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  1. 1221
    “…Here, we report the effects of the highly potent EP4 antagonist ASP7657 on the DC population in tumor and antitumor immune activation in an immunocompetent mouse tumor model. …”
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    Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy
  2. 1222
    “…Here, we show that Abi1 (also known as E3b1) recruits PI3K, via p85, into a multimolecular signaling complex that includes Eps8 and Sos-1. The recruitment of p85 to the Eps8–Abi1–Sos-1 complex and phosphatidylinositol 3, 4, 5 phosphate (PIP3), the catalytic product of PI3K, concur to unmask its Rac-GEF activity in vitro. …”
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    Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1
  3. 1223
    “…Ep-CAM interacts with the LAIR molecules through its first epidermal growth factor domain; Ep-CAM–specific antibodies can abrogate the binding. …”
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    The Epithelial Cellular Adhesion Molecule (EP-Cam) Is a Ligand for the Leukocyte-Associated Immunoglobulin-like Receptor (Lair)
  4. 1224
    “…Prostaglandin E(2)-induced FasL expression was mediated by signalling via the EP1 receptor. Moreover, immunohistochemical analysis using serial sections of human colon adenocarcinomas revealed a strong positive correlation between COX-2 and FasL (r=0.722; P<0.0001) expression, and between EP1 receptor and FasL (r=0.740; P<0.0001) expression, in the tumour cells. …”
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    Prostaglandin E(2) stimulates Fas ligand expression via the EP1 receptor in colon cancer cells
  5. 1225
    por Maaser, K, Borlak, J
    Publicado 2008
    “…Expression of the epithelial cell adhesion molecule EpCAM is upregulated in a variety of carcinomas. …”
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    A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators
  6. 1226
    “…In the title trichodermin compound (systematic name: 12,13-ep­oxy­trichothec-9-en-4β-yl 4-fluoro­benzoate), C(22)H(25)FO(4), the five-membered ring displays an envelope conformation, whereas the two six-membered rings show the different conformations, viz. chair and half-chair. …”
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    Trichodermin (12,13-ep­oxy­trichethec-9-en-4β-yl 4-fluoro­benzoate)
  7. 1227
    “…Furthermore, all three MAbs were found to affect both Aap expression and extracellular polymeric substance (EPS, including extracellular DNA and PIA) biosynthesis in S. epidermidis and enhance the cell accumulation. …”
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    Monoclonal Antibodies against Accumulation-Associated Protein Affect EPS Biosynthesis and Enhance Bacterial Accumulation of Staphylococcus epidermidis
  8. 1228
    “…BACKGROUND: To specifically deliver paclitaxel (PTX) to retinoblastoma (RB) cells, the anionic surface-charged poly(lactic-co-glycolic acid) (PLGA) NPs loaded with paclitaxel were conjugated with epithelial cell adhesion molecule (EpCAM) antibody for enhancing site-specific intracellular delivery of paclitaxel against EpCAM overexpressing RB cells. …”
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    Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells
  9. 1229
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    First clinical experience in man with the IMRICOR-MR-EP system:Electrophysiology study guided by real-time MRI
  10. 1230
    “…In order to eliminate potential immunogenicity and investigate the molecular basis of the CAR-mediated T-cell activation, we constructed a novel CAR (CAR57-28ζ) specific for one of the most important TAAs, epithelial cell adhesion molecule (EpCAM), using only human-derived genes. We revealed that in Jurkat T cells, lentivirally expressed CAR57-28ζ can transmit the T-cell-activating signals sufficient to induce IL-2 production upon EpCAM stimulation. …”
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    Molecular Characterization of a Fully Human Chimeric T-Cell Antigen Receptor for Tumor-Associated Antigen EpCAM
  11. 1231
    “…RESULTS: We identified a missense mutation in EPS8L3 (NM_024526.3: exon2: c.22G->A:p.Ala8Thr) within 1p21.1–1q21.3. …”
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    Exome sequencing identified a missense mutation of EPS8L3 in Marie Unna hereditary hypotrichosis
  12. 1232
    “…Recent genome wide screens have found an association between prostaglandin receptor EP4 expression and inflammatory bowel disease; however, EP4 expression has never been studied in MC. …”
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    Lymphocytic Colitis Is Associated with Increased Pro-Inflammatory Cytokine Profile and Up Regulation of Prostaglandin Receptor EP4
  13. 1233
    “…Eps8 is involved in both cell signalling and receptor trafficking. …”
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    Novel Binding Partners and Differentially Regulated Phosphorylation Sites Clarify Eps8 as a Multi-Functional Adaptor
  14. 1234
    “…However, effects of EpCAM overexpression on normal breast epithelial cells have never been studied before. …”
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    EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
  15. 1235
    “…Recent attention has focused on targeting the cyclooxygenase 2 (COX-2) pathway downstream of the COX-2 enzyme by blocking the activities of individual prostaglandin E (EP) receptors. Prostaglandin E receptor 4 (EP4) is widely expressed in primary invasive ductal carcinomas of the breast and antagonizing this receptor with small molecule inhibitors or shRNA directed to EP4 inhibits metastatic potential in both syngeneic and xenograft models. …”
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    Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties
  16. 1236
    “…Putative LCSCs (CD133(+)EpCAM(+)) were present in 6/7 tumor samples, and CD133(+)EpCAM(+) cells were identified in the blood samples of 15 patients at a median level of 40/ml of blood. …”
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    Flow Cytometric Analysis of CD133- and EpCAM-Positive Cells in the Peripheral Blood of Patients with Lung Cancer
  17. 1237
    “…BACKGROUND: Antiretroviral pre-exposure prophylaxis (PrEP) is a novel HIV prevention strategy for which adherence is a known determinant of efficacy. …”
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    HIV Protective Efficacy and Correlates of Tenofovir Blood Concentrations in a Clinical Trial of PrEP for HIV Prevention
  18. 1238
    “…Vernalization, photoperiod and the relatively poorly defined earliness per se (eps) genes regulate flowering in plants. We report here the validation of a major eps quantitative trait locus (QTL) located on wheat 1DL using near isogenic lines (NILs). …”
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    Validation of a 1DL earliness per se (eps) flowering QTL in bread wheat (Triticum aestivum)
  19. 1239
    “…BACKGROUND: Incidence rates in the FEM-PrEP and VOICE trials demonstrate that women from diverse sub-Saharan African communities continue to be at substantial HIV risk. …”
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    The Sexual Risk Context among the FEM-PrEP Study Population in Bondo, Kenya and Pretoria, South Africa
  20. 1240
    “…Prostaglandin E(2) (PGE(2)) is a bioactive lipid mediator that exerts its biological function through interaction with four different subtypes of E-Prostanoid receptor namely EP1, EP2, EP3 and EP4. It has been known that EP2 receptor is differentially over-expressed in the epithelia of inflamed human colonic mucosa. …”
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    Loss of EP2 Receptor Subtype in Colonic Cells Compromise Epithelial Barrier Integrity by Altering Claudin-4
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