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116721por Huang, Yuji, Liang, Boxuan, Li, Zhiming, Zhong, Yizhou, Wang, Bo, Zhang, Bingli, Du, Jiaxin, Ye, Rongyi, Xian, Hongyi, Min, Weicui, Yan, Xiliang, Deng, Yanhong, Feng, Yu, Bai, Ruobing, Fan, Bingchi, Yang, Xingfen, Huang, Zhenlie“…We validated melatonin's intervention (intraperitoneal, 10 mg/kg/d) in C57BL/6 J mice exposed to 250 mg/kg/d of PS-NPs for 28 days. RESULTS: In our in vitro experiments, we observed PS-NP accumulation in cells, including mitochondria, leading to cell toxicity and reduced viability. …”
Publicado 2023
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116722por Katuwal, Nar Bahadur, Kang, Min Sil, Ghosh, Mithun, Hong, Sa Deok, Jeong, Yeong Gyu, Park, Seong Min, Kim, Seul-Gi, Sohn, Joohyuk, Kim, Tae Hoen, Moon, Yong Wha“…METHODS: Palbociclib-resistant cells were generated by exposing human HR+ breast cancer cell lines to palbociclib for 7–9 months. …”
Publicado 2023
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116723por Tolstova, Tatiana, Dotsenko, Ekaterina, Kozhin, Peter, Novikova, Svetlana, Zgoda, Victor, Rusanov, Alexander, Luzgina, Nataliya“…METHODS: Flow cytometry and histochemical staining were used to analyze MSCs for immunophenotype and differentiation potential. MSCs were exposed to poly(I:C) at 1 and 10 μg/mL for 1, 3, and 24 h, followed by determination of the expression of IDO1, WARS1, PD-L1, TSG-6, and PTGES2 and PGE2 secretion. …”
Publicado 2023
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116724por Tian, Xuechen, Teo, Wee Fei Aaron, Wee, Wei Yee, Yang, Yixin, Ahmed, Halah, Jakubovics, Nicholas S., Choo, Siew Woh, Tan, Geok Yuan Annie“…Pathogenicity analysis highlighted the potential human pathogenicity risk associated with both strains, with several virulence-associated factors identified. CRISPR-Cas analysis exposed the presence of CRISPR and Cas genes in both strains, indicating these strains might evolve a robust defense mechanism against them. …”
Publicado 2023
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116725por Watson, Quentin D., Carias, Lenore L., Malachin, Alyssa, Redinger, Karli R., Bosch, Jürgen, Bardelli, Martino, Baldor, Lea, Feufack-Donfack, Lionel Brice, Popovici, Jean, Moon, Robert W., Draper, Simon J., Zimmerman, Peter A., King, Christopher L.“…METHODS: Here, the functional activity of humAbs derived from naturally exposed and vaccinated individuals are compared for the first time using easily cultured Plasmodium knowlesi (P. knowlesi) that had been genetically modified to replace its endogenous PkDBP orthologue with PvDBP to create a transgenic parasite, PkPvDBPOR. …”
Publicado 2023
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116726por Comella, P, Casaretti, R, Crucitta, E, De Vita, F, Palmeri, S, Avallone, A, Orditura, M, De Lucia, L, Del Prete, S, Catalano, G, Lorusso, V, Comella, G“…From April 1999 to December 2000, 50 patients were enrolled: 26 were males and 24 females, their median age was 63 (range, 43–79) years; ECOG performance status was 0 in 26 patients, ⩾1 in 24 patients; 26 patients had received previous adjuvant chemotherapy, 40 patients had been exposed to one or two lines of palliative chemotherapy (including irinotecan in 31 cases); 18 patients were considered chemo-refractory. …”
Publicado 2002
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116727por Pedersen, Marie, Schoket, Bernadette, Godschalk, Roger W., Wright, John, von Stedingk, Hans, Törnqvist, Margareta, Sunyer, Jordi, Nielsen, Jeanette K., Merlo, Domenico F., Mendez, Michelle A., Meltzer, Helle M., Lukács, Viktória, Landström, Anette, Kyrtopoulos, Soterios A., Kovács, Katalin, Knudsen, Lisbeth E., Haugen, Margaretha, Hardie, Laura J., Gützkow, Kristine B., Fleming, Sarah, Fthenou, Eleni, Farmer, Peter B., Espinosa, Aina, Chatzi, Leda, Brunborg, Gunnar, Brady, Nigel J., Botsivali, Maria, Arab, Khelifa, Anna, Lívia, Alexander, Jan, Agramunt, Silvia, Kleinjans, Jos C., Segerbäck, Dan, Kogevinas, Manolis“…Evidence from biomarker-based studies of low-exposed populations is limited. Bulky DNA adducts in cord blood reflect the prenatal effective dose to several genotoxic agents including PAHs. …”
