“…Both DUBs are recruited to DSBs where they actively remove RNF168-induced ubiquitin conjugates. …”
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“…These two DUBs can trim tetraubiquitin with K46 and K63 linkages in vitro. …”
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“…Ubiquitin carboxyl-terminal hydrolases (UCHs) belong to an enzymatic subclass of DUBs, and are represented by three members in Arabidopsis, UCH1, UCH2 and UCH3. …”
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“…The trabecular thickness and number increased, while the trabecular separationwas reduced slightly in DSBS than in DUBS (P>0.05). The BMD and BMC increased significantly (P<0.05), while the compressive strength only increased slightly in DSBS than in DUBS (P>0.05). …”
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“…Physicists at the SPring-8 accelerator in Hyogo, Japan, have discovered a particle made of five quarks. It has been dubbed the pentaquark or theta-plus (1/2 page).…”
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“…Here, we review key deubiquitylating enzymes (DUBs) involved in DDR pathways, and describe how targeting DUBs may lead to selective therapies to treat cancer patients.…”
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“…The choice of DNA-repair pathway when RNF8- and RNF168-mediated ubiquitination-dependent DDR signaling is negatively regulated by deubiquitinating enzymes (DUBs) is reviewed to clarify how the opposing roles of RNF8/RNF168 and DUBs regulate ubiquitination-dependent DDR signaling and the choice of DNA-repair pathway.…”
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“…This is a second part of the paper presenting a miniature, combustion-type gas sensor (dubbed GMOS) based on a novel thermal sensor (dubbed TMOS). …”
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“…Deubiquitinating enzymes (DUBs) are a group of proteases that are important for maintaining cell homeostasis by regulating the balance between ubiquitination and deubiquitination. …”
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“…In 1973, Ralph Steinman and Zanvil Cohn discovered an unusual looking population of cells with an unprecedented ability to activate naive T cells. Dubbed “dendritic cells,” these cells are now known as the primary instigators of adaptive immunity.…”
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“…This review was motivated by accumulating evidence that a series of E3 ligases and deubiquitinases (DUBs) finely target multiple signaling pathways, transcription factors and key enzymes to govern the functions of almost all components of the TME. …”
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“…Recently, studies have highlighted the participation of DUBs in deubiquitinating PD-L1 and modulating its expression. …”
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“…We show increased total activity of deubiquitinating enzymes (DUBs) in human macrophages after infection, while confirm reduced enzymatic activities of two specific DUBs (USP10 and UCH-L5), and demonstrate increased activity of USP25. …”
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“…In this review, we provide an overview of how DUBs emerge in pathogen-induced pulmonary inflammation and related aspects in ALI/ARDS. …”
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“…Hence, herpesviruses have evolved ways to antagonize the host defense mechanisms by targeting UPS components such as ubiquitin E3 ligases and deubiquitinases (DUBs) that establish a productive infection. This review delineates how herpesviruses usurp the critical roles of ubiquitin E3 ligases and DUBs in innate immune response to escape host-antiviral immune response, with particular focus on retinoic acid-inducible gene I (RIG-I)-like receptors (RLR), cyclic-GMP-AMP (cGAMP) synthase (cGAS), stimulator of interferon (IFN) genes (STING) pathways, and inflammasome signaling.…”
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“…In this review, we focus on the role of different DUBs on mitophagy and their contribution to NAFLD, NASH, alcohol‐related liver disease, and especially HCC.…”
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“…"The California Institute of Technology has revealed details of a system dubbed Fast TCP that it says could potentially lead to movies being down- loaded over the web in under 5 seconds" (1/2 page).…”
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“…We propose a locomotion framework for bipedal robots consisting of a new motion planning method, dubbed trajectory optimization for walking robots plus (TOWR+), and a new whole-body control method, dubbed implicit hierarchical whole-body controller (IHWBC). …”
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“…Interestingly, a few deubiquitinating enzymes (DUBs) additionally modulate these two pathways negatively or positively. …”
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“…After introducing a simplified way to implement particle mixings, we present a new class of FeynRules functions allowing both for the analytical computation of all the model mass matrices and for the generation of a C++ package, dubbed ASperGe. This program can then be further employed for a numerical evaluation of the rotation matrices necessary to diagonalize the field basis. …”
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