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  1. 2221
    “…TPMs enhance TERT transcription, which is otherwise silenced in adult tissues, thus reactivating a bona fide oncoprotein. To study TERT deregulation and its downstream consequences, we generated a Tert mutant promoter mouse model via CRISPR/Cas9 engineering of the murine equivalent locus (Tert(−123C>T)) and crossed it with thyroid-specific Braf(V600E)-mutant mice. …”
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    Telomerase reactivation induces progression of mouse Braf(V600E)-driven thyroid cancers without telomere lengthening
  2. 2222
    por Napper, Scott, Schatzl, Hermann M.
    Publicado 2023
    “…The immune system does not develop a bona fide immune response against prion infection, as PrP(C) and PrP(Sc) share an identical protein primary structure, and prions seem not to represent a trigger for immune responses. …”
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    Vaccines for prion diseases: a realistic goal?
  3. 2223
    “…Although asbestos carcinogenesis is associated with reactive oxygen species (ROS), the bona fide oncogenic signaling pathways that regulate ROS homeostasis and bypass ROS-evoked apoptosis in MPM are poorly understood. …”
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    MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma
  4. 2224
    “…Overall, we identified bona fide cancer predisposing alterations in five of the investigated 131 (3.8%) patients. …”
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    Resolving inherited and de novo germline predisposing sequence variants by means of whole exome trio analyses in childhood hematological malignancies
  5. 2225
    “…A spontaneous increase in tumorigenic potentials and bona fide HCC histology in xenotransplantations were observed. …”
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    TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
  6. 2226
    “…We identified significantly enriched events at the rrMM stage, including drivers (DUOX2, EZH2, TP53), biallelic inactivation (TP53), noncoding mutations in bona fide drivers (TP53BP1, BLM), copy number aberrations (CNAs; 1qGain, 17pLOH), and double-hit events (Amp1q-ISS3, 1qGain-17p loss-of-heterozygosity). …”
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    Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma
  7. 2227
    “…In vitro, the human trifunctional protein enzyme (hTFP) is a bona fide PtpA substrate, a key enzyme of mitochondrial β-oxidation of long-chain fatty acids, containing two alpha and two beta subunits arranged in a tetramer structure. …”
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    Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism
  8. 2228
    “…In the current study, we identified eukaryotic translation initiation factor 3 subunit H (EIF3H), belonging to the JAB1/MPN/MOV34 (JAMM) superfamily, as a bona fide deubiquitylase of O-GlcNAc transferase (OGT) in HCC. …”
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    The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis
  9. 2229
    “…ErbB3 is one of the bona fide receptors for NRG1. NRG1 and ErbB3 were colocalized with steroidogenic acute regulatory protein (StAR) in normal human ovarian tissue samples, whereas NRG1 and ErBB3 were colocalized with CD105 (Endoglin) and epithelial cadherin (E-cadherin) in human uterine tissue samples. …”
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    FRI394 Anti-inflammatory Protein Neuregulin-1 (NRG1) And ErbB3 Receptor In Human Antral Follicle And Endometrium
  10. 2230
    “…Genome assemblies from 86 bacterial isolates cultured from diseased salmon or lumpfish confirmed them all as bona fide members of the Pasteurellaceae family, with phylogenetic reconstruction dividing them into two distinct branches sharing <88% average nucleotide identity. …”
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    Phylogeography and host specificity of Pasteurellaceae pathogenic to sea-farmed fish in the north-east Atlantic
  11. 2231
    por Pachankis, Y.
    Publicado 2023
    “…Local variants mainly derive from energy source types and energy consumption, however, bona fide data can hardly be retrieved due to deliberate transgressions for certain dire areas. …”
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    Theory on Extremal Nucleon Heuristics to Psychiatry
  12. 2232
    “…Factors affecting TMB calling included sample tumour content, the amount of DNA used in sequencing, and bone fide heterogeneity of node tumour between paired samples. …”
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    Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report
  13. 2233
    “…From these data, we conclude that the Gr-1(+) leukocytes that protect against polymicrobial sepsis are bona fide MDSCs and hypothesize that the mechanism of MDSC-mediated protection includes abrogation of lethal inflammation by IL-10. …”
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    Candida-induced granulocytic myeloid-derived suppressor cells are protective against polymicrobial sepsis
  14. 2234
    “…However, unlike in the mouse, the full-length ABCA17 transcript (4.3 kb) contains numerous mutations that preclude its translation into a bona fide ABC transporter protein strongly suggesting that the human ABCA17 gene is a transcribed pseudogene (ABCA17P). …”
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    The human ortholog of the rodent testis-specific ABC transporter Abca17 is a ubiquitously expressed pseudogene (ABCA17P) and shares a common 5' end with ABCA3
  15. 2235
    “…Finally, we compare the efficacy of our GFP expression effort with EST, OST and SAGE data. CONCLUSION: No bona-fide Hh signaling pathway is present in C. elegans. …”
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    Comprehensive analysis of gene expression patterns of hedgehog-related genes
  16. 2236
    “…The translated sequences have the essential signatures of single domain bona fide globins, or they contain a distinct globin domain that is part of a larger protein. …”
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    Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family
  17. 2237
    “…However, our results also show that each method of RNA amplification detects a unique subset of bona fide neural-enriched transcripts and thus a wider array of authentic neural genes are identified by the combination of these data sets than by the microarray profiles obtained with either method of RNA amplification alone. …”
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    Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system
  18. 2238
    “…Five of these 11 molecules were further shown to be bona fide H/ACA-like molecules. As snoRNA in trypanosomes are organized in clusters, the new H/ACA-like molecules could be used as starting points to manually search for additional molecules in their neighbourhood. …”
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    Psiscan: a computational approach to identify H/ACA-like and AGA-like non-coding RNA in trypanosomatid genomes
  19. 2239
    “…Our validation studies prove that the identified sites are bona fide binding sites for both PPARγ and RXR and that they are functionally capable of driving PPARγ specific transcription. …”
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    De-Novo Identification of PPARγ/RXR Binding Sites and Direct Targets during Adipogenesis
  20. 2240
    “…METHODOLOGY/PRINCIPAL FINDINGS: We have performed a comparative study between HMB-PP and the anti-CD3ε monoclonal antibody OKT3, used as a reference inducer of bona fide TCR signaling, and followed multiple cellular and molecular γδ T-cell activation events. …”
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    Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells
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