Mostrando 21 - 40 Resultados de 129 Para Buscar '"FHM"', tiempo de consulta: 0.14s Limitar resultados
  1. 21
    “…Familial hemiplegic migraine type 1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) calcium channels. …”
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    Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in Ca(V)2.1 knockin migraine mice
  2. 22
    “…We generated the first FHM2 knock-in mouse model carrying the human W887R mutation in the Atp1a2 orthologous gene. …”
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    Increased Susceptibility to Cortical Spreading Depression in the Mouse Model of Familial Hemiplegic Migraine Type 2
  3. 23
    “…It is well described that FHM1 can present with cerebellar signs, but parkinsonism has not previously been reported in FHM1 or EA2 even though parkinsonism has been described in SCA6. …”
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    Familial Hemiplegic Migraine Type 1 Associated with Parkinsonism: A Case Report
  4. 24
    “…INTRODUCTION: Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura. …”
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    Early-onset familial hemiplegic migraine due to a novel SCN1A mutation
  5. 25
    “…Both processes are essential for proper brain activity, and autosomal dominantly mutations in the ATP1A2 gene cause the neurological disorder Familial hemiplegic migraine type 2 (FHM2). FHM2 is a severe subtype of migraine with aura including temporary numbness or weakness, and affecting only one side of the body. …”
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    Insights into the Pathology of the α(2)-Na(+)/K(+)-ATPase in Neurological Disorders; Lessons from Animal Models
  6. 26
    “…BACKGROUND: Familial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. …”
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    Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene
  7. 27
    “…CONCLUSIONS: We found that multiple factors, including gender, household income, and body mass index, were correlated with latent FHM during home quarantine. We conclude that FHM can meaningfully improve individuals’ health. …”
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    Current status and influential factors for family health management during quarantine: A latent category analysis
  8. 28
    por Montagna, Pasquale
    Publicado 2008
    “…However, a review of the genetic studies suggests that the FHM genes are not involved in the typical migraines and that FHM should be considered as a syndromic migraine rather than a subtype of MA. …”
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    The primary headaches: genetics, epigenetics and a behavioural genetic model
  9. 29
    “…We present a Norwegian family with familial hemiplegic migraine (FHM) with possibly four affected in three generations. …”
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    Intravenous nimodipine worsening prolonged attack of familial hemiplegic migraine
  10. 30
    “…RATIONALE: Familial hemiplegic migraine (FHM) is a rare, autosomal dominant migraine with aura. …”
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    Next-generation sequencing identified a novel CACNA1A I1379F variant in a familial hemiplegic migraine type 1 pedigree: A case report
  11. 31
    por Montagna, Pasquale
    Publicado 2001
    “…FHM is allelic with episodic ataxia type 2 and spinocerebellar ataxia type 6. …”
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    The genetics of migraine
  12. 32
    “…We show that knock-in mice heterozygous for the FHM2-associated G301R-mutation (α(2)(+/G301R)) phenocopy several FHM2-relevant disease traits e.g., by mimicking mood depression and OCD. …”
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    Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model
  13. 33
    “…INTRODUCTION: Neuropsychological symptoms are rare in familial hemiplegic migraine (FHM). There are no reports of psychotic symptoms in FHM type 2 (ATP1A2). …”
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    Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2)
  14. 34
    “…Nuclear HMGB1 release in the cortex of FHM1 mutant mice, at 30 min after CSD, was increased bilaterally in both WT and FHM1 mutant mice, albeit that contralateral release was more pronounced in the mutant mice. …”
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    Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice
  15. 35
    “…SHM cases experienced more prolonged attacks than FHM cases, with significantly longer duration of both motor aura and of total HM attack. …”
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    First Attack and Clinical Presentation of Hemiplegic Migraine in Pediatric Age: A Multicenter Retrospective Study and Literature Review
  16. 36
    “…Familial hemiplegic migraine (FHM) is an autosomal dominant disorder, classified into 3 subtypes, based on the gene involved (CACNA1A in FHM1, ATP1A2 in FHM2 and SCN1A in FHM3). …”
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    CACNA1A-p.Thr501Met mutation associated with familial hemiplegic migraine: a family report
  17. 37
    “…Mutations in four genes have been identified in familial hemiplegic migraine (FHM), from which CACNA1A (FHM type 1) and SCN1A (FHM type 3) code for neuronal voltage-gated calcium or sodium channels, respectively, while ATP1A2 (FHM type 2) encodes the α(2) isoform of the Na(+),K(+)-ATPase's catalytic subunit, thus classifying FHM primarily as an ion channel/ion transporter pathology. …”
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    ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of Disease
  18. 38
    “…Here, we report the characterization of the L1670W SCN1A mutation that has been previously identified in a Chinese family with pure FHM-3, and that we have identified also in a Caucasian American family with pure FHM-3. …”
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    Gain of Function for the SCN1A/hNa(v)1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine
  19. 39
    “…Additionally, we reproduced in silico the obtained experimental results with a novel spiking neurons network model of mouse V1, by implementing in the model both the synaptic alterations characterizing the FHM1 genetic mouse model adopted. RESULTS: FHM1 mice displayed similar amplitude but slower temporal evolution of visual evoked potentials. …”
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    Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine
  20. 40
    “…The ATP1A2 coding α2 subunit of Na,K‐ATPase, which is predominantly located in astrocytes, is a causative gene of familial hemiplegic migraine type 2 (FHM2). FHM2 model mice (Atp1a2(tmCKwk/+)) are susceptible to cortical spreading depression (CSD), which is profoundly related to migraine aura and headache. …”
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    Astrocytes in Atp1a2‐deficient heterozygous mice exhibit hyperactivity after induction of cortical spreading depression
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