A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

por Bramsen, Jesper B., Laursen, Maria B., Nielsen, Anne F., Hansen, Thomas B., Bus, Claus, Langkjær, Niels, Babu, B. Ravindra, Højland, Torben, Abramov, Mikhail, Van Aerschot, Arthur, Odadzic, Dalibor, Smicius, Romualdas, Haas, Jens, Andree, Cordula, Barman, Jharna, Wenska, Malgorzata, Srivastava, Puneet, Zhou, Chuanzheng, Honcharenko, Dmytro, Hess, Simone, Müller, Elke, Bobkov, Georgii V., Mikhailov, Sergey N., Fava, Eugenio, Meyer, Thomas F., Chattopadhyaya, Jyoti, Zerial, Marino, Engels, Joachim W., Herdewijn, Piet, Wengel, Jesper, Kjems, Jørgen
Publicado 2009

Comparative Genomics Yields Insights into Niche Adaptation of Plant Vascular Wilt Pathogens

por Klosterman, Steven J., Subbarao, Krishna V., Kang, Seogchan, Veronese, Paola, Gold, Scott E., Thomma, Bart P. H. J., Chen, Zehua, Henrissat, Bernard, Lee, Yong-Hwan, Park, Jongsun, Garcia-Pedrajas, Maria D., Barbara, Dez J., Anchieta, Amy, de Jonge, Ronnie, Santhanam, Parthasarathy, Maruthachalam, Karunakaran, Atallah, Zahi, Amyotte, Stefan G., Paz, Zahi, Inderbitzin, Patrik, Hayes, Ryan J., Heiman, David I., Young, Sarah, Zeng, Qiandong, Engels, Reinhard, Galagan, James, Cuomo, Christina A., Dobinson, Katherine F., Ma, Li-Jun
Publicado 2011

A Diagnostics Platform for the Integrated Mapping, Monitoring, and Surveillance of Neglected Tropical Diseases: Rationale and Target Product Profiles

por Solomon, Anthony W., Engels, Dirk, Bailey, Robin L., Blake, Isobel M., Brooker, Simon, Chen, Jia-Xu, Chen, Jun-Hu, Churcher, Thomas S., Drakeley, Chris J., Edwards, Tansy, Fenwick, Alan, French, Michael, Gabrielli, Albis Francesco, Grassly, Nicholas C., Harding-Esch, Emma M., Holland, Martin J., Koukounari, Artemis, Lammie, Patrick J., Leslie, Jacqueline, Mabey, David C., Rhajaoui, Mohamed, Secor, W. Evan, Stothard, J. Russell, Wei, Hu, Willingham, A. Lee, Zhou, Xiao-Nong, Peeling, Rosanna W.
Publicado 2012

Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery

por Hurley, Amanda, Chevrette, Marc G., Acharya, Deepa D., Lozano, Gabriel L., Garavito, Manuel, Heinritz, Jen, Balderrama, Luis, Beebe, Mara, DenHartog, Martel L., Corinaldi, Kamiyah, Engels, Renee, Gutierrez, Alyssa, Jona, Orli, Putnam, Josephine H. I., Rhodes, Brody, Tsang, Tiffany, Hernandez, Simon, Bascom-Slack, Carol, Blum, Jessamina E., Price, Paul A., Davis, Debra, Klein, Joanna, Pultorak, Joshua, Sullivan, Nora L., Mouncey, Nigel J., Dorrestein, Pieter C., Miller, Sarah, Broderick, Nichole A., Handelsman, Jo
Publicado 2021

To defer or not to defer? A German longitudinal multicentric assessment of clinical practice in urology during the COVID-19 pandemic

por Harke, Nina N., Radtke, Jan P., Hadaschik, Boris A., Bach, Christian, Berger, Frank P., Blana, Andreas, Borgmann, Hendrik, Distler, Florian A., Edeling, Sebastian, Egner, Tobias, Engels, Christina L., Farzat, Mahmoud, Haese, Alexander, Hein, Rainer, Kuczyk, Markus A., Manseck, Andreas, Moritz, Rudolf, Musch, Michael, Peters, Inga, Pokupic, Sasa, Rocco, Bernardo, Schneider, Andreas, Schumann, André, Schwentner, Christian, Sighinolfi, Chiara M., Buse, Stephan, Stolzenburg, Jens-Uwe, Truß, Michael C., Waldner, Michael, Wülfing, Christian, Zimmermanns, Volker, Witt, Jörn H., Wagner, Christian
Publicado 2020

