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  1. 117361
    “…Hog1 (P = .0012) and Cta1 (P = .01) transcript levels were highly elevated in flu-susceptible isolates when exposed to 10 mm of H2O2 while no significant difference was observed in resistant isolates. …”
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    P005 Competitive fitness and trade-offs associated with azole resistance in Candida auris clinical isolates
  2. 117362
    “…RESULTS: The results of the simulated group sequential designs showed that for two of the RCTs it was highly likely that they would have stopped for futility at interim analyses, potentially saving considerable time (15 and 23 months) and costs and avoiding patients being exposed to interventions that were either ineffective or no better than standard care. …”
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    Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs
  3. 117363
    “…In humans, PSMA-TO-1 dosimetry estimates suggest increased tumor absorbed doses; however, the kidneys, salivary glands and bone marrow are also exposed to higher radiation doses. Thus, additional preclinical studies are needed before further clinical use. …”
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    Comparison of PSMA-TO-1 and PSMA-617 labeled with gallium-68, lutetium-177 and actinium-225
  4. 117364
    “…The operated thighs of 10 patients were exposed weekly to PEMFs (1 ​mT for 10 ​min) for 4 months following surgery. …”
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    Magnetic field therapy enhances muscle mitochondrial bioenergetics and attenuates systemic ceramide levels following ACL reconstruction: Southeast Asian randomized-controlled pilot trial
  5. 117365
    “…In the first 2 study sites, participants were exposed to the early phases of the COVID-19 pandemic, which included disruption to their regular SCD care. …”
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    Impact of the COVID-19 Pandemic on the Implementation of Mobile Health to Improve the Uptake of Hydroxyurea in Patients With Sickle Cell Disease: Mixed Methods Study
  6. 117366
    “…Of 3 223 580 individuals drawn from 13 studies, those who were exposed to care in childhood had twice the risk of total mortality in adulthood relative to those without a history of care in childhood (summary risk ratio 2·21 [95% CI 1·62–3·02]), with study-specific estimates varying between 1·04 and 5·77 (I(2) =98%). …”
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    State care in childhood and adult mortality: a systematic review and meta-analysis of prospective cohort studies
  7. 117367
    “…PTEN protein was unaffected by miR-21 inhibition.In further experiments, transfected cells were exposed to BPA, and apoptosis was examined. Using Annexin V/PI staining, a significant decrease in healthy cells and an increase in early apoptotic cells within inhibited untreated groups was shown (p=0.0395 and 0.0193, n=3). …”
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    RF22 | PMON08 The effects of Bisphenol A on miR-21 expression and miR-21 mediated apoptosis in bovine granulosa cells.
  8. 117368
    “…Female ovariectomised Vgat-cre mice (n=7) were virally infected to selectively express inhibitory hM4DGi-DREADDs in MePD GABA neurones. Mice were exposed to either predator odour (PO) or restraint stress and given an intraperitoneal injection of either saline or the DREADD chemical activator clozapine-N-oxide (CNO, 5mg/kg). …”
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    OR17-2 GABAergic Signalling in the Posterodorsal Medial Amygdala Mediates Psychological Stress-induced Suppression of the GnRH Pulse Generator in Female Mice
  9. 117369
    “…These results suggest that PDL-1 has a protective role in the thyroid against inflammatory stressors, and that its blockade exposes the thyroid to inflammatory damage. Therefore, in patients undergoing αPD-L1 therapy, inflammatory conditions (e.g. infections) can be a "second hit" that accelerates the onset of thyroiditis and augments thyroidal inflammation. …”
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    OR19-5 Dissecting Thyroidal Pathways Activated by PD-L1 Blockade Identifies New Mechanisms for Thyroiditis Triggered by Immune Checkpoint Inhibitors
  10. 117370
    “…Notably, EVs from 24h E2-treated KTaV-3 neurons induced increased expression of kiss1r in GT1-7 cells, in contrast to KTaV-3 neurons not exposed to E2, suggesting that AVPV KP neurons may signal an increase in KP receptivity in GnRH neurons in vivo via non-neuronal communication. …”
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    PMON54 Exosomes Isolated from Conditioned Media of Immortalized Kisspeptin Neurons Exert Diverse Effects on Central and Peripheral in Vitro Cell Models.