Publicado 2013
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116728por Gaggioli, Andrea, Pallavicini, Federica, Morganti, Luca, Serino, Silvia, Scaratti, Chiara, Briguglio, Marilena, Crifaci, Giulia, Vetrano, Noemi, Giulintano, Annunziata, Bernava, Giuseppe, Tartarisco, Gennaro, Pioggia, Giovanni, Raspelli, Simona, Cipresso, Pietro, Vigna, Cinzia, Grassi, Alessandra, Baruffi, Margherita, Wiederhold, Brenda, Riva, Giuseppe“…METHODS: The study was designed as a block randomized controlled trial involving 121 participants recruited from two different worker populations—teachers and nurses—that are highly exposed to psychological stress. Participants were a sample of teachers recruited in Milan (Block 1: n=61) and a sample of nurses recruited in Messina, Italy (Block 2: n=60). …”
Publicado 2014
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116729por Mansouri, Kamel, Abdelaziz, Ahmed, Rybacka, Aleksandra, Roncaglioni, Alessandra, Tropsha, Alexander, Varnek, Alexandre, Zakharov, Alexey, Worth, Andrew, Richard, Ann M., Grulke, Christopher M., Trisciuzzi, Daniela, Fourches, Denis, Horvath, Dragos, Benfenati, Emilio, Muratov, Eugene, Wedebye, Eva Bay, Grisoni, Francesca, Mangiatordi, Giuseppe F., Incisivo, Giuseppina M., Hong, Huixiao, Ng, Hui W., Tetko, Igor V., Balabin, Ilya, Kancherla, Jayaram, Shen, Jie, Burton, Julien, Nicklaus, Marc, Cassotti, Matteo, Nikolov, Nikolai G., Nicolotti, Orazio, Andersson, Patrik L., Zang, Qingda, Politi, Regina, Beger, Richard D., Todeschini, Roberto, Huang, Ruili, Farag, Sherif, Rosenberg, Sine A., Slavov, Svetoslav, Hu, Xin, Judson, Richard S.“…BACKGROUND: Humans are exposed to thousands of man-made chemicals in the environment. …”
Publicado 2016
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116730por Le Pogam, Marie-Annick, Quantin, Catherine, Reich, Oliver, Tuppin, Philippe, Fagot-Campagna, Anne, Paccaud, Fred, Peytremann-Bridevaux, Isabelle, Burnand, Bernard“…BACKGROUND: Frail older people with multiple interacting conditions, polypharmacy, and complex care needs are particularly exposed to health care-related adverse events. Among these, anticoagulant-related thromboembolic and hemorrhagic events are particularly frequent and serious in older inpatients. …”
Publicado 2017
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116731por de Lusignan, Simon, McGee, Christopher, Webb, Rebecca, Joy, Mark, Byford, Rachel, Yonova, Ivelina, Hriskova, Mariya, Matos Ferreira, Filipa, Elliot, Alex J, Smith, Gillian, Rafi, Imran“…OBJECTIVE: The objective of the study was to assess differences in general practice presentations of allergic and infectious disease in those exposed to conurbation or urban living compared with rural environments. …”
Publicado 2018
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116732por Varone, Alessia, Mariggiò, Stefania, Patheja, Manpreet, Maione, Vincenzo, Varriale, Antonio, Vessichelli, Mariangela, Spano, Daniela, Formiggini, Fabio, Lo Monte, Matteo, Brancati, Nadia, Frucci, Maria, Del Vecchio, Pompea, D’Auria, Sabato, Flagiello, Angela, Iannuzzi, Clara, Luini, Alberto, Pucci, Piero, Banci, Lucia, Valente, Carmen, Corda, Daniela“…As a consequence, fibroblast cells exposed to GroPIns4P show significantly enhanced wound healing capability, indicating that GroPIns4P has a stimulatory role to activate fibroblast migration. …”
Publicado 2019
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116733por Witkowski, Marco, Witkowski, Mario, Saffarzadeh, Mona, Friebel, Julian, Tabaraie, Termeh, Ta Bao, Loc, Chakraborty, Aritra, Dörner, Andrea, Stratmann, Bernd, Tschoepe, Diethelm, Winter, Samantha J., Krueger, Andreas, Ruf, Wolfram, Landmesser, Ulf, Rauch, Ursula“…In vitro, human microvascular endothelial cells (HMEC)-1 and human monocytes (THP-1) were transfected with miR-181b or anti-miR-181b and exposed to tumor necrosis factor (TNF) α or lipopolysaccharides (LPS). …”
