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  1. 2161
    “…In a previous study we identified a group of genes, which we considered the bona fide targets of Hog1, because they were induced in response to expression of intrinsically active mutant of Hog1, in the absence of any stress. …”
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    Hog1-induced transcription of RTC3 and HSP12 is robust and occurs in cells lacking Msn2, Msn4, Hot1 and Sko1
  2. 2162
    “…Among the GGDPS family of the two Melampsora species experimentally characterized, one enzyme was verified to be bona fide GGDPS and all others were demonstrated to function as TPSs. …”
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    Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi
  3. 2163
    “…However, we show here that if both EFG1 and WOR1 are deleted simultaneously, bona fide opaque cells can still be induced en masse. …”
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    Candida albicans Double Mutants Lacking both EFG1 and WOR1 Can Still Switch to Opaque
  4. 2164
    “…In particular, uninfectious but propagative PrP amyloid can transform into a bona fide infectious conformer, PrP(Sc) through deformed templating. …”
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    Modeling PrP(Sc) Generation Through Deformed Templating
  5. 2165
    “…Some loss-of-function variants impair the folding and intracellular trafficking of the protein (thus retaining the transporter in the endoplasmic reticulum compartment), whereas others, despite managing to reach their bona fide site of action at the cell surface, nonetheless abolish GABA transport activity (plausibly owing to structural/conformational defects). …”
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    Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders
  6. 2166
    “…Collectively, our findings shed new light on the mechanism and function of mitochondrial PDIP38, demonstrating that PDIP38 is a bona fide adaptor protein for the mitochondrial protease, CLPXP.…”
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    Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP
  7. 2167
    “…This study correlates the readiness survey scores of bona fide first year university students with their success in a mathematically based first year module. …”
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    Relating student perceptions of readiness to student success: A case study of a mathematics module
  8. 2168
    “…We discovered 19,475 bona fide viral sequences, which are derived from viruses predicted to infect abundant and ecologically important taxa that reside in Lake Baikal, such as Nitrospirota, Methylophilaceae, and Crenarchaeota. …”
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    New viral biogeochemical roles revealed through metagenomic analysis of Lake Baikal
  9. 2169
    “…However, not all chemotherapeutic drugs currently approved for cancer treatment are able to stimulate bona fide ICD: some commonly used agents, such as cisplatin or 5-fluorouracil, are unable to activate all features of ICD. …”
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    Dynamical Boolean Modeling of Immunogenic Cell Death
  10. 2170
    “…RESULTS: ΔHBc and wild-type (WT) HBV resulted in comparable expression of HBV surface antigen (HBsAg), which could be blocked using the entry inhibitor Myrcludex B, confirming bona fide infection via the receptor sodium taurocholate cotransporting polypeptide (NTCP). …”
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    De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA
  11. 2171
    “…Here we report that mice with a brain EC-specific deletion of Pdcd10 (Pdcd10(BECKO)) survive up to 6-12 months and develop bona fide CCM lesions in all regions of brain, allowing us to visualize the vascular dynamics of CCM lesions using transcranial two-photon microscopy. …”
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    Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
  12. 2172
    “…To investigate whether virus-encoded proteases target ULK1, we conducted in-vitro and cellular cleavage assays and identified ULK1 as a novel bona fide substrate of SARS-CoV-2 papain-like protease (PL(pro)). …”
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    The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy
  13. 2173
    “…Purification of tdTomato+ and CFP+ CMs using flow cytometry coupled with transcriptional and functional characterization validated these genetic tools for their use in the isolation of bona fide ventricular-like and atrial-like CMs, respectively. …”
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    CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes
  14. 2174
    por Hicks, Julie A., Liu, Hsiao-Ching
    Publicado 2021
    “…As adipose tissue is well known to produce inflammatory and other immune factors, we used SPF white leghorns to generate the initial miRNome and transcriptome signatures to minimize complications from external factors (e.g., pathogenic infections) and ensure the identification of bona fide switch-associated miRNAs and transcripts. We then examined their expression signatures in the adipose tissue of broilers (Ross 708). …”
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    Expression Signatures of microRNAs and Their Targeted Pathways in the Adipose Tissue of Chickens during the Transition from Embryonic to Post-Hatch Development
  15. 2175
    “…While having lost a bona fide Hedgehog gene, most nematodes have evolved an expanded repertoire of Hedgehog-related genes, ten of which reside within the Warthog family. …”
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    Extensive non-redundancy in a recently duplicated developmental gene family
  16. 2176
    por Lai, Alex L., Freed, Jack H.
    Publicado 2021
    “…We previously determined that the sequence immediately downstream from the S2′ cleavage site is the bona fide SARS-1 FP. In this study, we used sequence alignment to identify the SARS-2 FP, and studied its membrane ordering effect. …”
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    SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca(2+)
  17. 2177
    “…Being a member of the miR-34 family, miR-34a was identified as a p53 target in 2007. It is a bona fide tumor suppressor, and its expression is dysregulated and downregulated in various human cancers. …”
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    MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic
  18. 2178
    “…Through integrated RNA sequencing, target prediction, and functional assays, we identified the transcription factors MAFG and MYBL2 as bona fide miR-29 targets in melanoma. Our findings suggest that attenuation of miR-29b2~c expression promotes melanoma development, at least in part, by derepressing MAFG and MYBL2.…”
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    A MAPK/miR-29 Axis Suppresses Melanoma by Targeting MAFG and MYBL2
  19. 2179
    “…We previously observed that some CD14(+) myeloid cells expressed CD1c, a pan marker for bona fide conventional DC2 (cDC2s), in humanized mouse models in which human FLT3L and GM-CSF genes were transiently expressed using in vivo transfection (IVT). …”
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    Development of an Inflammatory CD14(+) Dendritic Cell Subset in Humanized Mice
  20. 2180
    “…Genomic features of HRD and biallelic alterations affecting bona fide HRD‐related genes were found to be more prevalent in MBCs than in UCSs. …”
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    The genetic landscape of metaplastic breast cancers and uterine carcinosarcomas
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