  11. 117371
    por Goyal, Varunika
    Publicado 2022
    “…Female C3H-f+∕+ (WT) and C3H-f+∕+ MT1 KO (MT1KO) mice (n=9-12/group) at six weeks of age were housed singly and exposed to CD (D12450H, 10% kcal/fat) or HFD (D12451, 45% kcal/fat) for 14 weeks. …”
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    OR22-5 Effect of Melatonin Receptor 1 on Glucose and Lipid Metabolism in Melatonin-proficient (c3hf+ ∕+) Female Mice
  12. 117372
    “…Very little is known about the extent to which the Tanzanian population has been exposed to SARS-CoV-2. Here, we investigated the seroprevalence of IgG to SARS-CoV-2 spike protein in two Tanzanian rural communities 1½ years into the pandemic and the association of coinciding malaria infection and exposure. …”
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    Seroprevalence of SARS-CoV-2 antibodies among children and adolescents recruited in a malariometric survey in north-eastern Tanzania July 2021
  13. 117373
    “…ChIP assays for PARP1 binding in cells showed a (30-fold enrichment ±3.2SEM) at GR response elements and detectable ADPR was reduced when exposed to dexamethasone (Western immunoblot n=5). …”
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    OR07-5 PARP1 Contributes to the Glucocorticoid Receptor Transcriptional Response And Influences the Skeletal Muscle Phenotype
  14. 117374
    “…FINDINGS: The study population consisted of 240 patients diagnosed with COVID-19 between January 2020 and February 2022 exposed to ICI within 3 months prior to COVID-19 diagnosis, with a 30-day case fatality rate (CFR(30)) of 23.6% (95% CI 17.8 to 30.7%). …”
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    Immune checkpoint inhibitor therapy and outcomes from SARS-CoV-2 infection in patients with cancer: a joint analysis of OnCovid and ESMO-CoCARE registries
  15. 117375
    por Staccini, Pascal, Lau, Annie Y.S.
    Publicado 2022
    “…Beyond the classic health issues targeted by social media (e.g., influencing health behaviors, from smoking and diet adherence to preventative screening and exercise habits), the pandemic has exposed many situations of vulnerability and health inequality. …”
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    Consuming Health Information and Vulnerable Populations: Factors of Engagement and Ongoing Usage
  16. 117376
    “…OBJECTIFS: Les modifications organisationnelles liées à la crise sanitaire COVID-19 (cours en distanciel et stage en service d’unités COVID pour certains externes) ont pu favoriser la détresse psychologique des étudiants inscrits en médecine habituellement exposés à une charge de travail intense. L’objectif de cette étude était d’évaluer la prévalence de la détresse psychologique chez les étudiants en médecine pendant la crise sanitaire du COVID-19, et d’identifier les facteurs associés à la détresse psychologique. …”
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    Facteurs associés à la détresse psychologique des étudiants en médecine lors de la crise sanitaire de la COVID-19 : une étude transversale
  17. 117377
    “…METHODS: oxPTM-INS was generated by exposing insulin to various reactive oxidants. The insulin fragments resulting from oxPTM were fractionated by size-exclusion chromatography further to ELISA and LC-MS/MS analysis to identify the oxidised peptide neoepitopes. …”
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    Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes
  18. 117378
    “…We operationalized Reach as the number and demographics of women enrolled in NFP agencies exposed to MHI strategies. Adoption was operationalized as the number and proportion of nurses and supervisors who used MHI implementation strategies. …”
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    Implementing mental health interventions within a national nurse home visiting program: A mixed-methods evaluation
  19. 117379
    “…Thus, the current investigation designed to assess the antidepressant activity of the standardized hydroethanolic extract of Aegle marmelos (EAM) leaves in male rats exposed to the chronic unpredictable mild stress (CUMS) paradigm. …”
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    Antidepressive-Like Effect of Aegle marmelos Leaf Extract in Chronic Unpredictable Mild Stress-Induced Depression-Like Behaviour in Rats
  20. 117380
    “…On the other hand, findings from a separate analysis using structured lifecourse modelling approaches also highlight the vital developmental timeframes in childhood during which the impact of adversity exposure on cognitive outcomes is greatest, suggesting the need to provide comprehensive academic and mental health support to individuals exposed during those specific timeframes. FUNDING: T.N. received funding from 10.13039/501100003343Cambridge Trust (10.13039/501100000735University of Cambridge).…”
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    Cognitive variations following exposure to childhood adversity: Evidence from a pre-registered, longitudinal study
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