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  1. 2121
    “…Approved immunotherapeutic approaches are currently mainly based on immune checkpoint inhibitors, antibody-derived targeted therapies, or cell-based immunotherapies. In essence, these therapies induce or enhance the infiltration and function of tumor-reactive T cells within the tumors, ideally resulting in complete tumor eradication. …”
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    Promise and challenges of clinical non-invasive T-cell tracking in the era of cancer immunotherapy
  2. 2122
    “…It is an action linking UE that emphasises the problem of cohesion in the interregional context. The essence of territorial cohesion is the necessity to eliminate inequalities between the living conditions of the population. …”
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    Assessment of the Living Conditions in Polish and German Transborder Regions in the Context of Strengthening Territorial Cohesion in the European Union: Competitiveness or Complementation?
  3. 2123
    por Sanyal, Gautam
    Publicado 2022
    “…Potency is a critical quality attribute that is also monitored as a stability indicator of a vaccine product. In essence, a potency measurement is a test of the functional integrity of the antigen and is intended to ensure that the antigen retains immunocompetence, i.e., the ability to stimulate the desired immune response, in its final formulation. …”
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    Development of functionally relevant potency assays for monovalent and multivalent vaccines delivered by evolving technologies
  4. 2124
    “…Among the providers, 53.3% reported that end-of-life ward discussions took place only when there was a life-threatening situation and 11.1%–16.5% never engaged in end-of-life communication regarding EOL patient’s preferences, appointing an attorney for the patient, disease trajectory or the essence of palliative care, with patients or their representatives. …”
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    Practice of end-of-life care for patients with advanced dementia by hospital physicians and nurses: Comparison between medical and surgical wards
  5. 2125
    “…The considered system contains four identical channels, each with a single fundamental transverse mode. The essence of this type of nonlinear coupler is to examine the effect of two or more competing nonlinearities on the generated nonclassical features in this class of devices. …”
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    Quantum features of nonlinear coupler with competing nonlinearity
  6. 2126
    “…Succeeding the first perturbation cycle, visual afferents were downregulated to reduce the destabilizing influence of the sensory conflicts. In essence, only the transient beginning of sinusoidal oscillation alters balance compared to quiet standing. …”
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    Sinusoidal Optic Flow Perturbations Reduce Transient but Not Continuous Postural Stability: A Virtual Reality-Based Study
  7. 2127
    por Hong, Na
    Publicado 2022
    “…The exact balance between the connotation essence of traditional culture and the emotional resonance in modern life has not yet been found, and the visual language belonging to cultural aesthetics under the combination of traditional and modern aesthetics needs to be explored for a long time. …”
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    Digital-Media-Based Interaction and Dissemination of Traditional Culture Integrating Using Social Media Data Analytics
  8. 2128
    “…The proposed HEI-SGFD scheme nearly doubles the wave-equation simulation speed compared to the implicit SGFD schemes. In essence, the proposed HEI-SGFD scheme is equivalent to the second-order FD scheme with ordinary grid format. …”
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    A hybrid explicit implicit staggered grid finite-difference scheme for the first-order acoustic wave equation modeling
  9. 2129
    “…So, implementing an alternative approach for targeting TKIs insensitive cells would be of the essence. Dihydroorotate dehydrogenase (DHODH) is an enzyme in the de novo pyrimidine biosynthesis pathway that is located in the inner membrane of mitochondria. …”
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    Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
  10. 2130
    “…Our effort to map elementary behaviours to specific brain loci and to further manipulate neural activity while observing the alterations in behaviour is in essence the goal for neuroscientists. Recent advancements in the area of experimental brain imaging in the form of longer wavelength near infrared (NIR) pulsed lasers with the development of highly efficient optogenetic actuators and reporters of neural activity, has endowed us with unprecedented resolution in spatiotemporal precision both in imaging neural activity as well as manipulating it with multiphoton microscopy. …”
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    Advantages, Pitfalls, and Developments of All Optical Interrogation Strategies of Microcircuits in vivo
