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  1. 221
    “…We have created a toolkit of template-mediated repair cassettes that contain an antibiotic resistance gene to select for worms carrying the repair template and a fluorescent visual marker that facilitates identification of bona fide recombinant animals. Homozygous animals can be identified as early as 4–5 days post-injection, and minimal genotyping by PCR is required. …”
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    Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual-Marker Selection Cassettes
  2. 222
    por Karnkowska, Anna, Hampl, Vladimír
    Publicado 2016
    “…The discovery of such bona fide amitochondriate eukaryote broadens our knowledge about the diversity and plasticity of eukaryotic cells and provides a substantial contribution to our understanding of eukaryotic cell evolution.…”
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    The curious case of vanishing mitochondria
  3. 223
    “…CK2 is highly expressed in the mammalian brain and has many bona fide substrates that are crucial in neuronal or glial homeostasis and signaling processes across synapses. …”
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    CK2—An Emerging Target for Neurological and Psychiatric Disorders
  4. 224
    por Laptenko, Oleg, Prives, Carol
    Publicado 2017
    “…Long understood as a bona fide tumor suppressor that safeguards the integrity of the genome via regulating numerous cellular outcomes, p53 may also exert its decisive and versatile functions by controlling DNA methylation. …”
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    p53: master of life, death, and the epigenome
  5. 225
    “…Twenty years after commercial cultivation of GM crops began, a bona fide report of an adverse health effect due to a commercialized modification in a crop has yet to be reported.…”
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    Characterization of scientific studies usually cited as evidence of adverse effects of GM food/feed
  6. 226
    “…In addition, we tested several of the novel substrates using SUMO immunoprecipitation analysis and confirmed that the SUMO acceptor lysines identified in these proteins are indeed bona fide SUMOylation sites. We believe that the collection of SUMO sites presented here is an important resource for future functional studies of SUMOylation in yeast.…”
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    Identification of SUMO conjugation sites in the budding yeast proteome
  7. 227
    “…There is ongoing debate, however, on the extent to which niche construction ought to be considered a bona fide evolutionary force, on a par with natural selection. …”
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    A variational approach to niche construction
  8. 228
    por Opas, Michal, Fadel, Marc P.
    Publicado 2006
    “…Our data imply that overexpression of calreticulin, while partially reverses fusiform transformed phenotype is in itself insufficient to re-establish bona fide zonulae adherens in transformed fibroblasts.…”
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    Partial reversal of transformed fusiform phenotype by overexpression of calreticulin
  9. 229
    por de Cárcer, Guillermo
    Publicado 2019
    “…Plk1 has strong clinical relevance, as it is considered a bona fide cancer target, it is found overexpressed in a large collection of different cancer types and this tumoral overexpression often correlates with poor patient prognosis. …”
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    The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?
  10. 230
    por Asatryan, Babken
    Publicado 2019
    “…There has been debate about whether left ventricular remodeling is a bona fide phenotypic feature of cardiac sodium channel dysfunction, or a consequence of tachyarrhythmias or conduction disturbances. …”
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    Cardiac Sodium Channel Dysfunction and Dilated Cardiomyopathy: A Contemporary Reappraisal of Pathophysiological Concepts
  11. 231
    “…Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. …”
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    Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity
  12. 232
    por He, Runtao, Li, Xuguang
    Publicado 2008
    “…Compared with the yeast two-hybrid system, the mammalian two-hybrid system provides the milieu for the bona fide posttranslational modifications and localizations of most eukaryotic proteins and, therefore, should be a better choice to study proteins of mammalian origin. …”
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    Mammalian Two-Hybrid Assay for Detecting Protein-Protein Interactions in Vivo
  13. 233
    “…Two back-to-back papers from the Melero’s and Pardo’s groups have now resolved this conundrum, demonstrating that T and NK cell–mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.…”
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    Immunogenicity of cell death driven by immune effectors
  14. 234
    “…Although confirmed as a bona fide complex almost a decade ago, light is just now being shed on the mechanism and selectivity underlying the cellular responsibilities of the EMC. …”
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    Squaring the EMC – how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis
  15. 235
    por Münz, Christian
    Publicado 2021
    “…Epstein Barr virus (EBV) and Kaposi sarcoma associated herpesvirus (KSHV) are two oncogenic human γ-herpesviruses that are each associated with 1-2% of human tumors. They encode bona fide oncogenes that they express during latent infection to amplify their host cells and themselves within these. …”
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    The Role of Lytic Infection for Lymphomagenesis of Human γ-Herpesviruses
  16. 236
    por Danis, Judit, Mellett, Mark
    Publicado 2021
    “…The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. …”
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    Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
  17. 237
    “…Our protocol produces bona fide human ECs with 95%–98% purity by first passage. …”
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    A protocol for transdifferentiation of human cardiac fibroblasts into endothelial cells via activation of innate immunity
  18. 238
    por Fatema, Kaniz, Barrott, Jared J.
    Publicado 2021
    “…We conclude that the study performed by Peng and colleagues was performed with enough rigor to give confidence that circ_0088212 is a bona fide tumor suppressor in osteosarcoma.…”
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    Circling back to epigenetic regulation in osteosarcoma: Comment on ‘Hsa_circ_0088212-mediated miR-520h/APOA1 axis inhibits the osteosarcoma progression’ by ‘ Hao Peng’
  19. 239
    “…In addition, within the past decade, pseudoenzymes of these two families, pseudokinases and pseudophosphatases, have emerged as bona fide signaling regulators. This review discusses the role of pseudophosphatases in MAPK signaling, highlighting the function of phosphoserine/threonine/tyrosine-interacting protein (STYX) and TAK1-binding protein (TAB 1) in regulating MAPKs. …”
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    Pseudophosphatases as Regulators of MAPK Signaling
  20. 240
    “…Significantly, we show that, unlike bona fide ARM, massed conditioning-elicited memory remains sensitive to the amnestic treatment two hours post-training and hence it is not ARM. …”
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    Cold Shock Disrupts Massed Training-Elicited Memory in Drosophila
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