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  1. 2381
    “…SMAD2 was identified as bone fide gene target for miR-3148 using qRT-PCR, Western blotting, and UTR-based reporter assay. …”
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    MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway
  2. 2382
    “…Twenty-eight sRNAs were also detected, including bona fide RsaC. The presence of 22 RNAs within HG003 EVs was confirmed by reverse transcription quantitative PCR (RT-qPCR) experiments. …”
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    Environmental Plasticity of the RNA Content of Staphylococcus aureus Extracellular Vesicles
  3. 2383
    “…RESULTS: In the present study, we identified MINDY1, a DUB enzyme in the motif interacting with ubiquitin-containing novel DUB family, as a bona fide deubiquitylase of YAP in bladder cancer. MINDY1 was shown to interact with, deubiquitylate, and stabilize YAP in a deubiquitylation activity-dependent manner. …”
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    MINDY1 promotes bladder cancer progression by stabilizing YAP
  4. 2384
    por Wu, Tao, Yu, Lihua, Zhang, Yu, Liu, Jin
    Publicado 2021
    “…Functional validation of these CzFADs in yeast and cyanobacterial cells revealed that seven are bona fide FAD enzymes with distinct substrates. Combining the validated functions and predicted subcellular compartments of CzFADs and the FA profiles of C. zofingiensis, the FA desaturation pathways in this alga were reconstructed. …”
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    Characterization of fatty acid desaturases reveals stress-induced synthesis of C18 unsaturated fatty acids enriched in triacylglycerol in the oleaginous alga Chromochloris zofingiensis
  5. 2385
    “…Growing evidence suggests that the ISCT defined phenotype may not represent bona fide osteoprogenitors. Transplantation of both ADSCs and the CD105(-) sub-population of ADSCs has been reported to induce bone regeneration. …”
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    Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection
  6. 2386
    “…CONCLUSIONS: In summary, we present the characteristics and potential use of piRNA-IPdb database for the analysis of bona fide piRNAs.…”
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    piRNA-IPdb: a PIWI-bound piRNAs database to mining NGS sncRNA data and beyond
  7. 2387
    “…Using this polyphasic approach, we characterized the phenotypic and genotypic synapomorphies of Agrobacterium G3, showing it is a bona fide bacterial species, well separated from previously named Agrobacterium species or other recognized genomic species. …”
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    Comparative Genomics of Novel Agrobacterium G3 Strains Isolated From the International Space Station and Description of Agrobacterium tomkonis sp. nov.
  8. 2388
    “…CONCLUSION: DDX5 is a bona fide FL118 direct target and can act as a biomarker for predicting PDAC and CRC tumour sensitivity to FL118. …”
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    FL118, acting as a ‘molecular glue degrader’, binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c‐Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy
  9. 2389
    “…BACKGROUND: Expression of glycoprotein A dominant repeat (GARP) has been reported to occur only in activated human naturally occurring regulatory T cells (Tregs) and their clones, and not in activated effector T cells, indicating that GARP is a marker for bona fide Tregs. A different phenotype of chronic obstructive pulmonary disease (COPD) may have a different immunologic mechanism. …”
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    Reduced frequencies of Foxp3(+)GARP(+) regulatory T cells in COPD patients are associated with multi-organ loss of tissue phenotype
  10. 2390
    “…The expression of the tumour suppressor RASSF1A, a bona fide activator of the MST2 pathway, is silenced by promoter methylation in over half of melanomas and correlates with poor prognosis. …”
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    Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner
  11. 2391
    “…We found that IMI exposure in wild-type (WT) mice induced hepatic expression of Cyp2b10, a bona fide target of CAR. This data led us to investigate the role of CAR in alleviating IMI toxicity. …”
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    RF03 | PMON287 Examining the role of Constitutive Androstane Receptor during Imidacloprid exposure
  12. 2392
    “…We confirmed that RopB is the bona fide amyloid protein since its fibrils exhibit circular x-ray reflections indicating its cross-β structure specific for amyloids. …”
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    RopB protein of Rhizobium leguminosarum bv. viciae adopts amyloid state during symbiotic interactions with pea (Pisum sativum L.)
