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  1. 116341
    “…METHODS: Macrophages were exposed to IAPP in the presence or absence of plasma-purified human C4BP, and inflammasome activation was assessed by IL-1β secretion as detected by ELISA and reporter cell lines. …”
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    The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation
  2. 116342
    “…Results: Between May 2011 and January 2013, 156 children initiated ART at a median age of 13.9 months (interquartile range: 7.8–18.4); 63% were from Abidjan; 53% were girls; 37% were not exposed to any PMTCT intervention or maternal ART; mother was the main caregiver in 81%; 61% were classified World Health Organization Stage 3 to 4. …”
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    Virological response and resistances over 12 months among HIV-infected children less than two years receiving first-line lopinavir/ritonavir-based antiretroviral therapy in Cote d’Ivoire and Burkina Faso: the MONOD ANRS 12206 cohort
  3. 116343
    “…Depending on definitions, 25-50 % of patients aged 75 years or older are exposed to at least five drugs. Evidence is increasing that polypharmacy, even when guidelines advise the prescribing of each drug individually, can potentially cause more harm than benefit to older patients, due to factors such as drug-drug and drug-disease interactions. …”
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    Polypharmacy in chronic diseases–Reduction of Inappropriate Medication and Adverse drug events in older populations by electronic Decision Support (PRIMA-eDS): study protocol for a randomized controlled trial
  4. 116344
    “…The noted prevalence of enteric protozoa among US service members in this study is higher than in prior reports, approaching prevalence expected in the general host nation population, suggesting that US service members operating at Al-Asad Air Base in early OIF were exposed to greater degrees of fecally contaminated food and water, and poor hygienic and sanitation practices. …”
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    A cross-sectional analysis of clinical presentations of and risk factors for enteric protozoan Infections in an Active Duty Population during Operation Iraqi Freedom
  5. 116345
    “…LIMITATIONS: Control data for age-matched subjects not exposed to lithium were lacking. CONCLUSIONS: Long-term lithium treatment was associated with gradual decline of renal functioning (eGFR) by about 30% more than that was associated with aging alone. …”
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    Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters
  6. 116346
    “…In an independent group design, 18 healthy men were exposed to 40 min of (1) passive whole-body HPC (FiO(2) = 0.143; no ischemia. …”
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    Hypoxic Air Inhalation and Ischemia Interventions Both Elicit Preconditioning Which Attenuate Subsequent Cellular Stress In vivo Following Blood Flow Occlusion and Reperfusion
  7. 116347
    “…To examine LOXL2-induced effect in vivo, we implanted Matrigel-imbedded human chondrocytes into nude mice and exposed them to exogenous LOXL2 for 6 weeks. Finally, LOXL2-induced effects on collagen type 2 α1 (COL2A1) and phospho-SMAD2/3 were evaluated by immunofluorescence analysis. …”
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    Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis
  8. 116348
    “…Protein expression analysis revealed an activation of the Hh- and PI3K/AKT/mTOR pathways in tumors exposed to (177)Lu-octreotate monotherapy and combination therapy. …”
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    Hedgehog inhibitor sonidegib potentiates (177)Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice
  9. 116349
    “…Na(+) ions were mostly compartmentalized in vacuoles. Roots exposed to NaCl showed increased levels of extracellular ATP (eATP), cytosolic Ca(2+), H(2)O(2), and NO. …”
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    Salt-Sensitive Signaling Networks in the Mediation of K(+)/Na(+) Homeostasis Gene Expression in Glycyrrhiza uralensis Roots
  10. 116350
    “…The order that participants were exposed to each condition was randomized (via random number generator). …”
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    Acute effects of reducing sitting time in adolescents: a randomized cross-over study
  11. 116351
    “…METHODS: Cow and buffalo milk was exposed to two different heat treatments i.e. 65 °C for 30 min and boiling for 1 min. …”
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    Antioxidant capacity and fatty acids characterization of heat treated cow and buffalo milk
  12. 116352
    “…In vitro, splenocytes taken from 100 days old hSOD1(G93A) mice showed significantly increased proliferation when exposed to LPS (p = 0.0002), a phenomenon that was reduced by TAK-242 (p = 0.0179). …”
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    Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model
  13. 116353
    “…BACKGROUND: The CD4-induced (CD4i) epitopes in gp120 includes the co-receptor binding site, which are formed and exposed after interaction with CD4. Monoclonal antibodies (mAbs) to the CD4i epitopes exhibit limited neutralizing activity because of restricted access to their epitopes. …”
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    Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes
  14. 116354
    “…The age and calendar-time adjusted IRR comparing exposed time to unexposed time was greater for concomitant IIV and PCV13 (IRR 2.80, 95% CI 1.63, 4.83), as compared with that for PCV13 without concomitant IIV (IRR 1.54, 95% CI 1.04, 2.28). …”
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    The Risk of Febrile Seizures Following Influenza and 13-Valent Pneumococcal Conjugate Vaccines
  15. 116355
    “…Compared with ctrls, CSE patients more often had prior fluoroquinolone use (OR 7.4), while KPC-CRE patients were more likely exposed to carbapenems or aminoglycosides (ORs 9.1 and 7.1). …”
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    A Multicenter Case-Case–control Study of Factors Associated with Klebsiella pneumoniae Carbapenemase (KPC)-Producing Enterobacteriaceae (KPC-CRE) Infections in Children
  16. 116356
    “…CONCLUSION: CNS IMIs occur in ill patients with active HC who are often pre-exposed to antifungals. Immune response in pathology, steroid tapering and possibly surgical drainage are associated with improved outcome. …”
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    Invasive Mold Infections (IMIs) of the Central Nervous System (CNS) in Patients with Hematologic Cancer (HC) (2000–2016): Uncommon but Deadly
  17. 116357
    “…Reported dietary supplement use in deployed troops is limited and is of concern in settings where troops are exposed to high ambient temperatures, increased physical demands, and dehydration. …”
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    Self-reported dietary supplement use in deployed United States service members pre-deployment vs. during deployment, Afghanistan, 2013–2014
  18. 116358
    “…When NRK-52E cells, injured by exposing to oxalate crystals for 24 h, were treated with NRE, it appreciably prevented the cell injury in a dose-dependent manner. …”
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    Antiurolithiatic Potential of Neeri against Calcium-Oxalate Stones by Crystallization Inhibition, Free Radicals Scavenging, and NRK-52E Cell Protection from Oxalate Injury
  19. 116359
    “…Methods and Results: HCMs were exposed to hypoxia (18 h) and reoxygenation (2 h) (H/R), with or without TXL pretreatment. …”
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    Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1
  20. 116360
    “…METHODS: In two CHMI trials, CHMI-a and CHMI-b, 15 and 24 healthy malaria-naïve volunteers, respectively, were exposed to bites of infected mosquitoes, using the P. falciparum research strain NF54 and the novel clones NF135.C10 and NF166.C8. …”
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    Changes in total and differential leukocyte counts during the clinically silent liver phase in a controlled human malaria infection in malaria-naïve Dutch volunteers
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