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Mostrando 701 - 720 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.44s Limitar resultados
  1. 701
    “…Recently, much effort has been put to identify specific de-ubiquitinating enzymes (DUBs) that oppose Parkin in the ubiquitination of its targets. …”
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    Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson’s Disease
  2. 702
    “…Here we show that a subset of the natural lytic phage population, which we dub “superspreaders,” releases substantial amounts of intact, transformable plasmid DNA upon lysis, thereby promoting horizontal gene transfer by transformation. …”
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    Novel “Superspreader” Bacteriophages Promote Horizontal Gene Transfer by Transformation
  3. 703
    “…b-AP15 and its derivatives block proteasome deubiquitinase (DUB) activity and have been developed and tested in the clinic as potential cancer therapeutic agents. b-AP15 induces apoptosis in cancer cells, but the underlying mechanisms are largely undefined. …”
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    The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5
  4. 704
    “…Notably, the most common mechanism for OA is not Gold, Green, or Hybrid OA, but rather an under-discussed category we dub Bronze: articles made free-to-read on the publisher website, without an explicit Open license. …”
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    The state of OA: a large-scale analysis of the prevalence and impact of Open Access articles
  5. 705
    “…Moderate overexpression of MCPIP1 protected insulin-secreting INS1E cells against cytokine toxicity by a mechanism dependent on the presence of the PIN/DUB domain in MCPIP1. It also reduced cytokine-induced Chop and C/ebpβ expression and maintained MCL-1 expression. …”
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    MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity
  6. 706
    “…Abbreviations: Bafilomycin/BafA: bafilomycin A(1); DUB: deubiquitinating enzyme; iPSC: induced pluripotent stem cells; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; nt: non-targeting; PD: Parkinson disease; p-ATG13: phospho-ATG13; PtdIns3P: phosphatidylinositol 3-phosphate; RPS6: ribosomal protein S6; SNPs: single nucleotide polymorphisms; TH: tyrosine hydroxylase; USP24: ubiquitin specific peptidase 24…”
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    The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability
  7. 707
    “…Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. …”
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    The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer
  8. 708
    “…A family of reagents has been developed that specifically label deubiquitylating enzymes (DUBs) and facilitate characterization of their inhibitors. …”
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    Detection of ubiquitin–proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development()
  9. 709
    “…Here, we evaluated the host transcriptional response to infection with murine coronaviruses encoding independent mutations in one of two different viral antagonists, the deubiquitinase (DUB) within nonstructural protein 3 or the endoribonuclease (EndoU) within nonstructural protein 15. …”
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    Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages
  10. 710
    “…Ubiquitin-specific protease (USP) is a type of deubiquitinating enzyme (DUB) that has been implicated in numerous cancers, including colorectal, myeloma and breast. …”
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    Knockdown of ubiquitin-specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc-finger E-box binding homeobox 1
  11. 711
    “…OBJECTIVES: Targeting the deubiquitinases (DUBs) has become a promising avenue for anti‐cancer drug development. …”
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    Inhibition of deubiquitination by PR‐619 induces apoptosis and autophagy via ubi‐protein aggregation‐activated ER stress in oesophageal squamous cell carcinoma
  12. 712
    “…Thus, this study identifies HECTD1 as a mammalian E3 ligase that assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages.…”
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    The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1
  13. 713
    “…These substrates include UCHL1 and UCHL5, where N-terminal ubiquitination distinctly alters deubiquitinase (DUB) activity. This work describes an antibody toolkit for enrichment and global profiling of endogenous N-terminal ubiquitination sites, while revealing functionally relevant substrates of UBE2W.…”
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    Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
  14. 714
    “…Recently, deubiquitinating enzymes (DUBs) has been reported as potential cancer therapy targets due to their multifunctions involved in the regulation of tumorigenesis, cell cycle, apoptosis, and autophagy. …”
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    USP5 Sustains the Proliferation of Glioblastoma Through Stabilization of CyclinD1
  15. 715
    “…Deubiquitinases (DUBs) regulate diverse biological processes and represent a novel class of drug targets. …”
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    USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10
  16. 716
    “…Sun-exposed skin (zygomatic region) and non-exposed oral mucosa of the lower lip were assessed using HFU (DUB(®) cutis, Taberna Pro Medicum) with a 22 MHz probe. …”
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    High-Frequency Ultrasound Assessment of Skin and Oral Mucosa in Metabolic Syndrome Patients—A Cross-Sectional Study
  17. 717
    “…An engineering strategy that optimizes lifetime contrast led to a biosensor that shows a 3-fold change in the calcium-dependent quantum yield and a fluorescence lifetime change of 1.3 ns. We dub the biosensor Turquoise Calcium Fluorescence LIfeTime Sensor (Tq-Ca-FLITS). …”
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    A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium
  18. 718
    “…Unlike traditional phase-contrast techniques, this new method, which we dub dynamic inflow magnitude contrast (DIMAC), does not require velocity-encoding gradients as sensitivity to flow velocity is derived purely from the inflow effect. …”
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    Measuring Arterial Pulsatility With Dynamic Inflow Magnitude Contrast
  19. 719
    “…AB 5968, dilution 1:250, rabbit, Abcam, United Kingdom) and matrix metallopeptidase 2 (MMP-2, code-Nr. DUB 03, dilution 1:100, goat) expressions were detected by immunohistochemical staining. …”
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    Pulsed Radiofrequency Increases Nestin and Matrix Metalloproteinase-2 Expression in Porcine Lumbar Dorsal Root Ganglion
  20. 720
    “…Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and represent an emerging therapeutic paradigm in cancer. …”
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    USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
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