“…Deubiquitinating enzymes (DUBs) play key roles in ubiquitin–proteasome system. …”
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“…By overexpressing a panel of deubiquitinating enzymes (DUBs), we found that USP17 and USP4 efficiently deubiquitinate PDGF receptor β (PDGFRβ) and are able to remove both Lys63 and Lys48-linked polyubiquitin chains from the receptor. …”
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“…We also highlight specific E3 ligases, DUBs, and chaperones, discussing possible strategies modulating protein degradation to target cancer drug resistance. …”
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“…We identify a new instability in electrostatic actuators dubbed quasi-static pull-in. We report experimental evidence of the instability and study its characteristics in two types of micro actuators operating in ambient air. …”
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“…In this Synopsis, we introduce the so-dubbed dyedauxiliary group strategy by focusing on arylazo sulfones that are bench stable and visible-light responsive derivatives of anilines that have been exploited as precursors of a wide range of intermediates, including carbon-centered radicals as well as aryl cations.…”
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“…The reaction takes place at the −NH(2) groups of nucleobases, and the resulting nucleosides are equipped with a sulfamoyl fluoride moiety, dubbed SuFNucs. These species undergo a selective sulfur fluoride exchange (SuFEx) reaction with various amines, leading to sulfamide-functionalized derivatives of adenosine, guanosine, and cytidine (SulfamNucs). …”
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“…The second type, and rarest is the 122 key model M which has 24 extra keys at the very top, dubbed the “programmers keyboard”. IBM manufactured these keyboards until 1991. …”
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“…The researchers were able to create genetic mutations by inserting foreign DNA into host DNA without leaving a trace of the foreign DNA. Dubbed "Delitto Perfetto," Italian for "perfect murder," the new technique leaves behind no clue that foreign DNA was introduced to engineer the desired genetic changes. …”
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“…The majority of women presenting with the disease are asymptomatic and it has been dubbed the “silent killer”. To date there is no effective minimally invasive method of stratifying those with the disease or screening for the disease in the general population. …”
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“…The dysregulation of the DUBs may give rise to the occurrence and development of tumors. …”
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“…The system comprises the ubiquitin conjugation machinery consisting of an enzyme cascade of E1, E2, and E3 enzymes, the deubiquitinases (DUBs) and the proteasome, a multisubunit protease complex acting through an N-terminal threonine protease mechanism. …”
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“…Deubiquitinases (DUBs) have important biological functions, but their roles in breast cancer metastasis are not completely clear. …”
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“…Deubiquitinating enzymes (DUBs) serve to maintain cellular homeostasis via protein ubiquitination and exert diverse regulatory functions in cancers and other diseases. …”
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“…The book may contain new image enhancements to After Effects, 64-bit versions of Illustrator and Flash Professional, and a new tool, dubbed Helium, that will enable designers to create content using HTML5 and…”
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“…The latter notion generalizes the idea of an irreducible symplectic manifold, dubbed an irreducible hyperkähler manifold in differential geometry, to possibly singular spaces. …”
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“…This talk reviews some of the fundamental concepts of gravitational waves and the methodology employed for their observation. The first event, dubbed GW150914, and the properties of its source, as inferred from the observation, will be discussed. …”
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“…Two extension operators (dubbed zero and leg operators, respectively) will play a major role in our analysis. …”
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“…Intense mate competition favors the evolution of extraordinary mating strategies such as the ability of males to identify premature females that are close to becoming mature and associate with them until they are sexually receptive (dubbed precopulatory mate guarding). Owing to possible take-overs by rival males, precopulatory guarding is a high-risk, time- and energy-intensive strategy. …”
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“…We have generated activity-based probes based on all seven isopeptide-linked diubiquitin topoisomers and demonstrated their structural integrity and ability to label DUBs in a linkage-specific manner.…”
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