Mostrando 41 - 60 Resultados de 129 Para Buscar '"FHM"', tiempo de consulta: 0.34s Limitar resultados
  1. 41
    “…The study describes the efficiency of iron oxide coated hollow poly(methyl methacrylate) microspheres (FHM) as an adsorptive media for the removal of arsenic from water. …”
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    Iron oxide coated hollow poly(methylmethacrylate) as an efficient adsorption media for removal of arsenic from water
  2. 42
    “…Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. A mutation causing FHM type 3 (FHM3) has been identified in SCN1A encoding the Nav1.1 Na(+) channel. …”
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    Linking a genetic defect in migraine to spreading depression in a computational model
  3. 43
    “…Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (‘FHM1 R192Q mice’) exhibit an increased susceptibility to cortical spreading depression (CSD), the mechanism underlying migraine aura. …”
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    Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine
  4. 44
    “…Here, we investigated the cortical layer 2/3 (L2/3) feedback inhibition microcircuit involving somatostatin-expressing (SOM) INs in FHM1 mice of both sexes carrying a gain-of-function mutation in Ca(V)2.1. …”
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    Enhanced Feedback Inhibition Due to Increased Recruitment of Somatostatin-Expressing Interneurons and Enhanced Cortical Recurrent Excitation in a Genetic Mouse Model of Migraine
  5. 45
    “…Familial hemiplegic migraine type 3 (FHM3) is caused by gain-of-function mutations in the SCN1A gene that encodes the α1 subunit of voltage-gated Na(V)1.1 sodium channels. …”
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    Deciphering in silico the Role of Mutated Na(V)1.1 Sodium Channels in Enhancing Trigeminal Nociception in Familial Hemiplegic Migraine Type 3
  6. 46
    “…Therefore, we studied both FHM-3 and epileptogenic mutations within the same framework, modifying only two parameters. …”
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    Modeling Na(V)1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine
  7. 47
    “…Mutations affecting the Na(+), K(+) ATPase alpha subunit have been implicated in at least two distinct human diseases, rapid-onset dystonia Parkinsonism (RDP), and familial hemiplegic migraine (FHM). Over 40 mutations have been mapped to the human ATP1A2 and ATP1A3 genes and are known to result in RDP, FHM or a variant of FHM with neurological complications. …”
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    Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity
  8. 48
    “…The flumazenil binding in the temporal cortex was also decreased in two FHM1 patients. CONCLUSIONS: Cerebellar glucose hypometabolism and an altered GABA-A receptor function are characteristic of FHM1 and SCA6. …”
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    An altered GABA-A receptor function in spinocerebellar ataxia type 6 and familial hemiplegic migraine type 1 associated with the CACNA1A gene mutation
  9. 49
    “…Familial hemiplegic migraine type 1 (FHM1) is a rare migraine subtype. Whereas transgenic knock-in mice with the human pathogenic FHM1 R192Q missense mutation in the Cacna1a gene reveal overall neuronal hyperexcitability, the effects on the trigeminovascular system and calcitonin gene-related peptide (CGRP) receptor are largely unknown. …”
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    Trigeminovascular calcitonin gene-related peptide function in Cacna1a R192Q-mutated knock-in mice
  10. 50
    “…Four levels of Flemingia hay meal (FHM) were used to replace soybean meal (SBM) in the concentrate mixtures in four dietary treatments replacing levels at 0%, 30%, 60%, and 100% of SBM. …”
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    Potential use of Flemingia (Flemingia macrophylla) as a protein source fodder to improve nutrients digestibility, ruminal fermentation efficiency in beef cattle
  11. 51
    “…Familial hemiplegic migraine (FHM) type 1 is a rare monogenic dominant autosomal disease due to CACNA1A gene mutations. …”
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    R583Q CACNA1A variant in SHM1 and ataxia: case report and literature update
  12. 52
    “…Migraine with aura (MA) also encompasses a rare severe subtype Familial Hemiplegic Migraine (FHM) with several known genetic loci. The type 2 FHM (FHM-2) susceptibility locus maps to chromosome 1q23 and mutations in the ATP1A2 gene at this site have recently been implicated. …”
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    Association analysis of chromosome 1 migraine candidate genes
  13. 53
    “…This report also adds knowledge to the clinical spectrum of SCN1A alterations and suggests a potential overlap between MRS and FHM.…”
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    Melkersson–Rosenthal Syndrome and Migraine: A New Phenotype Associated with SCN1A Variants?
  14. 54
    “…Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. …”
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    Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1
  15. 55
    “…BACKGROUND: Familial clustering of lymphoid and/or hematological malignancies (FHM) provides an opportunity to study the responsible genes. …”
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    Risk of hematological malignancies in the families of patients treated for nodular lymphocyte-predominant Hodgkin lymphoma
  16. 56
    “…The FH+ group included 50 subjects with maternal (FHm) and 30 with paternal family history (FHp). …”
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    FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer’s Disease
  17. 57
    “…Familial hemiplegic migraine type 1 (FHM1) is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) Ca(2+) channels. …”
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    Abnormal cortical synaptic transmission in Ca(V)2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans
  18. 58
    “…Our results provide the mechanism linking Na(V)1.1 gain of function to CSD generation in FHM3. Thus, we reveal the key role of hyperactivity of GABAergic interneurons in a mechanism of CSD initiation, which is relevant as a pathological mechanism of Na(v)1.1 FHM3 mutations, and possibly also for other types of migraine and diseases in which SDs are involved.…”
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    Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and Na(V)1.1 channels
  19. 59
    “…Familial hemiplegic migraine (FHM) is a rare disorder characterized by migraine attacks with motor weakness during the aura phase. …”
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    Familial Hemiplegic Migraine with Severe Attacks: A New Report with ATP1A2 Mutation
  20. 60
    “…Non-polyglutamine CACNA1A variants underlie familial hemiplegic ataxia type 1 (FHM1) and episodic ataxia type 2 (EA2). Classical paroxysmal manifestations of FHM1 are migraine attacks preceded by motor aura consisting of hemiparesis, aphasia, and disturbances of consciousness until coma. …”
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    From Genotype to Phenotype: Expanding the Clinical Spectrum of CACNA1A Variants in the Era of Next Generation Sequencing
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