“…Interestingly, one of the reversible covalent BTK PROTACs based on poseltinib with a rigid linker, dubbed as PS-RC-1, is highly potent (IC(50) = ~10 nM) in Mino cells but not in other mantle cell lymphoma (MCL) cell lines, such as Jeko-1 and Rec-R cells. …”
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“…Number theory, which Carl-Friedrich Gauss famously dubbed the queen of mathematics, has always been considered a very beautiful field of mathematics, producing lovely results and elegant proofs. …”
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“…A novel Monolithic Active Pixel Sensor based on 180 nm TowerJazz CMOS imaging technology, dubbed MALTA, has been designed to meet the radiation hardness requirements (1.5x10$^{15}$ 1 MeV $n_{eq}$/cm$^{2}$) of the outer barrel layers of the ITk Pixel detector. …”
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“…We postulate that a middle ground, dubbed LOHC (low-risk-open and high-risk-closed), is likely favorable, precluding obviously irrational HOLC (high-risk-open and low-risk-closed). …”
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“…The Canadian physiologist PA Stewart advanced the theory that the proton concentration, and hence pH, in any compartment is dependent on the charges of fully ionized and partly ionized species, and on the prevailing CO(2 )tension, all of which he dubbed independent variables. Because the kidneys regulate the concentrations of the most important fully ionized species ([K(+)], [Na(+)], and [Cl(-)]) but neither CO(2 )nor weak acids, the implication is that it should be possible to ascertain the renal contribution to acid–base homeostasis based on the excretion of these ions. …”
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“…We will also reveal methodologies that have been used to identify E3 ligases or DUBs to facilitate the search for yet-to-be discovered ubiquitin-mediated regulatory mechanisms in mTOR signaling. …”
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“…In this paper, we propose a twin-branch architecture (dubbed SiamOT) to mitigate the above problem in existing Siamese networks, wherein one branch is a classical Siamese network, and the other branch is an online training branch. …”
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“…Although the biochemical regulation of TBK1 activation has been studied, little is known about how enterovirus 71 (EV71) employs the deubiquitinases (DUBs) to regulate TBK1 activation for viral immune evasion. …”
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“…This activity, although rudimentary, bears resemblance to that of adenylate kinase (a P-loop NTPase enzyme). The polypeptides, dubbed as “P-loop prototypes”, thus relate to contemporary P-loop NTPases in terms of their sequence and function, and yet, given their simplicity, serve as plausible representatives of the early “founder enzymes” involved in proto-metabolic pathways.…”
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“…However, the role of deubiquitinating enzymes (DUBs) in bone resorption is still not well defined. …”
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“…Recent research has identified and dubbed a novel regulatory cell death modality—”cuprotosis”—wherein copper ions bind to acylated proteins in the tricarboxylic acid cycle of mitochondrial respiration, resulting in protein aggregation, subsequent downregulation of iron-sulfur cluster protein expression, induction of proteotoxic stress, and eventual cell death. …”
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“…Systemic use of doxycycline is known to sometimes cause a non-immune chemical thyroiditis, dubbed as black thyroid due to the intense black discoloration of the thyroid. …”
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“…It is well‐documented that about 10% of patients properly treated with antibiotics never fully recover, but instead go on to develop a chronic illness dubbed, posttreatment Lyme disease syndrome (PTLDS) characterized by severe fatigue, cognitive slowing, chronic pain, and sleep difficulties. …”
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“…Hence, unlike most existing works that homogeneously treat and integrate all cells, we propose a multi-omics data integration method (dubbed scBridge) that integrates cells in a heterogeneous manner. …”
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“…On the other hand, chiral materials are also known to exhibit chirality-dependent spin transmission, commonly dubbed “chirality induced spin selectivity” or CISS. …”
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“…Since the scanning time is proportional to the radiation dose imparted to the sample, this method can be used to increase the field of view of tomographic microscopy instruments while optimizing the radiation dose for radiation-sensitive samples and keeping the quality of the tomographic dataset on the required level. This approach, dubbed wide-field synchrotron radiation tomographic microscopy, can increase the lateral field of view up to five times. …”
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“…This peptide was then dubbed Cilengitide and is currently developed as drug by the company Merck-Serono (Germany). …”
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“…The number of distinct visual elements that can be simultaneously processed at a glance (dubbed the visual attention span), predicts single-word reading speed in both normal reading and dyslexic children. …”
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