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Mostrando 901 - 920 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.12s Limitar resultados
  1. 901
    por Dubs, Charles H.
    Publicado 1851
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    Successful Operation on, and Treatment of, a Disease of Antrum Highmorianum of the Right Side
  2. 902
    “…However the precise mechanism by which these DUBs act on TβR function remains poorly defined. …”
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    USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination
  3. 903
    “…Ubiquitin-specific protease 42 (USP42) is a member of deubiquitinating enzymes (DUBs). The alterations of DUBs are implicated in the pathogenesis of a wide variety of tumors. …”
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    Overexpression and Biological Function of Ubiquitin-Specific Protease 42 in Gastric Cancer
  4. 904
    “…Recently, deubiquitinating enzymes (DUBs) are emerging as new regulators in cancer progression. …”
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    Suppression of Ubiquitin-Specific Peptidase 17 (USP17) Inhibits Tumorigenesis and Invasion in Non-Small Cell Lung Cancer Cells
  5. 905
    “…In this review, we discuss the importance of molecular chaperones and DUBs in reducing the severity of PKU and HT1 by stabilizing and rescuing mutant proteins.…”
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    Protein Degradation and the Pathologic Basis of Phenylketonuria and Hereditary Tyrosinemia
  6. 906
    “…Key viral strategies to evade RLR signaling include direct targeting of ubiquitin E3 ligases, active deubiquitination using viral deubiquitinating enzymes (DUBs), and the upregulation of cellular DUBs that regulate RLR signaling. …”
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    Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylation
  7. 907
    “…Deubiquitinating enzymes (DUBs) remove ubiquitin from target proteins and play a critical role in maintaining protein homeostasis. …”
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    The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study
  8. 908
    “…Protein modification by ubiquitin is one of the most versatile posttranslational regulations and counteracted by almost 100 deubiquitinating enzymes (DUBs). USP8 was originally identified as a growth regulated ubiquitin-specific protease and is like many other DUBs characterized by its multidomain architecture. …”
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    Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions
  9. 909
    “…To understand the factors that prevent MSX1 protein degradation, the identification of deubiquitinating enzymes (DUBs) for MSX1 is essential. In this study, we performed loss-of-function-based screening for DUBs regulating MSX1 protein levels using the CRISPR/Cas9 system. …”
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    Genome-Wide CRISPR/Cas9-Based Screening for Deubiquitinase Subfamily Identifies Ubiquitin-Specific Protease 11 as a Novel Regulator of Osteogenic Differentiation
  10. 910
    “…BACKGROUND: As deubiquitinases (DUBs), ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to play a crucial role in regulating diverse biological processes. …”
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    UCHL1 Promoted Polarization of M1 Macrophages by Regulating the PI3K/AKT Signaling Pathway
  11. 911
    “…Deubiquitinating enzymes (DUBs) regulate numerous cellular functions by removing ubiquitin modifications. …”
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    OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways
  12. 912
    “…Deubiquitinases (DUBs) play important roles in various human cancers and targeting DUBs is considered as a novel anticancer therapeutic strategy. …”
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    Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells
  13. 913
    por Alonso, Rodrigo, Urbano, Alfredo
    Publicado 2017
    “…There exist non-trivial stationary points of the Euclidean action for an axion particle minimally coupled to Einstein gravity, dubbed wormholes. They explicitly break the continuos global shift symmetry of the axion in a non-perturbative way, and generate an effective potential that may compete with QCD depending on the value of the axion decay constant. …”
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    Wormholes and masses for Goldstone bosons
  14. 914
    “…Our general implementation, dubbed smeft@nlo, covers all types of operators: bosonic and two- and four-fermion ones. …”
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    Automated one-loop computations in the SMEFT
  15. 915
    “…We revisit the proposal that the ensemble average over free boson CFTs in two dimensions — parameterized by Narain’s moduli space — is dual to an exotic theory of gravity in three dimensions dubbed U(1) gravity. We consider flavored partition functions, where the usual genus g partition function is weighted by Wilson lines coupled to the conserved U(1) currents of these theories. …”
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    Adding Flavor to the Narain Ensemble
  16. 916
    “…Herein, we introduce a new and robust technique dubbed phase modulated rotary resonance (PMRR) for reintroducing heteronuclear dipolar couplings while suppressing all other interactions under a broad range of MAS conditions. …”
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    Accurate heteronuclear distance measurements at all magic-angle spinning frequencies in solid-state NMR spectroscopy
  17. 917
    Publicado 2006
    “…"After decades of intensive effort by both experimental and theoretical physicists worldwide, a tiny particle with no charge, a very low mass and a lifetime much shorter than a nanosecond, dubbed the "axion", has now been detected by the University at Buffalo physicist who first suggested its existence in a little-read paper as early as 194." (2 pages)…”
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    Long the fixation of physicists worldwide, a tiny particle is found
  18. 918
    “…The most potent compound inhibits PLpro with k(inact)/K(I) = 9,600 M(−1) s(−1), achieves sub-μM EC(50) values against three SARS-CoV-2 variants in mammalian cell lines, and does not inhibit a panel of human deubiquitinases (DUBs) at >30 μM concentrations of inhibitor. An X-ray co-crystal structure of the compound bound to PLpro validates our design strategy and establishes the molecular basis for covalent inhibition and selectivity against structurally similar human DUBs. …”
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    Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
  19. 919
    por De Cesare, Virginia
    Publicado 2023
    “…The removal of ubiquitin is orchestrated by a network of about 100 deubiquitylating enzymes (DUBs). Many cellular processes are tightly controlled by ubiquitylation, which is essential in maintaining cellular homeostasis. …”
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    MALDI-TOF Mass Spectrometry for interrogating ubiquitin enzymes
  20. 920
    “…Fusion proteins in which all seven lysines of wild-type ubiquitin were retained while the site cleaved by cytosolic deubiquitinating enzymes (DUBs) was removed were nontoxic, apparently due to rapid ubiquitination and proteasomal degradation. …”
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    Anthrax Toxin-Mediated Delivery of the Pseudomonas Exotoxin A Enzymatic Domain to the Cytosol of Tumor Cells via Cleavable Ubiquitin Fusions
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