Publicado 2020
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116734por Welch, Barrett M., Branscum, Adam, Geldhof, G. John, Ahmed, Sharia M., Hystad, Perry, Smit, Ellen, Afroz, Sakila, Megowan, Meghan, Golam, Mostofa, Sharif, Omar, Rahman, Mahmuder, Quamruzzaman, Quazi, Christiani, David C., Kile, Molly L.“…BACKGROUND: Many populations are exposed to arsenic, lead, and manganese. These metals influence immune function. …”
Publicado 2020
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116735por Semengue, Ezechiel Ngoufack Jagni, Santoro, Maria Mercedes, Ndze, Valantine Ngum, Dambaya, Beatrice, Takou, Desiré, Teto, Georges, Nka, Alex Durand, Fabeni, Lavinia, Wiyeh, Alison, Ceccherini-Silberstein, Francesca, Colizzi, Vittorio, Perno, Carlo-Federico, Fokam, Joseph“…We will include studies of adults and/or children exposed to integrase inhibitors-based therapies; especially dolutegravir or raltegravir (which is our intervention of interest as compared to other antiretroviral regimens). …”
Publicado 2020
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116736por Lozano, Omar, Silva-Platas, Christian, Chapoy-Villanueva, Héctor, Pérez, Baruc E., Lees, Jarmon G., Ramachandra, Chrishan J. A., Contreras-Torres, Flavio F., Lázaro-Alfaro, Anay, Luna-Figueroa, Estefanía, Bernal-Ramírez, Judith, Gordillo-Galeano, Aldemar, Benitez, Alfredo, Oropeza-Almazán, Yuriana, Castillo, Elena C., Koh, Poh Ling, Hausenloy, Derek J., Lim, Shiang Y., García-Rivas, Gerardo“…The activity of aconitase and thiol oxidation, in the adenine nucleotide translocase, were found to be reduced due to nanoSiO(2) exposure, suggesting that nanoSiO(2) induces the mPTP via thiol modification and ROS generation. In cardiac cells exposed to nanoSiO(2), enhanced viability and reduction of H(2)O(2) were observed after application of a specific mitochondrial antioxidant, MitoTEMPO. …”
Publicado 2020
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116737por Alonge, Olakunle, Bishai, David, Wadhwaniya, Shirin, Agrawal, Priyanka, Rahman, Aminur, Dewan Hoque, Emdad Md., Baset, Kamran Ul, Salam, Shumona Sharmin, Bhuiyan, Al-Amin, Islam, Md Irteja, Talab, Abu, Rahman, Qazi Sadeq-ur, Rahman, Fazlur, El-Arifeen, Shams, Hyder, Adnan A.“…RESULTS: A total of 3205 creches (average of 7 creches per village) were established, and 116,054 children aged 9–47 months were exposed to the intervention packages. Aggregated drowning IRs between age 0 and 47 were estimated per 100,000 population per year at 86.73 (95% CI: 69.67–107.97) and 43.03 (95% CI: 35.55–52.10) in the baseline and post implementation period, respectively. …”
Publicado 2020
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116738por Healy, Genevieve Nissa, Goode, Ana D, Abbott, Alison, Burzic, Jennifer, Clark, Bronwyn K, Dunstan, David W, Eakin, Elizabeth G, Frith, Matthew, Gilson, Nicholas D, Gao, Lan, Gunning, Lynn, Jetann, Jodie, LaMontagne, Anthony D, Lawler, Sheleigh P, Moodie, Marjory, Nguyen, Phuong, Owen, Neville, Straker, Leon, Timmins, Perri, Ulyate, Lisa, Winkler, Elisabeth A H“…A minimum of 50 work teams will be recruited per priority sector with a minimum of 10,000 employees exposed to the program. A single-arm, repeated-measures design will assess the short-term (end of program) and long-term (9 months postprogram) impacts. …”
Publicado 2020
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116739por Allin, Leigh J., Brolinson, P. Gunnar, Beach, Briana M., Kim, Sunwook, Nussbaum, Maury A., Roberto, Karen A., Madigan, Michael L.“…Assessments involved exposing participants to an unexpected laboratory-induced slip or trip. …”
Publicado 2020
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116740por Jung-Schroers, Verena, Hildebrandt, Uta, Retter, Karina, Esser, Karl-Heinz, Hellmann, John, Kleingeld, Dirk Willem, Rohn, Karl, Steinhagen, Dieter“…A stage of insensibility could safely be induced by exposing portion-sized rainbow trout to an electric current density above 0.1 A dm(2). …”
Publicado 2020
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