 613
    “…Inhibition of deubiquitinases (DUBs) with chemical inhibitors or blocking UCHL5 DUB expression with small interfering RNA (siRNA) abrogated NLRP3 inflammasome assembly and activation. …”
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    Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells
  14. 614
    “…This process is known to be mediated by various deubiquitinating enzymes (DUBs) in order to control the protein’s half-life and its expression levels among many other signaling processes. …”
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    Synthesis and Evaluation of Ubiquitin–Dioxetane Conjugate as a Chemiluminescent Probe for Monitoring Deubiquitinase Activity
  15. 615
    “…We cloned full-length cDNAs encoding a family of 58 ubiquitin-specific deubiquitinating enzymes (DUBs), also known as ubiquitin-specific proteases (USPs). …”
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    USP37 Deubiquitinates CDC73 in HPT-JT Syndrome
  16. 616
    “…PcG complexes include PRC1, PRC2 and PR-DUB which are responsible for the control of the histone modifications H2AK119ub1 and H3K27me3. …”
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    Know when to fold ‘em: Polycomb complexes in oncogenic 3D genome regulation
  17. 617
    “…Deubiquitylases (DUBs) are therapeutically amenable components of the ubiquitin machinery that stabilize substrate proteins. …”
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    The OTUD6B‐LIN28B‐MYC axis determines the proliferative state in multiple myeloma
  18. 618
    “…Our findings underscore the challenge this perception disconnects poses to understanding and anticipating public responses to long-term growth strategies and policies. We dub this unique cultural fatalism “the Mioritic Syndrome.”…”
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    The Perception of Economic Growth and the Romanian “Mioritic Syndrome”
  19. 619
    “…Also, we aimed to determine whether Degrasyn is more effective in terms of anti-cancer activity compared to the non-selective DUB inhibitor PR-619. To facilitate the translational value of the obtained results, our experiments were performed using both human and canine in vitro models of BC. …”
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    Ubiquitin-Specific Proteases as Potential Therapeutic Targets in Bladder Cancer—In Vitro Evaluation of Degrasyn and PR-619 Activity Using Human and Canine Models
  20. 620
    “…As a consequence of this choice, we obtain a type of content-theoretic notion of ignorance, which is essentially different from the traditional approach. We dub it severe ignorance. We axiomatize, prove completeness and decidability for the logic of reflexive (three-valued) Kripke frames, which we find the most suitable candidate for our novel proposal and, finally, compare our approach with the most traditional one.…”
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    A Logical Modeling of Severe Ignorance
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