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301por Liu, Donghui, Rychkov, Grigori, Hurtado, Plinio, Luo, Hai-Yun, Zhang, Tao, Bobrovskaya, Larisa, Zhou, Xin-Fu“…Furthermore, our results demonstrate that these human iNSCs (hiNSCs) have similar gene expression profiles to bona fide NSCs, can proliferate, and are capable of differentiating into glial cells and functional neurons. …”
Publicado 2022
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302por Seetharam, Arun S., Vu, Ha T.H., Choi, Sehee, Khan, Teka, Sheridan, Megan A., Ezashi, Toshihiko, Roberts, R. Michael, Tuteja, Geetu“…Here, by analyzing transcriptome data from multiple sources, including bulk and single-cell data, we show that the BMP4 procedure generates bona fide TB with similarities to both placental villous TB and TB generated from TB stem cells. …”
Publicado 2022
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303“…As a proof-of-concept demonstration, we validated acetylated PDIA1 protein as a bona fide binding partner of BRD1. Our work suggests that BRD1 interacts with additional acetyllysine motifs, beyond those characterized in histone proteins.…”
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304“…As a bona fide epigenetic marker, DNA methylation has been linked to the differentiation and function of regulatory T (Treg) cells, a subset of CD4 T cells that play an essential role in maintaining immune homeostasis and suppressing autoimmunity and antitumor immune response. …”
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305por Behrmann, Sarah Christin, Witczak, Natasha, Lang, Christian, Schieler, Manuela, Dettweiler, Anna, Kleinhenz, Benno, Schwind, Mareike, Vilcinskas, Andreas, Lee, Kwang-Zin“…We developed a state-of-the-art qRT-PCR protocol using TaqMan probes to study the prevalence of two bona fide SBR pathogens: Candidatus Arsenophonus phytopathogenicus (Gammaproteobacteria) and Candidatus Phytoplasma solani (stolbur phytoplasma). …”
Publicado 2022
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306por Tortora, Davide, Roberts, Morgan E., Kumar, Gunjan, Kotapalli, Sudha S., Ritch, Elie, Scurll, Joshua M., McConeghy, Brian, Sinha, Sunita, Wyatt, Alexander W., Black, Peter C., Daugaard, Mads“…Here, we developed an endogenous PPARG reporter system in luminal bladder cancer cells and performed genome-wide CRISPR knockout screening to identify bona fide regulators of PPARG gene expression. Functional validation of the dataset confirmed GATA3, SPT6, and the cohesin complex components SMC1A, and RAD21, as permissive upstream positive regulators of PPARG gene expression in luminal bladder cancer. …”
Publicado 2023
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307por Tang, Yu, Qian, Cheng, Zhou, Yueke, Yu, Chang, Song, Mengyao, Zhang, Teng, Min, Xuewen, Wang, Aiyun, Zhao, Yang, Lu, Yin“…Platelets have been widely recognized as a bona fide mediator of malignant diseases, and they play significant roles in influencing various aspects of tumor progression. …”
Publicado 2023
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308“…The data obtained indicate that this strategy leads to bona fide tripartite fusion proteins and that the EGFP tag did not affect the subcellular localization of such proteins. …”
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309“…Proteins in these two families bind tightly to the cell wall and their activity is typically assayed by their stimulation of cell-wall extension and stress relaxation; no bona fide enzymatic activity has been detected for these proteins. α-Expansin proteins and some, but not all, β-expansin proteins are implicated as catalysts of 'acid growth', the enlargement of plant cells stimulated by low extracellular pH. …”
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310“…Although several proteome-scale analyzes have been performed to delineate potential sumoylatable proteins, the bona fide sumoylation sites still remain to be identified. …”
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311por Sapoznikov, Anita, Fischer, Jens A.A., Zaft, Tami, Krauthgamer, Rita, Dzionek, Andrzej, Jung, Steffen“…Our results establish PDCs as a bona fide DC subset that initiates unique CD4(+) Th cell–dominated primary immune responses.…”
Publicado 2007
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312por Bouquet, Jean-Marie, Spriet, Endy, Troedsson, Christofer, Otterå, Helen, Chourrout, Daniel, Thompson, Eric M.“…Among the short list of bona fide biological model organisms, all share the property that they are amenable to long-term maintenance in laboratory cultures. …”
Publicado 2009
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313“…Transcranial magnetic stimulation (TMS) has quickly progressed from a technical curiosity to a bona-fide tool for neurological research. The impetus has been due to the promising results obtained when using TMS to uncover neural processes in normal human subjects, as well as in the treatment of intractable neurological conditions, such as stroke, chronic depression and epilepsy. …”
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314“…OBJECTIVE: In order to compare their validity, this review applies scientific standards for sustaining the neuroses, the schizophrenias and bipolar disorders as separate “bona-fide” psychiatric diseases. The standards for disease validation demand specific and unique symptoms. …”
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315“…Zebrafish (Danio rerio) is a bona fide vertebrate model system for understanding human diseases. …”
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316“…Here, we show that the major protein components of this pathway, the CCBs, are bona fide transmembrane proteins. We demonstrate their association in a series of hetero-oligomeric complexes, some of which interact transiently with cytochrome b(6) in the process of heme delivery to the apoprotein. …”
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317por Vaccino, Patrizia, Becker, Heinz-Albert, Brandolini, Andrea, Salamini, Francesco, Kilian, Benjamin“…In the present paper, we have adopted a genomic approach in order to understand the potential CD danger represented by storage proteins in diploid wheat and sequenced a sufficiently large number of cDNA clones related to storage protein genes of Triticum monococcum. Four bona fide toxic peptides and 13 immunogenic peptides were found. …”
Publicado 2008
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318por Espinosa, Maria Claudia, Rehman, Muhammad Attiq, Chisamore-Robert, Patricia, Jeffery, Daniel, Yankulov, Krassimir“…Here we show that the deletion of GCN5 decreases the stability of mini-chromosomes; that the tethering of Gcn5p to a crippled origin of replication stimulates its activity; that high dosage of GCN5 suppresses conditional phenotypes caused by mutant alleles of bona fide replication factors, orc2-1, orc5-1 and mcm5-461. …”
Publicado 2010
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319“…Several marks transitioned near bona fide exons, but not near nucleosomes at exon-like sequences. …”
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320por Knöll, Bernd“…SRF teams up with myocardin related transcription factors (MRTFs) and ternary complex factors (TCFs) to mediate cellular actin cytoskeletal dynamics and the immediate-early gene (IEG) response, a bona fide indicator of neuronal activation. Herein, I will discuss how SRF and cofactors might modulate physiological processes of neuronal motility. …”
Publicado 2011
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