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421por Buchholz, Anna, Vattai, Aurelia, Fürst, Sophie, Vilsmaier, Theresa, Zati Zehni, Alaleh, Steger, Alexander, Kuhn, Christina, Schmoeckel, Elisa, Dannecker, Christian, Mahner, Sven, Jeschke, Udo, Heidegger, Helene H.“…CONCLUSIONS: This study shed first light on EP1 expression in vulvar carcinoma. EP1 expression correlated significantly with the grading of the tumor, suggesting that it influences cell differentiation. …”
Publicado 2022
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422por Lushington, Ryan, Camilli, Samuel, Pascual, Francisco, Lockey, Richard F., Kolliputi, Narasaiah“…Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. …”
Publicado 2023
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423por Africa, Pasquale Claudio, Piersanti, Roberto, Regazzoni, Francesco, Bucelli, Michele, Salvador, Matteo, Fedele, Marco, Pagani, Stefano, Dede’, Luca, Quarteroni, Alfio“…[Formula: see text] -ep employs the monodomain equation to model the heart’s electrical activity. …”
Publicado 2023
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424por Budge, Mariana, Opara, Ijeoma, Weser, Veronica U., Sands, Brandon E., Hieftje, Kimberly D.“…Preexposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) prevention is approved for use in adolescents, though uptake remains low. …”
Publicado 2023
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425por Benmerah, Alexandre, Lamaze, Christophe, Bègue, Bernadette, Schmid, Sandra L., Dautry-Varsat, Alice, Cerf-Bensussan, Nadine“…To explore the role of Eps15 and the function of AP-2/Eps15 association in endocytosis, the Eps15 binding domain for AP-2 was precisely delineated. …”
Publicado 1998
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426por Confalonieri, Stefano, Salcini, Anna Elisabetta, Puri, Claudia, Tacchetti, Carlo, Di Fiore, Pier Paolo“…We mapped Tyr 850 as the major in vivo tyrosine phosphorylation site of Eps15. A phosphorylation-negative mutant of Eps15 acted as a dominant negative on the internalization of the EGFR, but not of the TfR. …”
Publicado 2000
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427por van Bergen en Henegouwen, Paul MP“…It is proposed that Eps15 and its family members Eps15R and Eps15b are involved in the regulation of membrane morphology, which is required for intracellular vesicle formation and trafficking.…”
Publicado 2009
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428por Denzel, Sabine, Maetzel, Dorothea, Mack, Brigitte, Eggert, Carola, Bärr, Gabriele, Gires, Olivier“…For the case of contact-inhibited cells, although cleavage of EpCAM occurred, nuclear translocation of EpICD was reduced, as were EpCAM effects. …”
Publicado 2009
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429“…We have previously shown that a Glossina-specific, immunoresponsive molecule, tsetse EP protein, is up regulated by the fly in response to gram-negative microbial challenge. …”
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430por Gostner, Johanna M, Fong, Dominic, Wrulich, Oliver A, Lehne, Florian, Zitt, Marion, Hermann, Martin, Krobitsch, Sylvia, Martowicz, Agnieszka, Gastl, Guenther, Spizzo, Gilbert“…BACKGROUND: Recently, EpCAM has attracted major interest as a target for antibody- and vaccine-based cancer immunotherapies. …”
Publicado 2011
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431por Spizzo, Gilbert, Fong, Dominic, Wurm, Martin, Ensinger, Christian, Obrist, Peter, Hofer, Carina, Mazzoleni, Guido, Gastl, Guenther, Went, Philip“…EpCAM expression frequently correlates with more aggressive tumour behaviour and new EpCAM-specific therapeutic agents have recently been approved for clinical use in patients with cancer. …”
Publicado 2011
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432por Luschnig-Schratl, Petra, Sturm, Eva M., Konya, Viktoria, Philipose, Sonia, Marsche, Gunther, Fröhlich, Eleonore, Samberger, Claudia, Lang-Loidolt, Doris, Gattenlöhner, Stefan, Lippe, Irmgard Th., Peskar, Bernhard A., Schuligoi, Rufina, Heinemann, Akos“…The involvement of the EP4 receptor was substantiated by a selective EP4 antagonist, which reversed the inhibitory effects of PGE(2) and the EP4 agonist. …”
Publicado 2011
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433“…The large difference in observed EPS production may be accounted for by consistently higher photochemical efficiency of photosystem II in the large (0.5) vs. small (∼0.35) strains. …”
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434“…As reviewed here, the EP1, EP2, and EP4 receptors, but not the EP3 receptor, contribute to NMSC development, albeit through different signaling pathways and with somewhat different outcomes. …”
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435por Sapienza, Karen, Sale, Stewart, Hague, Angela, Hart, Ian R, Marshall, John F, Thomas, Gareth JEnlace del recurso
Publicado 2010
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436por Pehl, Michael J., Jamieson, William David, Kong, Karen, Forbester, Jessica L., Fredendall, Richard J., Gregory, Glenn A., McFarland, Jacob E., Healy, Jessica M., Orwin, Paul M.“…BACKGROUND: Variovorax paradoxus is an aerobic soil bacterium associated with important biodegradative processes in nature. We use V. paradoxus EPS to study multicellular behaviors on surfaces. …”
Publicado 2012
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437“…The large variety of biological functions governed by prostaglandin (PG) E(2) is mediated by signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse strains with genetic ablation of each EP receptor subtype and the development of selective EP agonists and antagonists have tremendously advanced our understanding of PGE(2) as a physiologically and clinically relevant mediator. …”
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438por Mohan, Shekher, Glushakov, Alexander V., deCurnou, Alexander, Narumiya, Shuh, Doré, Sylvain“…Although hemin-mediated neurotoxicity has been linked to the production of free radicals and glutamate excitotoxicity, the role of the prostaglandin E(2) (PGE(2))-EP1 receptor remains unclear. Activation of the EP1 receptor in neurons results in increased intracellular calcium levels; therefore, we hypothesize that the blockade of the EP1 receptor reduces hemin neurotoxicity. …”
Publicado 2013
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439por Gorsic, Lidija K., Stark, Amy L., Wheeler, Heather E., Wong, Shan S., Im, Hae K., Dolan, M. Eileen“…We used EPS8 RNA interference to determine the effect of decreased EPS8 expression on LCL and A549 lung cancer cell sensitivity to cisplatin. …”
Publicado 2013
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440por Yang, Guang-xia, Xu, Yu-yin, Fan, Ya-ping, Wang, Jing, Chen, Xiao-lan, Zhang, Yi-de, Wu, Jian-hua“…We generated EP4(Flox/Flox) and EP4(+/−) mice, cultured primary WT, EP4(Flox/Flox) and EP4(+/−) GMCs, AD-EP4 transfected WT GMCs (EP4 overexpression) and AD-Cre transfected EP4(Flox/Flox) GMCs (EP4 deleted). …”
Publicado 2014
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