  11. 2131
    “…We also demonstrate that a peptide’s ability to concurrently induce excess leaflet area (tension) and elastic softening—a property we call the “characteristic area of sensing” (CHAOS)—and lipid packing sensing behavior are in fact two sides of the same coin. In essence, defect sensing displays a peptide’s propensity to generate tension. …”
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    Efficient Quantification of Lipid Packing Defect Sensing by Amphipathic Peptides: Comparing Martini 2 and 3 with CHARMM36
  12. 2132
    “…Thus, our study uncovered a contributor with good prognostic value to CRC pathogenesis and also elucidated the essence of DNA-binding TFs in orchestrating the epigenetic programming of gene regulation.…”
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    Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci
  13. 2133
    por Friel, Sharon
    Publicado 2020
    “…Environmental harm, including climate change and biodiversity loss, occurs along the supply chains associated with trans-national corporations’ (TNCs’) practices and products. In essence, the corporatization of the global food system has created the conditions that cultivate excess consumption, manufacture disease epidemics and harm the environment. …”
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    Redressing the Corporate Cultivation of Consumption: Releasing the Weapons of the Structurally Weak
  14. 2134
    “…By analyzing the molecular structures, MAFcTAZ has a higher iron content and nitrogen content, which are the essence of its excellent catalytic performance. From the perspective of interaction energy, the strong catalytic effect of MAFcTAZ is attributed to its large interaction energy with FOX-12 by energy decomposition analysis.…”
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    Catalytic Effect of Ferrocenyl Energetic Catalysts for N-Guanylurea Dinitramide (GUDN or FOX-12) Decomposition
  15. 2135
    “…The transcribed interviews were analyzed in four phases which is an iterative process as proposed by Dahlberg and Dahlberg. FINDINGS: The essence of the phenomenon was experiencing less panic and finding peace, which emerged from the following four patterns. (1) The FMs’ post-AF experience, (2) Enhanced understanding and knowledge of AF, (3) Personal interaction with a nurse specialist and (4) AF becomes manageable. …”
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    How Family Members Experienced a Family-Focused Atrial Fibrillation Intervention in an Outpatient Setting—A Qualitative Study
  16. 2136
    “…Data were analysed with a phenomenological reflective lifeworld approach. FINDINGS: The essence of the women’s experiences of being pregnant during the COVID-19 pandemic was best described as being in the shadow of the unknown, where the COVID-19 pandemic could at times totally overshadow the experience of being pregnant, while at other times, rays of sunlight pierced through the clouds. …”
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    Being in the shadow of the unknown — Swedish women’s lived experiences of pregnancy during the COVID-19 pandemic, a phenomenological study
  17. 2137
    “…ETHICS AND DISSEMINATION: The essence of this study is to summarise and analyse the original data without the approval of the ethics committee. …”
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    Comparative efficacy of eight therapeutic methods in the treatment of left main coronary artery disease: a Bayesian network meta-analysis protocol
  18. 2138
    “…A concerted strategic approach to building up complementary sustainable infrastructures among the global network of airports based in various international tourist destination cities to enable a measurable reduction in carbon emission is necessary to achieve a transformational adaptation of a business sector that is of essence to the recovery of the global economy while attempting to tackle climate change in a post-COVID-19 era.…”
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    Global tourism, climate change and energy sustainability: assessing carbon reduction mitigating measures from the aviation industry
  19. 2139
    “…This simple, but not simplistic approach allows ethical issues to be communicative and operational. The essence of the paper is captured in a set of eleven microbiome ethics recommendations, e.g., proposing gut microbiome status as common global heritage, similar to the internationally agreed status of major food crops.…”
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    Microbiome ethics, guiding principles for microbiome research, use and knowledge management
  20. 2140
    “…Such overwhelming success in sales was partly because in essence, these are quite traditional and familiar aircrafts that featured improvements in some critical systems, notably in the use of newer engines. …”
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    Emissions of future conventional aircrafts adopting evolutionary technologies
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