“…Patients suffering from familial hemiplegic migraine type 1 (FHM1) may have a disproportionally severe outcome after head trauma, but the underlying mechanisms are unclear. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: The presence of SCN1A mutations and absence of mutations in ATP1A2 or CACNA1A suggest that the Polish patients represent FHM type 3. On the other hand, the presence of KCNK18 mutation indicated another FHM subtype. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: 85 EEG recordings from 38 patients (19 EA2, 14 FHM1, 5 SCA6) were analyzed. Baseline EEG was abnormal in 55% of cases (12 EA2, 9 FHM1). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Spinocerebellar ataxia type 6 (SCA6), episodic ataxia type 2 (EA2) and familial hemiplegic migraine (FHM) have been known as allelic disorders, which are caused by the alteration of the alpha1A voltage-dependent calcium channel subunit. …”
Enlace del recurso
Enlace del recurso

“…The mechanism of CSD, stemming in part from aberrant interactions between neurons and glia have been studied in models of familial hemiplegic migraine (FHM), a rare monogenic form of migraine with aura. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we investigated whether, in trigeminal sensory ganglia, cytokines such as TNFα might contribute to a local inflammatory phenotype of a transgenic knock-in (KI) mouse model of familial hemiplegic migraine type-1 (FHM-1). To this end, macrophage occurrence and cytokine expression in trigeminal ganglia were compared between wild type (WT) and R192Q mutant Ca(V)2.1 Ca(2+) channel (R192Q KI) mice, a genetic model of FHM-1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: A 5-day fathead minnow (FHM) spawning assay is used by industry to monitor pulp mill effluent quality, with some mill effluents capable of completely inhibiting spawning. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among those, different mass spectral features showed significant (t-test, P < 0.05) changes in the cortex, 146 and 377 Da, and in the thalamus, 1820 and 1834 Da, of the CSD-affected hemisphere of FHM1 R192Q mice. Our findings reveal CSD- and genotype-specific molecular changes in the brain of FHM1 transgenic mice that may further our understanding about the role of CSD in migraine pathophysiology. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CASE PRESENTATION: We describe an Italian family with FHM and a missense ATP1A2 variant (L425H) not previously described. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MM was also found to correlate with a reduced risk for NEC (OR 0.148, 95% CI 0.044–0.05, p = 0.02), and in particular, on day 14, several factors were related to a decreased odd for NEC, including birth weight, antenatal steroids, and the use of FHM (p < 0.001). (4) Conclusions: MM and FHM were associated with less NEC compared to fasting on days 7 and 14. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An Italian family with familial hemiplegic migraine (FHM) with the absence of mutations in the known genes associated with this disorder, namely ATP1A2, ATP1A3, CACNA1A, and SCN1A, has recently been reported. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The addition of MCT to fortified human milk (FHM) did not affect its osmolality. CONCLUSIONS: Changes of osmolality in the 72 h following fortification of both DHM and MOM did not exceed the safety values supporting the theoretically possibility of preparing 72 h volumes of FHM. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results: Whole-exome sequencing revealed the R583Q missense mutation in the CACNA1A gene in the two patients with hemiplegic migraine and cerebellar ataxia with atrophy, confirming a FHM1 disorder. Two further patients did not have the mutation and suffered from migraine with aura. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Following a FV3 infection in fathead minnow (FHM) cells 75L was found in vesicles throughout the cytoplasm as early as 3 hours post-infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Since monogenic mi-graines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FHM) patients have been gen-erated. Studies in these FHM mutant mice models have shed light on the mechanisms of migraine and may aid in the identifi-cation of novel targets for treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using fluorescent glutamate imaging, we show that awake mice carrying a familial hemiplegic migraine type 2 (FHM2) mutation have slower clearance during sensory processing, as well as previously undescribed spontaneous “plumes” of glutamate. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The PHT method consists of two aspects: random hybrid augmentation (RHA) and a feature hybrid mechanism (FHM). Regarding RHA, an image random cropper and a local region hybrider are designed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The progressive cytoskeletal alterations of frog virus 3-infected baby hamster kidney (BHK) and fathead minnow (FHM) cells were studied by immunofluorescence and electron microscopy. …”
Enlace del recurso
Enlace del recurso

“…DLs incubated at pH 7.0 for 9 days strongly inhibited growth of S. sonnei (92.9%). Fathead minnow (FHM) cells were infected with VHSV. DLs treated at all pHs for 1 day resulted in more than 80% viability of VHSV-infected FHM cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Herein, the authors synthesize ferrous ions, histidine, and MTX assembled nanoparticles (FHM) to deliver MTX at tumor site and enhance the sensitivity of tumor cells to MTX with histidine catabolism. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso