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  1. 2301
    “…Meanwhile, MNT overexpression results in the repression of IκBα, a bona fide REL target. Both MNT and REL bind to the IκBα gene on the first exon, suggesting its regulation as an MNT–REL complex. …”
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    A novel role of MNT as a negative regulator of REL and the NF-κB pathway
  2. 2302
    “…To explore whether peripheral venous blood miRNAs could represent a bona fide specific miRNA deregulation pattern, we selected hypertension, a disease that is particularly associated with vessels, as the model. …”
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    Transcriptome analysis of arterial and venous circulating miRNAs during hypertension
  3. 2303
    “…RESULTS: We found that 7 out of 388 healthy volunteers, who declared no symptoms of Covid-19, like fever, cough, fatigue etc., in the preceding 5 months, have bona fide serum anti-SARS-CoV-2 IgG, that is 1.8% of the asymptomatic population (95% confidence interval: 0.69–2.91%). …”
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    Estimating asymptomatic SARS-CoV-2 infections in a geographic area of low disease incidence
  4. 2304
    “…The reassessment of results from a stream of experiments is of enormous importance in identifying bona fide lead-like candidates to fulfil this quest. This review comprehensively highlights the common pathomechanisms and pharmacological targets of HCoV-OC43, SARS-CoV-1, MERS-CoV and SARS-CoV-2, and potent therapeutic potentials from basic and clinical experimental investigations. …”
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    Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside
  5. 2305
    “…Furthermore, overexpression of an ATG mutant of the full-length transcript reduced network formation, suggesting a bona fide non-coding RNA function of the transcript with opposing effects to SPAAR. …”
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    The LINC00961 transcript and its encoded micropeptide, small regulatory polypeptide of amino acid response, regulate endothelial cell function
  6. 2306
    “…Efforts to predict bona fide TFBSs benefit from the availability of experimental data mapping DNA binding regions of TFs (chromatin immunoprecipitation followed by sequencing - ChIP-seq). …”
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    UniBind: maps of high-confidence direct TF-DNA interactions across nine species
  7. 2307
    “…The structural features of cowpea kinases (VuPKs) indicated that 1,293 bona fide VuPKs covered 20 groups and 118 different families. …”
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    The Cowpea Kinome: Genomic and Transcriptomic Analysis Under Biotic and Abiotic Stresses
  8. 2308
    “…In this study, we present evidence that IncC plasmids encode a bona fide HigB-like toxin that strongly inhibits bacterial growth and results in cell elongation in Escherichia coli. …”
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    The higBA-Type Toxin-Antitoxin System in IncC Plasmids Is a Mobilizable Ciprofloxacin-Inducible System
  9. 2309
    “…We generated specific TA and DN-p73-deficient mouse embryonic stem cell lines using the CRISPR/Cas9 gene editing system and validated them as physiological bona fide p73-isoform knockout models. Global gene expression analysis revealed isoform-specific alterations of distinctive transcriptional networks. …”
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    Deciphering the Nature of Trp73 Isoforms in Mouse Embryonic Stem Cell Models: Generation of Isoform-Specific Deficient Cell Lines Using the CRISPR/Cas9 Gene Editing System
  10. 2310
    “…Compared to similar tools, isoMiRmap is the fastest, reports more bona fide isomiRs, and provides the most comprehensive information related to an isomiR’s transcriptional origin. …”
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    IsoMiRmap: fast, deterministic and exhaustive mining of isomiRs from short RNA-seq datasets
  11. 2311
    “…Moreover, BECN1 acts as a bona fide substrate for ULK1-independent neural autophagy, and ectopic expression of BECN1 somewhat enhances PHEV replication. …”
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    Porcine Hemagglutinating Encephalomyelitis Virus Triggers Neural Autophagy Independently of ULK1
  12. 2312
    “…Our study, using PMCA and animal bioassays, provides the first evidence that CWD PrP(Sc) can cross the species barrier to convert human PrP(C) into infectious PrP(Sc) that can produce bona fide prion disease when inoculated into humanized transgenic mice. …”
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    Generation of human chronic wasting disease in transgenic mice
  13. 2313
    “…Collectively, the data suggest that Smc3 functions as a bona fide tumor suppressor for lymphomas through non-genetic mechanisms, and drives disease by disrupting the commitment of GC B-cells to the plasma cell fate.…”
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    Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes
  14. 2314
    “…CONCLUSIONS: ARBs may aggravate the enteropathy and lead to increased symptoms in patients with bone fide diagnosed CD following a GFD.…”
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    Coeliac disease enteropathy and symptoms may be aggravated by angiotensin receptor blockers in patients on a gluten‐free diet
  15. 2315
    “…Previously, we reported that the plant homeodomain protein ALFIN-LIKE 6 (AL6), a bona fide histone reader that preferentially binds trimethylated lysin 4 on histone 3 (H3K4me3), is critical for recalibration of cellular phosphate (Pi) homeostasis and root hair elongation under Pi-deficient conditions. …”
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    Chromatin enrichment for proteomics in plants (ChEP-P) implicates the histone reader ALFIN-LIKE 6 in jasmonate signalling
  16. 2316
    “…The surface molecular diversity of L‐EVs include (i) bona fide plasma membrane anchored proteins (cluster of differentiation, transporters, receptors and GPI anchored proteins implicated in cell‐cell and cell‐ECM interactions); and (ii) membrane surface‐associated proteins (that are released by divalent ion chelator EDTA) implicated in actin cytoskeleton regulation, junction organization, glycolysis and platelet activation. …”
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    Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform
  17. 2317
    por Lai, Alex L., Freed, Jack H.
    Publicado 2021
    “…Previously, we identified that the domain immediately downstream of the S2’ cleavage site is the bona fide FP (amino acids 798–835) for SARS-1 using ESR spectroscopy technology. …”
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    Critical Negatively Charged Residues Are Important for the Activity of SARS-CoV-1 and SARS-CoV-2 Fusion Peptides
  18. 2318
    “…Together, we propose that aberrantly activated ALK is a bona fide mediator of tau proteinopathy that disrupts autophagosome maturation and causes tau accumulation and aggregation, leading to neuronal dysfunction in AD.…”
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    Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation
  19. 2319
    “…Tom(Low) cells express lower levels of the AT2 differentiation markers Fgfr2b and Etv5, while Tom(High), as bona fide mature AT2 cells, show higher levels of Sftpc, Sftpb, Sftpa1, Fgfr2b and Etv5 expression. …”
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    Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy
  20. 2320
    “…Three prodrugs were identified as bono fide AKR1C3-negative candidates whilst maintaining activity with NfsA_Ec. …”
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    Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications
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