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4por Pérez Carballo, María MonserrathRepositorio institucional.
Publicado 2015
Tesis Electrónico eBook -
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8“…Yang et al. discovered that HBX19818, an inhibitor of the deubiquitinase (DUB) USP10, leads to the dual degradation of spleen tyrosine kinase (SYK) and FLT3, resulting in death of AML cells.…”
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10por Gjonaj, Lorina, Sapmaz, Aysegul, Flierman, Dennis, Janssen, George M. C., van Veelen, Peter A., Ovaa, Huib“…In recent years, research has focused on deubiquitinating enzymes (DUBs) as potential therapeutic candidates in various diseases. …”
Publicado 2019
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11“…The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a plethora of processes carried out inside the cell by protein ubiquitination. …”
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12por Zhao, Jie, Guo, Jinhui, Wang, Yanan, Ma, Qiancheng, Shi, Yu, Cheng, Feng, Lu, Qiliang, Fu, Wen, Ouyang, Guangxiong, Zhang, Ji, Xu, Qiuran, Hu, Xiaoge“…The reversible process of ubiquitination is called de-ubiquitination: it is the process of re-releasing ubiquitinated substrates with the participation of de-ubiquitinases (DUBs) and other active substances. There is growing evidence that many dysregulations of DUBs are associated with tumorigenesis. …”
Publicado 2022
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13por González Zavala, Melisa MontserratRepositorio institucional.
Publicado 2017
Tesis Electrónico eBook -
14por Krutauz, Daria, Reis, Noa, Nakasone, Mark A., Siman, Peter, Zhang, Daoning, Kirkpatrick, Donald S., Gygi, Steven P., Brik, Ashraf, Fushman, David, Glickman, Michael H.“…Processing of lysine-48 and lysine-63 linkages by other deubiquitinating enzymes (DUBs) was also inhibited. Disruption of ubiquitin-dependent degradation by extended ubiquitin variants may therefore be attributed to their inhibitory effect on select DUBs, thus shifting research efforts related to protein accumulation in neurodegenerative processes from proteasomes to DUBs.…”
Publicado 2014
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15“…Here, we will review the current understanding of DUBs implicated in the control of hypoxia-inducible factor, the regulation of DUBs by hypoxia, and the use of DUB-specific drugs to target tumor hypoxia-signaling.…”
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16por Dubiel, Wolfgang, Chaithongyot, Supattra, Dubiel, Dawadschargal, Naumann, Michael“…Considering its intrinsic DUB activity specific for deneddylation of CRLs and belonging to the JAMM family as well as its associated DUBs, the CSN represents a multi-DUB complex. …”
Publicado 2020
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17por Kessler, Benedikt M.Enlace del recurso
Publicado 2021
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18“…ROS-mediated oxidation of the catalytic cysteine (Cys) of DUBs, leading to their reversible inactivation, has emerged as a key mechanism regulating DUB-controlled cellular events. …”
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19“…Here, we report on the deubiquitination enzymes (DUBs) and their ubiquitin-modified substrates and signaling pathways involved in melanoma progression. …”
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