Mostrando 1 - 20 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.14s Limitar resultados
  1. 1
    por Tolentino Cruz, Ana María
    Publicado 2018
    Tesis Electrónico eBook
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  3. 3
    por Cázares Castro Miryam Carolina
    Publicado 2014
    Repositorio institucional
    Tesis Electrónico eBook
  4. 4
    Repositorio institucional.
    Tesis Electrónico eBook
  5. 5
    por Rivas Ruiz, Carlos
    Publicado 2019
    Tesis Electrónico eBook
  6. 6
    por Cortèz Quintas, Gala
    Publicado 2021
    Tesis Electrónico eBook
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  8. 8
    por Cremer, Anjali, Stegmaier, Kimberly
    Publicado 2020
    “…Yang et al. discovered that HBX19818, an inhibitor of the deubiquitinase (DUB) USP10, leads to the dual degradation of spleen tyrosine kinase (SYK) and FLT3, resulting in death of AML cells.…”
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  10. 10
    “…In recent years, research has focused on deubiquitinating enzymes (DUBs) as potential therapeutic candidates in various diseases. …”
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  11. 11
    por Li, Ying, Reverter, David
    Publicado 2021
    “…The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a plethora of processes carried out inside the cell by protein ubiquitination. …”
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    “…The reversible process of ubiquitination is called de-ubiquitination: it is the process of re-releasing ubiquitinated substrates with the participation of de-ubiquitinases (DUBs) and other active substances. There is growing evidence that many dysregulations of DUBs are associated with tumorigenesis. …”
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    “…Processing of lysine-48 and lysine-63 linkages by other deubiquitinating enzymes (DUBs) was also inhibited. Disruption of ubiquitin-dependent degradation by extended ubiquitin variants may therefore be attributed to their inhibitory effect on select DUBs, thus shifting research efforts related to protein accumulation in neurodegenerative processes from proteasomes to DUBs.…”
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  15. 15
    por Schober, Amelie S., Berra, Edurne
    Publicado 2016
    “…Here, we will review the current understanding of DUBs implicated in the control of hypoxia-inducible factor, the regulation of DUBs by hypoxia, and the use of DUB-specific drugs to target tumor hypoxia-signaling.…”
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  16. 16
    “…Considering its intrinsic DUB activity specific for deneddylation of CRLs and belonging to the JAMM family as well as its associated DUBs, the CSN represents a multi-DUB complex. …”
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    “…ROS-mediated oxidation of the catalytic cysteine (Cys) of DUBs, leading to their reversible inactivation, has emerged as a key mechanism regulating DUB-controlled cellular events. …”
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    “…Here, we report on the deubiquitination enzymes (DUBs) and their ubiquitin-modified substrates and signaling pathways involved in melanoma progression. …”
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