“…Overexpression of EpCAM in breast cancer cells enhanced tumor cell growth in vitro and increased invasiveness, whereas small interfering RNA-mediated silencing of EpCAM (si-EpCAM) had the opposite effect. …”
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“…Application of tumor cell surface adhesion molecule EpCAM-dependent antibody capture, and intracellular cytokeratins (CKs)-dependent immunostaining strategies to detect disseminated or circulating tumor cells (DTCs or CTCs), is limited by highly heterogeneous and dynamic expression or absence of EpCAM and/or CKs in CTCs and DTCs, particularly in their capturing and identifying CTCs/DTCs shed from diverse types of solid tumor, thus being biased and restricted to the only both EpCAM and CK positive cancer cells. …”
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“…Cdc42EP3 functions by coordinating the actin and septin networks. …”
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“…PGE2 via prostanoid receptor EP4 stimulates proliferation and motility while inhibiting apoptosis and immune surveillance. …”
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“…Stability, small size, and efficacy of DARPins allowed the generation of MVs simultaneously targeted to tumor marker HER2/neu and cancer stem cell (CSC) marker EpCAM. For optimization, the linker connecting both DARPins was varied in flexibility and length. …”
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“…This divergence in immune circuitry was due to reduced levels of the PGE(2)-EP3 receptor during Salmonella infection when compared to A. phagocytophilum. …”
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“…Molecular markers linked to spotted wilt resistance could overcome this problem and allow selection of resistant lines regardless of environmental conditions. Florida-EP(TM) ‘113’ is a spotted wilt resistant cultivar with a significantly lower infection frequency. …”
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“…Paricalcitol prevented IR-induced cell death and EP4 antagonist cotreatment offset these protective effects. …”
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“…CD44 and EpCAM play crucial roles in intraperitoneal ovarian cancer development. …”
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“…While epithelial cell adhesion molecule (EpCAM) is a marker of normal hepatic stem cells (HSCs), EpCAM+ cells from HCC behave like CSCs. …”
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“…ZFX was commonly enriched in liver EpCAM(+) CSCs. Knockdown of ZFX decreased the proportion of EpCAM(+) CSCs in HCC cells and suppressed their expression of stemness‐related genes, self‐renewal capacity, chemoresistance, metastatic potential, and tumorigenicity. …”
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“…RESULTS: FACS analysis revealed that EpCAM(+) epithelial cells existed in 3 subpopulations based on EpCAM and MHCII expression: EpCAM(med)MHCII(+) cells (Population1:P1), EpCAM(hi)MHCII(−) cells (P2), and EpCAM(low)MHCII(−) cells (P3). proSP-C(+) cells were enriched in P1 cells, and the purity values of the sorted AT2 cells in P1 were 99.0% by immunofluorescence analysis and 98.0% by FACS analysis. …”
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“…Prostaglandin E2 (PGE(2)) is a lipid mediator released from the phospholipid membranes that mediates important physiological functions in the nervous system via activation of four EP receptors (EP1-4). There is growing evidence for the important role of the PGE(2)/EP4 signaling in the nervous system. …”
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“…BACKGROUND: Pre-exposure prophylaxis (PrEP) against HIV infection is available for people at risk of acquiring HIV infection and who are not positive for HIV infection. …”
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“…BACKGROUND: Individuals engaging in higher risk behavior are often more adherent to PrEP but it is unclear if partnership type itself affects PrEP adherence. …”
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“…BACKGROUND: While studies of healthcare professionals have shown increasing awareness, knowledge, positive beliefs, and prescribing practices of emtricitabine/tenofovir pre-exposure prophylaxis (PrEP) for HIV prevention, PrEP is still underutilized in clinical practice. …”
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“…This work is a comparative study of the dosimetry calculated by Plaque Simulator, a treatment planning system for eye plaque brachytherapy, to the dosimetry calculated using Monte Carlo simulation for an Eye Physics model EP917 eye plaque. Monte Carlo (MC) simulation using MCNPX 2.7 was used to calculate the central axis dose in water for an EP917 eye plaque fully loaded with 17 IsoAid Advantage [Formula: see text] seeds. …”
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“…CD44 is used as a CSC marker for breast cancer and EpCAM is used as a CSC marker for HCC. We selected CD44 and EpCAM peptides that bind to HLA-A2 molecules on the basis of their binding affinity, as determined by a peptide-T2 binding assay. …”
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“…Firstly, we found that EPS11 could significantly affect cell proliferation and block cell adhesion in A549 cells. …”
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