  13. 2393
    “…Furthermore, six bona fide proximal epithelioid sarcoma (PES), fourteen atypical teratoid/rhabdoid tumors (ATRT) in brain and five pediatric poorly differentiated chordomas (PDC) in the clivus were collected for comparative analysis of differential diagnostic maker expression and DNA methylation profile. …”
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    Primary adult sellar SMARCB1/INI1-deficient tumor represents a subtype of atypical teratoid/rhabdoid tumor
  14. 2394
    “…CONCLUSION: Caution in interpreting these estimates as bona fide prevalence rates is warranted. Critical appraisal of the obtained prevalence rates and triangulation with other sources are recommended over “the higher rate must be closer to the truth” heuristics. …”
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    Hidden figures: Revisiting doping prevalence estimates previously reported for two major international sport events in the context of further empirical evidence and the extant literature
  15. 2395
    “…Our analysis disclosed the existence of different bona fide pairs of recombinationally-active pXerC/D sites in these plasmids, some mediating reversible intramolecular inversions and others reversible plasmid fusions/resolutions. …”
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    Dynamic state of plasmid genomic architectures resulting from XerC/D-mediated site-specific recombination in Acinetobacter baumannii Rep_3 superfamily resistance plasmids carrying bla(OXA-58)- and TnaphA6-resistance modules
  16. 2396
    Publicado 1990
    Tabla de Contenidos: “…Da laudis, homo, nova cantica : conductus (3:43) -- Annus novus in gaudio : versus (4:27) -- Rex Salomon fecit templum : versus/sequenz (6:53) -- Letamini plebs hodie fidelis : benedicamus-tropus (2:49) -- Natali regis glorie : conductus (3:07) -- Stirps Jesse florigeram : benedicamus-tropus (2:25) -- Iubilemus, exultemus : benedicamus -tropus (3:18) -- Letabundi iubilemus : benedicamus-tropus (3:14) -- Ex Ade vitio : conductus (6:11) -- Noster cetus : benedicamus-tropus (3:52) -- Natus est : conductus (2:43) -- Dulcis sapor novi mellis : benedicamus-tropus (5:16) -- Alto consilio : conductus (5:34)…”
    CD Audiom
    Nova cantica Latin songs of the high Middle Ages.
  17. 2397
    por Sousa, John Philip, 1854-1932
    Publicado 1998
    Tabla de Contenidos: “…Red man (3:16) ; White man (8:00) ; Black man (3:28) -- March: The invincible eagle (3:22) -- Humoresque on Gershwin's "Swanee" (5:34) -- Semper fidelis (1:58) -- Humoresque on Kern's Look for the silver lining (5:35) -- March : The daughters of Texas (3:05) -- March : The stars and stripes forever (3:21).…”
    CD Audiom
    John Philip Sousa.
  18. 2398
    “…Any such support package should include support for agri-SMEs to develop sustainable marketing strategies and help them secure flexible financing that considers payment deferrals and debt moratorium during bona fide market shocks such as the COVID-19 pandemic.…”
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    African agri-entrepreneurship in the face of the COVID-19 pandemic
  19. 2399
    “…RESULTS: In the present study, we identified ATXN3, a DUB enzyme in the ubiquitin-specific proteases family, as a bona fide deubiquitylase of YAP in PC. ATXN3 was shown to interact with, deubiquitylate, and stabilize YAP in a deubiquitylation activity-dependent manner. …”
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    ATXN3 promotes prostate cancer progression by stabilizing YAP
  20. 2400
    “…It acts due to association with Xic1 serving as a bona fide CDK1 inhibitor upstream of Aurora A and Polo-Like Kinase 1 (PLK1), both of which are CDK1 activators. …”
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    CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression
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