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321“…Unfortunately, the availability of well-characterized promoters that direct bona-fide expression of transgenes in transgenic mice is limited. …”
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322por Harach, Taoufiq, Pols, Thijs W. H., Nomura, Mitsunori, Maida, Adriano, Watanabe, Mitsuhiro, Auwerx, Johan, Schoonjans, Kristina“…Anionic exchange resins are bona fide cholesterol-lowering agents with glycemia lowering actions in diabetic patients. …”
Publicado 2012
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323por Newman, Alice C., Scholefield, Caroline L., Kemp, Alain J., Newman, Michelle, McIver, Edward G., Kamal, Ahmad, Wilkinson, Simon“…Furthermore, basal autophagy in this context is characterised by sequestration of the xenophagy cargo receptor Ndp52 and its paralogue Tax1bp1, which we demonstrate here to be a bona fide cargo receptor. Autophagy of these cargo receptors promotes non-canonical NF-κB signalling. …”
Publicado 2012
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324“…Many of these proteins, in addition to their bona fide roles in DNA replication are also required for other cell cycle events including heterochromatin organization, chromosome segregation and centrosome biology. …”
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325por Guo, Qian, Koirala, Sajjan, Perkins, Edward M., McCaffery, J. Michael, Shaw, Janet M.“…In this study, we demonstrate that Caf4 is a bona fide fission adaptor that assembles at sites of mitochondrial division. …”
Publicado 2012
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326por Teh, Phildrich G., Chen, Mark J., Engel, James L., Worby, Carolyn A., Manning, Gerard, Dixon, Jack E., Zhang, Ji“…Moreover, its expression restored cardiolipin deficiency and reversed growth impairment in a Saccharomyces cerevisiae mutant lacking the yeast PGP phosphatase, suggesting that it is a bona fide PTPMT1 ortholog. When ectopically expressed, this bacterial PGP phosphatase was localized in the mitochondria of yeast and mammalian cells. …”
Publicado 2013
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327por Matsuki, Takahiro, Pédron, Thierry, Regnault, Béatrice, Mulet, Céline, Hara, Taeko, Sansonetti, Philippe J.“…In an attempt to identify and characterize how symbiotic bacteria of the gut microbiota affect the molecular and cellular mechanisms of epithelial homeostasis, intestinal epithelial cells were co-cultured with either Lactobacillus or Bifidobacterium as bona fide symbionts to examine potential gene modulations. …”
Publicado 2013
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328por Lee, Wen-Chung“…Using the new PRISM criterion, many situations in which there is not evidence of interaction judged by the traditional indices are in fact corresponding to bona fide positive or negative synergisms.…”
Publicado 2013
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329“…Not surprisingly, bona fide intracellular pathogens developed strategies for manipulation of cell death to guarantee intracellular replication. …”
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330“…The Rb1 gene was the first bona fide tumor suppressor identified and cloned more than 25 years ago. …”
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331“…Because it contains various immune cells, either adaptive (B and T lymphocytes; such as regulatory T cells) or innate (mostly macrophages and, more recently identified, myeloid-derived suppressor cells), the adipose tissue is now considered as a bona fide immune organ, at the cross-road between metabolism and immunity. …”
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332por Feuermann, Yonatan, Kang, Keunsoo, Shamay, Avi, Robinson, Gertraud W., Hennighausen, Lothar“…The miR-21 promoter sequence contains a bona-fide STAT5 binding site and miR-21 levels increased in HC11 mammary cells upon prolactin treatment. …”
Publicado 2014
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333“…We will demonstrate that the TP schema is a bona fide rule-based code, conforming to logical code-like properties. …”
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334“…The data strongly suggests that these elements, designated ‘casposons’, are likely to be bona fide DNA transposons and that their Cas1 nucleases act as transposases and are possibly still active.…”
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335“…We also suggest that our refined database of “bona fide” lncRNAs will be valuable for the discovery of other sequence characteristics distinct to lncRNAs.…”
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336“…The majority of these mutations lead to a loss of expression of the ARID1A protein, which is a subunit of the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex and considered as a bona fide tumor suppressor. Upregulation of the PIK3/AKT/mTOR pathway, particularly through mutations of PIK3CA and inactivation of PTEN, is involved in tumorigenesis of CCC. …”
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337por Yuan, Lin, Chen, Zhongbin, Song, Shanshan, Wang, Shan, Tian, Chunyan, Xing, Guichun, Chen, Xiaojuan, Xiao, Zhi-Xiong, He, Fuchu, Zhang, Lingqiang“…Meanwhile, we identify IRF7 (interferon regulatory factor 7) as a bona fide target gene of p53 to mediate the p53-directed production of type I interferon and the innate immune response. …”
Publicado 2015
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338“…We confirm that several of the proteins identified are bona fide in vitro FAK substrates, including several factors which are known to regulate the NFκB pathway. …”
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339por Tovar-Herrera, Omar Eduardo, Batista-García, Ramón Alberto, Sánchez-Carbente, María del Rayo, Iracheta-Cárdenas, María Magdalena, Arévalo-Niño, Katiushka, Folch-Mallol, Jorge Luis“…To the best of our knowledge, this is the first report of a bona fide fungal expansin found in a basidiomycete and we could express the bioactive protein in Pichia pastoris.…”
Publicado 2015
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340por Pacheco, Mírian L. A. Forancelli, Galante, Douglas, Rodrigues, Fabio, de M. Leme, Juliana, Bidola, Pidassa, Hagadorn, Whitey, Stockmar, Marco, Herzen, Julia, Rudnitzki, Isaac D., Pfeiffer, Franz, Marques, Antonio C.“…The Ediacaran fossil Corumbella is important because it is hypothesized to be a scyphozoan cnidarian, and thus might be one of the rare examples of bona fide Neoproterozoic animals. Unfortunately, its mode of life, style of skeletonization, and taxonomic affinity have been very controversial. …”
Publicado 2015
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