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  1. 1
    “…The aim of the study was to evaluate the expression of ephrin receptors EphA1, EphA5, and EphA7 in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. …”
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    Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival
  2. 2
    “…Eph-ephrin system plays a central role in a large variety of human cancers. …”
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    Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation
  3. 3
    por Charmsaz, Sara, Boyd, Andrew W.
    Publicado 2017
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    Eph receptors as oncotargets
  4. 4
    “…Eph receptor tyrosine kinases play critical functions during development, in the formation of tissue and organ borders, and the vascular and neural systems. …”
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    Eph Receptors in Cancer
  5. 5
    “…EphA and B subtypes preferentially bind A- and B-type ephrins, respectively, resulting in receptor complexes that propagate via homotypic Eph–Eph interactions. …”
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    Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors
  6. 6
    “…BACKGROUND: The Eph family of receptor tyrosine kinases plays important roles in neural development. …”
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    EphA5 and EphA6: regulation of neuronal and spine morphology
  7. 7
    “…This study intended to analyze the roles of EphB receptors (EphB2, B3, and B4) in urinary bladder cancer. …”
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    Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion
  8. 8
    “…BACKGROUND: A novel tyrosine kinase receptor EphA2 is expressed at high levels in advanced and metastatic cancers. …”
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    Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors
  9. 9
    “…We previously reported that the axon guidance molecules EphA4 and EphB2 have largely complementary expression patterns in the developing avian VIIIth nerve. …”
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    Differential Roles for EphA and EphB Signaling in Segregation and Patterning of Central Vestibulocochlear Nerve Projections
  10. 10
    “…Another member of the Eph receptor family belonging to the B class, EphB4, has also been found to be upregulated in multiple cancer types. …”
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    Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery
  11. 11
    “…Accordingly, mice lacking EphB1 and EphB2 display a positioning defect of CA3 hippocampal pyramidal neurons, similar to that in Reelin-deficient mice, and this cell migration defect depends on the kinase activity of EphB proteins. …”
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    Reelin induces EphB activation
  12. 12
    por Day, B W, Stringer, B W, Boyd, A W
    Publicado 2014
    “…Here we review the findings to date on the role of Eph family receptor tyrosine kinases and their ephrin ligands in brain cancer. …”
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    Eph receptors as therapeutic targets in glioblastoma
  13. 13
    por Dines, Monica, Lamprecht, Raphael
    Publicado 2015
    “…Recent findings show that Ephs and ephrins are needed for memory formation in different organisms. …”
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    The Role of Ephs and Ephrins in Memory Formation
  14. 14
    “…Here, we analyzed the expression of Eph receptor A3, one of the most up-regulated factors in glioblastoma cells cultured under tumorsphere-forming conditions, together with EphA2 and EphB2 receptors. …”
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    Simultaneous targeting of Eph receptors in glioblastoma
  15. 15
    “…The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. …”
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    Antibody Targeting of Eph Receptors in Cancer
  16. 16
    “…Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly constitute a critical cell signaling network that has multiple functions. …”
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    Targeting EphA2 in cancer
  17. 17
    “…Eph receptors and their ephrin ligands are important guidance molecules during neurological and vascular development. …”
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    Ephs and Ephrins in Adult Endothelial Biology
  18. 18
    “…This review consolidates the available literature of the role of the Eph receptor family, and particularly EphA2, in tumorigenesis, with the aim to develop a better understanding of Eph signalling pathways for potential targeting in novel cancer therapies.…”
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    The Role of the Eph Receptor Family in Tumorigenesis
  19. 19
    “…Although the detailed mechanisms underlying them are varied, the common point is the involvement of Eph receptors and ephrins in their pathogenesis. …”
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    Eph Receptors and Ephrins in Retinal Diseases
  20. 20
    “…The erythropoietin-producing hepatocellular carcinoma (Eph) receptors and their Eph receptor-interacting (ephrin) ligands together constitute a vital cell communication system with diverse roles. …”
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    The Roles of EphB2 in Cancer
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