“…To distinguish these roles, we generated a knockin mouse carrying a mutated Rap1, which was incapable of binding telomeres and did not result in eroded telomeres or a DDR. Primary Rap1 knockin embryonic fibroblasts showed decreased RAP1 expression and re-localization away from telomeres, with an increased cytosolic distribution akin to that observed in human fibroblasts undergoing telomere erosion. …”
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“…Proliferated hPSCs with XIST reactivation show XCI from an eroded X chromosome, suggesting that hPSCs with normal dosage compensation might lead to a growth advantage. …”
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“…We investigated a nature-based solution (NbS) via incorporating biocrust into alfalfa-maize intercropping system to test carbon sequestration in seriously eroded agricultural soils. Field investigation showed that the NbS (moss-dominated biocrust + intercropping) massively lowered surface soil erosion by 94.5% and soil carbon (C) and nitrogen (N) loss by 94.7 and 96.8% respectively, while promoting rainwater interception by 82.2% relative to bare land (CK). …”
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“…Both groups of compounds induce hepatic aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-o-deethylase (EROD) in rats and cause wasting and thymic atrophy in rats and guinea pigs. …”
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“…Intraoperatively, the TMJ was completely eroded by the mass. Final pathology was consistent with tophaceous pseudogout. …”
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“…As the activation temperature or time increased, air eroded the defective surface of charcoal layer-by-layer, with the oxygen atoms being introduced by chemisorption and oxidation reactions and removed by dehydration and decomposition reactions. …”
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“…Based on these findings, a concern about the risk of eroding trust toward Internet sources about healthcare information is raised. …”
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“…A moderate amount of CDMC promoted biogas evolution, while excess CDMC eroded both H(2) and CH(4) productivity. The CDMC (600 mg L(−1)) group achieved the highest biogas yields of 176 mL H(2) per g glucose and 358 mL CH(4) per g glucose, which were higher than those (102 mL H(2) per g glucose and 288 mL CH(4) per g glucose) found in the control group without CDMC. …”
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“…The southern exposition slope’s soil was slightly eroded Eutric Retisol (loamic) (RT-eu.lo), and the steepness of the slope was 9–11°. …”
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“…By cross‐linking short poly(ethylene glycol) (PEG) chains with erodible linkers within a shape‐defining template, a deformable and biodegradable polymeric skeleton is realized and loaded with a variety of therapeutic and imaging agents, including docetaxel‐nanoparticles. …”
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“…The study finds that the proposed models generate positive returns (net of trading costs), in spite of fact that intraday trading frequently erodes profits. The M_Omega and R_Omega models produce a higher return than that of the S&P 500 index or NASDAQ 100 index, considering the intraday trading cost. …”
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“…Our analytical results suggested that the daily higher regimen specifically increased the number of eroded pores creating spaces between existing canals, thus stimulating cortical bone remodeling.…”
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“…Erosion of human primary enamel tended to be higher than that of permanent teeth, whereas dentin showed the opposite behaviour. SEM showed that eroded equine dentin appeared more irregular than human or bovine dentin. …”
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“…Rock pools are eroded depressions in bedrock providing temporary aquatic habitats with varying morphometric and chemical conditions. …”
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“…On the flank of the Andes, forests that have never burned are being eroded by fire spreading downslope from grasslands. …”
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“…The principal threatening factors reported were deforestation (90%), agricultural expansion (85%) and fire (53%). Documenting the eroding plants and associated indigenous knowledge can be used as a basis for developing management plans for conservation and sustainable use of medicinal plants in the area.…”
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“…However, the trust placed on them is eroding. Evidence for this includes accusations of a decline in their humanitarianism, and the increasing number of conflicts with host states. …”
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“…Inbreeding thus plays a pivotal role in this process and is expected to limit the probability of genetically eroded populations to successfully adapt to stressful environmental conditions. …”
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“…The recent claim that the ‘phosphorus paradigm’ for recovering lakes from eutrophication has been ‘eroded’ has no basis. Instead, the case for phosphorus control has been strengthened by numerous case histories and large-scale experiments spanning several decades.…”
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“…In addition, it can be shown that even a small reduction in linkage disequilibrium between causal variants and observed SNPs rapidly erodes estimates of epistatic variance, leading to an inflation in the perceived importance of additive effects. …”
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