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

por Zekavat, Seyedeh M., Lin, Shu-Hong, Bick, Alexander G., Liu, Aoxing, Paruchuri, Kaavya, Uddin, Md Mesbah, Ye, Yixuan, Yu, Zhaolong, Liu, Xiaoxi, Kamatani, Yoichiro, Pirruccello, James P., Pampana, Akhil, Loh, Po-Ru, Kohli, Puja, McCarroll, Steven A., Neale, Benjamin, Engels, Eric A., Brown, Derek W., Smoller, Jordan W., Green, Robert, Karlson, Elizabeth W., Lebo, Matthew, Ellinor, Patrick T., Weiss, Scott T., Daly, Mark J., Terao, Chikashi, Zhao, Hongyu, Ebert, Benjamin L., Ganna, Andrea, Machiela, Mitchell J., Genovese, Giulio, Natarajan, Pradeep
Publicado 2020

Genomic Analysis of the Basal Lineage Fungus Rhizopus oryzae Reveals a Whole-Genome Duplication

por Ma, Li-Jun, Ibrahim, Ashraf S., Skory, Christopher, Grabherr, Manfred G., Burger, Gertraud, Butler, Margi, Elias, Marek, Idnurm, Alexander, Lang, B. Franz, Sone, Teruo, Abe, Ayumi, Calvo, Sarah E., Corrochano, Luis M., Engels, Reinhard, Fu, Jianmin, Hansberg, Wilhelm, Kim, Jung-Mi, Kodira, Chinnappa D., Koehrsen, Michael J., Liu, Bo, Miranda-Saavedra, Diego, O'Leary, Sinead, Ortiz-Castellanos, Lucila, Poulter, Russell, Rodriguez-Romero, Julio, Ruiz-Herrera, José, Shen, Yao-Qing, Zeng, Qiandong, Galagan, James, Birren, Bruce W., Cuomo, Christina A., Wickes, Brian L.
Publicado 2009

Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy

por Guelen, Lars, Fischmann, Thierry O, Wong, Jerelyn, Mauze, Smita, Guadagnoli, Marco, Bąbała, Nikolina, Wagenaars, Jozef, Juan, Veronica, Rosen, David, Prosise, Winnie, Habraken, Maurice, Lodewijks, Imke, Gu, Danling, Stammen-Vogelzangs, Judith, Yu, Ying, Baker, Jeanne, Lutje Hulsik, David, Driessen-Engels, Lilian, Malashock, Dan, Kreijtz, Joost, Bertens, Astrid, de Vries, Evert, Bovens, Astrid, Bramer, Arne, Zhang, Yiwei, Wnek, Richard, Troth, Sean, Chartash, Elliot, Dobrenkov, Konstantin, Sadekova, Svetlana, van Elsas, Andrea, Cheung, Jason K, Fayadat-Dilman, Laurence, Borst, Jannie, Beebe, Amy M, Van Eenennaam, Hans
Publicado 2022

Long-Term Antibody Response to SARS-CoV-2 in Children

por Dunay, Gabor A., Barroso, Madalena, Woidy, Mathias, Danecka, Marta K., Engels, Geraldine, Hermann, Katharina, Neumann, Friederike S., Paul, Kevin, Beime, Jan, Escherich, Gabriele, Fehse, Kristin, Grinstein, Lev, Haniel, Franziska, Haupt, Luka J., Hecher, Laura, Kehl, Torben, Kemen, Christoph, Kemper, Markus J., Kobbe, Robin, Kohl, Aloisa, Klokow, Thomas, Nörz, Dominik, Olfe, Jakob, Schlenker, Friderike, Schmiesing, Jessica, Schrum, Johanna, Sibbertsen, Freya, Stock, Philippe, Tiede, Stephan, Vettorazzi, Eik, Zazara, Dimitra E., Zapf, Antonia, Lütgehetmann, Marc, Oh, Jun, Mir, Thomas S., Muntau, Ania C., Gersting, Søren W.
Publicado 2022

Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes

por Ferrins, Lori, Buskes, Melissa J., Kapteyn, Madison M., Engels, Hannah N., Enos, Suzanne E., Lu, Chenyang, Klug, Dana M., Singh, Baljinder, Quotadamo, Antonio, Bachovchin, Kelly, Tear, Westley F., Spaulding, Andrew E., Forbes, Katherine C., Bag, Seema, Rivers, Mitch, LeBlanc, Catherine, Burchfield, Erin, Armand, Jeremy R., Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, García-Hernández, Raquel, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, Gómez-Liñán, Claudia, Ruiz-Pérez, Luis Miguel, Gamarro, Francisco, González-Pacanowska, Dolores, Navarro, Miguel, Mensa-Wilmot, Kojo, Pollastri, Michael P., Kyle, Dennis E., Rice, Christopher A.
Publicado 2023

Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes

por Ferrins, Lori, Buskes, Melissa J., Kapteyn, Madison M., Engels, Hannah N., Enos, Suzanne E., Lu, Chenyang, Klug, Dana M., Singh, Baljinder, Quotadamo, Antonio, Bachovchin, Kelly, Tear, Westley F., Spaulding, Andrew E., Forbes, Katherine C., Bag, Seema, Rivers, Mitch, LeBlanc, Catherine, Burchfield, Erin, Armand, Jeremy R., Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, García-Hernández, Raquel, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, Gómez-Liñán, Claudia, Ruiz-Pérez, Luis Miguel, Gamarro, Francisco, González-Pacanowska, Dolores, Navarro, Miguel, Mensa-Wilmot, Kojo, Pollastri, Michael P., Kyle, Dennis E., Rice, Christopher A.
Publicado 2023

The additive value of CA19.9 monitoring in a pancreatic cyst surveillance program

por Levink, Iris J. M., Jaarsma, Sanne C., Koopmann, Brechtje D. M., van Riet, Priscilla A., Overbeek, Kasper A., Meziani, Jihane, Sprij, Marloes L. J. A., Casadei, Riccardo, Ingaldi, Carlo, Polkowski, Marcin, Engels, Megan M. L., van der Waaij, Laurens A., Carrara, Silvia, Pando, Elizabeth, Vornhülz, Marlies, Honkoop, Pieter, Schoon, Erik J., Laukkarinen, Johanna, Bergmann, Jilling F., Rossi, Gemma, van Vilsteren, Frederike G. I., van Berkel, Anne‐Marie, Tabone, Trevor, Schwartz, Matthijs P., Tan, Adriaan C. I. T. L., van Hooft, Jeanin E., Quispel, Rutger, van Soest, Ellert, Czacko, Laszlo, Bruno, Marco J., Cahen, Djuna L.
Publicado 2023

Deficiency of ECHS1 causes mitochondrial encephalopathy with cardiac involvement

por Haack, Tobias B, Jackson, Christopher B, Murayama, Kei, Kremer, Laura S, Schaller, André, Kotzaeridou, Urania, de Vries, Maaike C, Schottmann, Gudrun, Santra, Saikat, Büchner, Boriana, Wieland, Thomas, Graf, Elisabeth, Freisinger, Peter, Eggimann, Sandra, Ohtake, Akira, Okazaki, Yasushi, Kohda, Masakazu, Kishita, Yoshihito, Tokuzawa, Yoshimi, Sauer, Sascha, Memari, Yasin, Kolb-Kokocinski, Anja, Durbin, Richard, Hasselmann, Oswald, Cremer, Kirsten, Albrecht, Beate, Wieczorek, Dagmar, Engels, Hartmut, Hahn, Dagmar, Zink, Alexander M, Alston, Charlotte L, Taylor, Robert W, Rodenburg, Richard J, Trollmann, Regina, Sperl, Wolfgang, Strom, Tim M, Hoffmann, Georg F, Mayr, Johannes A, Meitinger, Thomas, Bolognini, Ramona, Schuelke, Markus, Nuoffer, Jean-Marc, Kölker, Stefan, Prokisch, Holger, Klopstock, Thomas
Publicado 2015

Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross

por Sá, Juliana M., Kaslow, Sarah R., Moraes Barros, Roberto R., Brazeau, Nicholas F., Parobek, Christian M., Tao, Dingyin, Salzman, Rebecca E., Gibson, Tyler J., Velmurugan, Soundarapandian, Krause, Michael A., Melendez-Muniz, Viviana, Kite, Whitney A., Han, Paul K., Eastman, Richard T., Kim, Adam, Kessler, Evan G., Abebe, Yonas, James, Eric R., Chakravarty, Sumana, Orr-Gonzalez, Sachy, Lambert, Lynn E., Engels, Theresa, Thomas, Marvin L., Fasinu, Pius S., Serre, David, Gwadz, Robert W., Walker, Larry, DeConti, Derrick K., Mu, Jianbing, Bailey, Jeffrey A., Sim, B. Kim Lee, Hoffman, Stephen L., Fay, Michael P., Dinglasan, Rhoel R., Juliano, Jonathan J., Wellems, Thomas E.
Publicado 2019

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

por Geuijen, Cecile, Tacken, Paul, Wang, Liang-Chuan, Klooster, Rinse, van Loo, Pieter Fokko, Zhou, Jing, Mondal, Arpita, Liu, Yao-bin, Kramer, Arjen, Condamine, Thomas, Volgina, Alla, Hendriks, Linda J. A., van der Maaden, Hans, Rovers, Eric, Engels, Steef, Fransen, Floris, den Blanken-Smit, Renate, Zondag-van der Zande, Vanessa, Basmeleh, Abdul, Bartelink, Willem, Kulkarni, Ashwini, Marissen, Wilfred, Huang, Cheng-Yen, Hall, Leslie, Harvey, Shane, Kim, Soyeon, Martinez, Marina, O’Brien, Shaun, Moon, Edmund, Albelda, Steven, Kanellopoulou, Chrysi, Stewart, Shaun, Nastri, Horacio, Bakker, Alexander B. H., Scherle, Peggy, Logtenberg, Ton, Hollis, Gregory, de Kruif, John, Huber, Reid, Mayes, Patrick A., Throsby, Mark
Publicado 2021

Scalable psychological interventions for Syrian refugees in Europe and the Middle East: STRENGTHS study protocol for a prospective individual participant data meta-analysis

por de Graaff, Anne M, Cuijpers, Pim, Acarturk, Ceren, Akhtar, Aemal, Alkneme, Mhd Salem, Aoun, May, Awwad, Manar, Bawaneh, Ahmad Y, Brown, Felicity L, Bryant, Richard, Burchert, Sebastian, Carswell, Kenneth, Drogendijk, Annelieke, Engels, Michelle, Fuhr, Daniela C, Hansen, Pernille, van 't Hof, Edith, Giardinelli, Luana, Hemmo, Mahmoud, Hessling, Jonas M, Ilkkursun, Zeynep, Jordans, Mark J D, Kiselev, Nikolai, Knaevelsrud, Christine, Kurt, Gülsah, Martinmäki, Saara, McDaid, David, Morina, Naser, Naser, Hadeel, Park, A-La, Pfaltz, Monique C, Roberts, Bayard, Schick, Matthis, Schnyder, Ulrich, Spaaij, Julia, Steen, Frederik, Taha, Karine, Uygun, Ersin, Ventevogel, Peter, Whitney, Claire, Witteveen, Anke B, Sijbrandij, Marit
Publicado 2022

Early Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective: Results of the CUREiHUS Study

por Bouwmeester, Romy N., Duineveld, Caroline, Wijnsma, Kioa L., Bemelman, Frederike J., van der Heijden, Joost W., van Wijk, Joanna A.E., Bouts, Antonia H.M., van de Wetering, Jacqueline, Dorresteijn, Eiske, Berger, Stefan P., Gracchi, Valentina, van Zuilen, Arjan D., Keijzer-Veen, Mandy G., de Vries, Aiko P.J., van Rooij, Roos W.G., Engels, Flore A.P.T., Altena, Wim, de Wildt, Renée, van Kempen, Evy, Adang, Eddy M., ter Avest, Mendy, ter Heine, Rob, Volokhina, Elena B., van den Heuvel, Lambertus P.W.J., Wetzels, Jack F.M., van de Kar, Nicole C.A.J.
Publicado 2022

BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells

por van Helden, Mary J, Zwarthoff, Seline A, Arends, Roel J, Reinieren-Beeren, Inge M J, Paradé, Marc C B C, Driessen-Engels, Lilian, de Laat-Arts, Karin, Damming, Désirée, Santegoeds-Lenssen, Ellen W H, van Kuppeveld, Daphne W J, Lodewijks, Imke, Olsman, Hugo, Matlung, Hanke L, Franke, Katka, Mattaar-Hepp, Ellen, Stokman, Marloes E M, de Wit, Benny, Glaudemans, Dirk H R F, van Wijk, Daniëlle E J W, Joosten-Stoffels, Lonnie, Schouten, Jan, Boersema, Paul J, van der Vleuten, Monique, Sanderink, Jorien W H, Kappers, Wendela A, van den Dobbelsteen, Diels, Timmers, Marco, Ubink, Ruud, Rouwendal, Gerard J A, Verheijden, Gijs, van der Lee, Miranda M C, Dokter, Wim H A, van den Berg, Timo K
Publicado 2023

New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated actin dynamics

por Begemann, Anaïs, Sticht, Heinrich, Begtrup, Amber, Vitobello, Antonio, Faivre, Laurence, Banka, Siddharth, Alhaddad, Bader, Asadollahi, Reza, Becker, Jessica, Bierhals, Tatjana, Brown, Kathleen E., Bruel, Ange-Line, Brunet, Theresa, Carneiro, Maryline, Cremer, Kirsten, Day, Robert, Denommé-Pichon, Anne-Sophie, Dyment, Dave A., Engels, Hartmut, Fisher, Rachel, Goh, Elaine S., Hajianpour, M. J., Haertel, Lucia Ribeiro Machado, Hauer, Nadine, Hempel, Maja, Herget, Theresia, Johannsen, Jessika, Kraus, Cornelia, Le Guyader, Gwenaël, Lesca, Gaetan, Mau-Them, Frédéric Tran, McDermott, John Henry, McWalter, Kirsty, Meyer, Pierre, Õunap, Katrin, Popp, Bernt, Reimand, Tiia, Riedhammer, Korbinian M., Russo, Martina, Sadleir, Lynette G., Saenz, Margarita, Schiff, Manuel, Schuler, Elisabeth, Syrbe, Steffen, Van der Ven, Amelie Theresa, Verloes, Alain, Willems, Marjolaine, Zweier, Christiane, Steindl, Katharina, Zweier, Markus, Rauch, Anita
Publicado 2020

Lessons learned after one year of COVID-19 from a urologist and radiotherapist view: A German survey on prostate cancer diagnosis and treatment

por Harke, Nina N., Wagner, Christian, Hermann, Robert M., Hadaschik, Boris A., Radtke, Jan Philipp, Altay-Langguth, Alev, Aufderklamm, Stefan, Bach, Christian, Becker-Schiebe, Martina, Blana, Andreas, Bruns, Frank, Buse, Stephan, Combs, Stephanie E., Engels, Christina L., Ezzibdeh, Emad, Fiedler, Marcel, Fischer, Laura-Anna, Farzat, Mahmoud, Frismann, Alexander, Heck, Matthias M., Henkenberens, Christoph, Roesch, Marie C., Käding, Christoph, Klautke, Gunther, Krausewitz, Philipp, Kuczyk, Markus A., Leitsmann, Conrad, Lettmaier, Sebastian, Mahjoub, Samy, Manseck, Andreas, Medenwald, Daniel, Meyer, Andreas, Micke, Oliver, Moritz, Rudolf, Ott, Marcel, Peters, Inga, Pokupic, Sasa, Porres, Daniel, Preisser, Felix, Reichel, Kathrin, Schneider, Andreas, Schwentner, Christian, Scobioala, Sergiu, Truss, Michael, Wegener, Daniel, Wezel, Felix, Willborn, Kay, Witt, Jörn H., Wittig, Andrea, Wittlinger, Michael, Wolff, Hendrik A., Zimmermanns, Volker, Christiansen, Hans
Publicado 2022