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  1. 2281
    “…Taken together, these results indicate that TdIF1 is a bona fide tumor-promoting factor in NSCLC and a potential target for therapy.…”
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    TdIF1: a putative oncogene in NSCLC tumor progression
  2. 2282
    “…Measurements of basal and hotspot recombination in null mutants confirmed that additional, hotspot-enriched proteins are bona fide regulators of hotspot activation within the genome. …”
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    Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot
  3. 2283
    “…Treatment with the non-tumorigenic FGF19-M52 strongly protects Abcb4(−/−) and Fxr(−/−) mice from spontaneous hepatic fibrosis, cellular proliferation and HCC formation in terms of tumor number and size, with significant reduction of biochemical parameters of liver damage and reduced expression of several genes driving the proliferative and inflammatory hepatic scenario. Our data bona fide suggest the therapeutic potential of targeting the FXR-FGF19 axis to reduce hepatic BA synthesis in the control of BA-associated risk of fibrosis and hepatocarcinoma development.…”
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    Suppression of Hepatic Bile Acid Synthesis by a non-tumorigenic FGF19 analogue Protects Mice from Fibrosis and Hepatocarcinogenesis
  4. 2284
    “…Since GABAergic interneurons contact oligodendrocyte precursor cells (OPCs) through bona fide synapses and maintain a close relationship with these progenitors during cortical development, we used this relevant example of neuron-oligodendroglia interaction to implement a proof-of-principle optogenetic approach. …”
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    In vivo Optogenetic Approach to Study Neuron-Oligodendroglia Interactions in Mouse Pups
  5. 2285
    “…Interestingly, the effect of the mutation depended on whether the protein was structured or denatured, indicating that the bona fide tertiary structure of Can f 6 is essential in determining its IgE epitopes.…”
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    Crystal structure of the dog allergen Can f 6 and structure-based implications of its cross-reactivity with the cat allergen Fel d 4
  6. 2286
    por Ohyama, Manabu
    Publicado 2019
    “…SHORT CONCLUSION: Further development of methodologies to reproduce bona fide EMI in HF formation is indispensable. However, human HFSPCs and hiPSCs hold promise as materials for human HF regeneration.…”
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    Use of human intra-tissue stem/progenitor cells and induced pluripotent stem cells for hair follicle regeneration
  7. 2287
    “…This results in our method returning more bona fide regulatory modules than other state-of-the art approaches for clustering on graphs. …”
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    Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis
  8. 2288
    “…In particular, several proteins of the translation initiation complex were identified as bona fide CMA substrates in multiple cancer cell lines of distinct origin and we show that CMA suppresses cellular translation. …”
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    Targetome analysis of chaperone-mediated autophagy in cancer cells
  9. 2289
    “…Although ZEB1 regulates expression of S100 family members, these effects are masked by IL-6/11-STAT3 signalling, and S100 proteins cannot be considered as bona fide EMT markers in PDAC.…”
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    ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins
  10. 2290
    “…The results presented here, significantly reduce the number of bona fide NPF GA transporters in Arabidopsis and narrow the activity to fewer subclades within the family. …”
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    An Optimized Screen Reduces the Number of GA Transporters and Provides Insights Into Nitrate Transporter 1/Peptide Transporter Family Substrate Determinants
  11. 2291
    “…EcLsi1 and EcLsi6 belong to family of NIP2s (Nod26-like major intrinsic protein), bona fide silicon transporters, whereas EcLsi2 and EcLsi3, an efflux Si transporter, belong to an uncharacterized anion transporter family having a significant identity with putative arsB transporter proteins. …”
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    Silicon amendment induces synergistic plant defense mechanism against pink stem borer (Sesamia inferens Walker.) in finger millet (Eleusine coracana Gaertn.)
  12. 2292
    “…In particular, the levels of bona fide memory T cells may be reduced in overweight persons. …”
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    The impact of body mass index on adaptive immune cells in the human bone marrow
  13. 2293
    “…These results strengthen the evidence for obesity as a bona fide risk factor for myeloid leukemias, and in particular APL. …”
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    Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism
  14. 2294
    “…Targeted analysis on bona fide TSGs revealed that H. hathewayi and Streptococcus spp. significantly correlated with CDX2 and MLH1 promoter hypermethylation, respectively. …”
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    Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer
  15. 2295
    “…Our work provides the first characterization of the R. solanacearum catalases and identifies KatE as a bona fide monofunctional catalase with an important role in bacterial protection against oxidative stress.…”
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    KatE From the Bacterial Plant Pathogen Ralstonia solanacearum Is a Monofunctional Catalase Controlled by HrpG That Plays a Major Role in Bacterial Survival to Hydrogen Peroxide
  16. 2296
    “…Additionally, our findings that exercise induces directional muscle clock phase changes confirms that exercise is a bona fide environmental time cue for skeletal muscle.…”
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    Time‐of‐day dependent effects of contractile activity on the phase of the skeletal muscle clock
  17. 2297
    “…Guidelines and funders expect that researchers share IPD for bona fide analyses, but in practice, this is done variably. …”
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    Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine
  18. 2298
    “…To establish whether these alterations are bona fide phenotypic traits of MMP-2 deficiency, we further studied Mmp2(–/–) mice. …”
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    Comparative Serum Analyses Identify Cytokines and Hormones Commonly Dysregulated as Well as Implicated in Promoting Osteolysis in MMP-2-Deficient Mice and Children
  19. 2299
    “…DESIGN, SETTING, AND PARTICIPANTS: We examined 452 bona fide AR target genes in clinical-grade expression profiles from 6532 such CaPs collected between 2013 and 2017 by US physicians ordering the Decipher RP test. …”
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    Diversity in Androgen Receptor Action Among Treatment-naïve Prostate Cancers Is Reflected in Treatment Response Predictions and Molecular Subtypes
  20. 2300
    “…Reactive oxygen species are bona fide intracellular second messengers that influence cell metabolism and aging by mechanisms that are incompletely resolved. …”
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    Stat3 oxidation-dependent regulation of gene expression impacts on developmental processes and involves cooperation with Hif-1α
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