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  1. 421
    “…Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. …”
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    EP2 inhibition restores myeloid metabolism and reverses cognitive decline
  2. 422
    “…[Formula: see text] -ep employs the monodomain equation to model the heart’s electrical activity. …”
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    lifex-ep: a robust and efficient software for cardiac electrophysiology simulations
  3. 423
    “…Preexposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) prevention is approved for use in adolescents, though uptake remains low. …”
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    Black Adolescent Females’ Perceptions of PrEP for HIV Risk Reduction
  4. 424
    “…To explore the role of Eps15 and the function of AP-2/Eps15 association in endocytosis, the Eps15 binding domain for AP-2 was precisely delineated. …”
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    AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis
  5. 425
    “…We mapped Tyr 850 as the major in vivo tyrosine phosphorylation site of Eps15. A phosphorylation-negative mutant of Eps15 acted as a dominant negative on the internalization of the EGFR, but not of the TfR. …”
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    Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis
  6. 426
    “…It is proposed that Eps15 and its family members Eps15R and Eps15b are involved in the regulation of membrane morphology, which is required for intracellular vesicle formation and trafficking.…”
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    Eps15: a multifunctional adaptor protein regulating intracellular trafficking
  7. 427
    “…For the case of contact-inhibited cells, although cleavage of EpCAM occurred, nuclear translocation of EpICD was reduced, as were EpCAM effects. …”
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    Initial activation of EpCAM cleavage via cell-to-cell contact
  8. 428
    “…We have previously shown that a Glossina-specific, immunoresponsive molecule, tsetse EP protein, is up regulated by the fly in response to gram-negative microbial challenge. …”
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    Tsetse EP Protein Protects the Fly Midgut from Trypanosome Establishment
  9. 429
    “…BACKGROUND: Recently, EpCAM has attracted major interest as a target for antibody- and vaccine-based cancer immunotherapies. …”
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    Effects of EpCAM overexpression on human breast cancer cell lines
  10. 430
    “…EpCAM expression frequently correlates with more aggressive tumour behaviour and new EpCAM-specific therapeutic agents have recently been approved for clinical use in patients with cancer. …”
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    EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis
  11. 431
    “…The involvement of the EP4 receptor was substantiated by a selective EP4 antagonist, which reversed the inhibitory effects of PGE(2) and the EP4 agonist. …”
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    EP4 receptor stimulation down-regulates human eosinophil function
  12. 432
    “…The large difference in observed EPS production may be accounted for by consistently higher photochemical efficiency of photosystem II in the large (0.5) vs. small (∼0.35) strains. …”
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    Constitutive Extracellular Polysaccharide (EPS) Production by Specific Isolates of Crocosphaera watsonii
  13. 433
    “…As reviewed here, the EP1, EP2, and EP4 receptors, but not the EP3 receptor, contribute to NMSC development, albeit through different signaling pathways and with somewhat different outcomes. …”
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    The role of the EP receptors for prostaglandin E(2) in skin and skin cancer
  14. 434
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    EP4-mediated prostanoid signalling promotes oral cancer progression
  15. 435
    “…BACKGROUND: Variovorax paradoxus is an aerobic soil bacterium associated with important biodegradative processes in nature. We use V. paradoxus EPS to study multicellular behaviors on surfaces. …”
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    Genes That Influence Swarming Motility and Biofilm Formation in Variovorax paradoxus EPS
  16. 436
    “…The large variety of biological functions governed by prostaglandin (PG) E(2) is mediated by signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse strains with genetic ablation of each EP receptor subtype and the development of selective EP agonists and antagonists have tremendously advanced our understanding of PGE(2) as a physiologically and clinically relevant mediator. …”
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    E-type prostanoid receptor 4 (EP4) in disease and therapy
  17. 437
    “…Although hemin-mediated neurotoxicity has been linked to the production of free radicals and glutamate excitotoxicity, the role of the prostaglandin E(2) (PGE(2))-EP1 receptor remains unclear. Activation of the EP1 receptor in neurons results in increased intracellular calcium levels; therefore, we hypothesize that the blockade of the EP1 receptor reduces hemin neurotoxicity. …”
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    Contribution of PGE(2) EP1 receptor in hemin-induced neurotoxicity
  18. 438
    “…We used EPS8 RNA interference to determine the effect of decreased EPS8 expression on LCL and A549 lung cancer cell sensitivity to cisplatin. …”
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    EPS8 Inhibition Increases Cisplatin Sensitivity in Lung Cancer Cells
  19. 439
    “…We generated EP4(Flox/Flox) and EP4(+/−) mice, cultured primary WT, EP4(Flox/Flox) and EP4(+/−) GMCs, AD-EP4 transfected WT GMCs (EP4 overexpression) and AD-Cre transfected EP4(Flox/Flox) GMCs (EP4 deleted). …”
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    A Maladaptive Role for EP4 Receptors in Mouse Mesangial Cells
  20. 440
    por Do, Jin Hwan
    Publicado 2014
    “…In this study, pathways that were significantly perturbed in MPP(+)-treated human neuroblastoma SH-EP cells were identified from genome-wide gene expression data for five time points (1.5, 3, 9, 12, and 24 h) after treatment. …”
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    Neurotoxin-Induced Pathway Perturbation in Human Neuroblastoma SH-EP Cells
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