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  1. 61
    por Hamilton, Kirk L.
    Publicado 2012
    “…This perspective highlights a multi-prong technologies approach that uses three novel technologies (BLAP-tagged proteins, TUBES, and DUB-Chips) that can rapidly identify a number of potential candidates that modulate ubiquitylation and deubiquitylation of cellular proteins.…”
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    BLAP-Tags, TUBEs and DUB-Chips: Combined Novel Technologies will Advance Molecular Epithelial Physiology
  2. 62
    “…These data provide the first explanation of how an inactive pseudo DUB allosterically activates a cognate DUB partner, and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity, subcellular localization, and biological function.…”
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    Higher -Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function
  3. 63
    “…Therefore, DUBs involved in these processes emerge as potentially critical targets for the treatment of not only hematological, but potentially also solid tumors.…”
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    DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets
  4. 64
    “…IL-6 also stabilizes Snail1 by inducing Dub3 expression, the specific inhibitor WP1130 binds to Dub3 and inhibits the Dub3-mediating Snail1 stabilization in vitro and in vivo. …”
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    Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
  5. 65
    “…Altogether, our results suggest that Cyclin G, PRC1 and PR-DUB cooperate for developmental stability.…”
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    Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability
  6. 66
    “…Changes in the function and abundance of certain E3 ligases or DUBs involved in T cell homeostasis are associated with the development of autoimmune diseases. …”
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    Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response
  7. 67
    “…In summary, NXN suppressed the proliferation and metastasis of HCC by inhibiting DUB3-mediated deubiquitylation of Snail protein. …”
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    NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3
  8. 68
    “…Cylindromatosis (CYLD) is known as an important tumor suppressor in various human cancers, and a deubiquitination enzyme (DUB) as well. Previously, we identified Skp2 as an E3 ligase of Aurora B ubiquitination, but the DUB of Aurora B still remains unknown. …”
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    A Tumor Suppressive Role of CYLD as a Novel Potential DUB of Aurora B in Cervical Cancer
  9. 69
    “…Unexpectedly, the specific H2AK119 deubiquitylation complex composed by additional sex comb‐like proteins and BAP1 has also been genetically characterized as Polycomb repressive deubiquitnase (PR‐DUB) for unclear reasons. However, it remains a mystery whether and how PR‐DUB deficiency affects chromatin states and cell fates through impaired PcG silencing. …”
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    PR‐DUB safeguards Polycomb repression through H2AK119ub1 restriction
  10. 70
    “…Mechanistically, we identify a deubiquitinase, DUB3, as a target of CDK4/6; CDK4/6-mediated activation of DUB3 is essential to deubiquitinate and stabilize SNAIL1, a key factor promoting epithelial–mesenchymal transition and breast cancer metastasis. …”
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    CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
  11. 71
    “…According to recent findings, the histone H2A deubiquitinase 2A-DUB/Mysm1 interacts with the p53-axis in hematopoiesis and tissue differentiation in mice, in part by modulating DNA-damage responses in stem cell and progenitor compartments. …”
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    MYSM1/2A-DUB is an epigenetic regulator in human melanoma and contributes to tumor cell growth
  12. 72
    “…One plausible mechanism of Slug and Twist stabilization involves removal of ubiquitin by deubiquitinases (DUBs). In this study, we identified Dub3 as a novel DUB for both Slug and Twist. …”
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    Stabilization of the transcription factors slug and twist by the deubiquitinase dub3 is a key requirement for tumor metastasis
  13. 73
    “…Furthermore, overexpression of Mcl-1 or DUB3 inhibited apoptosis by PTC596. Taken together, our findings reveal that the inhibition of BMI-1 induces Mcl-1 destabilization through downregulation of DUB3, resulting in the induction of cancer cell death.…”
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    Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
  14. 74
    por Qiao, Hui, Tian, Yuan, Huo, Yuda, Man, Heng-Ye
    Publicado 2022
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    Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice
  15. 75
    “…In contrast to the PRCs, the Polycomb repressive deubiquitinase (PR-DUB) complex removes H2AK119ub1 from chromatin through the action of the C-terminal hydrolase BAP1. …”
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    RINGs, DUBs and Abnormal Brain Growth—Histone H2A Ubiquitination in Brain Development and Disease
  16. 76
    “…As a novel Hippo pathway regulator, DUB3 has the potential to act a tumor suppressor by limiting YAP activity.…”
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    DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins
  17. 77
    “…In summary, this investigation uncovers a role for 2A-DUB/Mysm1 in suppression of p53-mediated inhibitory programs during epidermal development.…”
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    2A-DUB/Mysm1 Regulates Epidermal Development in Part by Suppressing p53-Mediated Programs
  18. 78
    Publicado 1849
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    Dr. Charles H. Dubs' Patent Compound Union Screw Forceps. Dr. S. P. Hullihen's Root Forceps
  19. 79
    “…Proteasomal deubiquitinase (DUB) is an important constituent in the UPS and has proved to be a novel anticancer target. …”
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    Autophagy Induced by Proteasomal DUB Inhibitor NiPT Restricts NiPT-Mediated Cancer Cell Death
  20. 80
    “…Dysfunctions of many DUBs reportedly cause various diseases; therefore, DUBs are considered as important drug targets, although the biochemical characteristics and cellular functions of many DUBs are still unclear. …”
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    A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors
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