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  1. 341
    “…Our results provide strong support for hypotheses in which the eukaryotic host evolved from a bona fide archaeon, and demonstrate that many components that underpin eukaryote-specific features were already present in that ancestor. …”
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    Complex archaea that bridge the gap between prokaryotes and eukaryotes
  2. 342
    “…Results: We found only 11/31 actual wound infections, the remainder were not bona fide wound infections, but were colonized seromas. …”
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    Post-Laminectomy Wound Infections: Colonized Seromas Mimicking Wound Infections
  3. 343
    por Klinge, Carolyn M.
    Publicado 2015
    “…This review focuses primary on the regulation of miRNA expression by ligand-activated ERs and their bona fide gene targets and includes miRNAs regulation by tamoxifen and endocrine disrupting chemicals (EDCs) in breast cancer and cell lines.…”
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    miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets
  4. 344
    “…We developed a computational method that compares postmortem damage patterns of a test dataset with bona fide ancient and modern DNA. We applied this test to the putative wheat DNA and find that these reads are most likely not of ancient origin. …”
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    Contesting the presence of wheat in the British Isles 8,000 years ago by assessing ancient DNA authenticity from low-coverage data
  5. 345
    “…These cells contain melanosomes of all four stages of development and they depend on Microphthalmia associated transcription factor (MITF), the master regulator of melanocyte development, suggesting that they are bona-fide melanocytes. The location of these pigmented cells is consistent with the location of meningeal melanomas in humans and animal models. …”
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    Meningeal Melanocytes in the Mouse: Distribution and Dependence on Mitf
  6. 346
    “…Our results are consistent with ZNF451 functioning as a bona fide SUMO E3 ligase.…”
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    Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase
  7. 347
    “…Although CCR7 defines bona fide Rag2GFP(+) Treg precursors, it is not required for Treg production and emigration. …”
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    CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells
  8. 348
    “…These findings establish the concept of oncometabolic nuclear reprogramming of stemness as a bona fide metabolo-epigenetic mechanism for generation of cancer stem-like cells.…”
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    Oncometabolic Nuclear Reprogramming of Cancer Stemness
  9. 349
    por Aird, Katherine M, Zhang, Rugang
    Publicado 2014
    “…OIS is therefore considered a bona fide tumor suppression mechanism in vivo. Indeed, overcoming OIS-associated stable cell growth arrest can lead to tumorigenesis. …”
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    Metabolic alterations accompanying oncogene-induced senescence
  10. 350
    “…Because it is only slightly younger than the oldest recorded Ginkgo reproductive organs (the Yima Formation, 170 Myr), this fossil wood very probably represents the oldest bona fide fossil Ginkgo wood and the missing ancestral form of Ginkgo wood evolution.…”
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    A Jurassic wood providing insights into the earliest step in Ginkgo wood evolution
  11. 351
    “…Here we report that crenactin forms bona fide double helical filaments that show exceptional similarity to eukaryotic F-actin. …”
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    Crenactin forms actin-like double helical filaments regulated by arcadin-2
  12. 352
    por Shrestha, Amit, Megeney, Lynn A.
    Publicado 2015
    “…Moreover, we discuss the intriguing concept that yeast specific proteins may be utilized as bona fide therapeutic agents, to correct proteostasis errors across various forms of neurodegeneration.…”
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    Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration
  13. 353
    “…We found that SEZ-derived oligodendroglial progenitors have limited self-renewing potential and are therefore not bona fide OPCs but rather “oligodendroblasts” more similar to the neuroblasts of the neurogenic output of the SEZ. …”
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    Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice
  14. 354
    “…However, it is still unclear which proteasome subunit(s) are the bona fide substrate(s) of UBLCP1 and the precise mechanism for proteasome regulation remains elusive. …”
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    Phosphatase UBLCP1 controls proteasome assembly
  15. 355
    “…We found early cystic lesions in a secondary organ (liver) that lacked the expression of bona fide lung makers namely Scgb1a1 and surfactant protein C Sftpc and were DsRed positive hence identifying lung as their source of origin. …”
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    Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer
  16. 356
    “…We demonstrate that dermal Schwann cells do not belong to the Myf5(+) cell lineage, indicating that previous tracing data reflected aberrant cre recombinase expression and that bona fide Myf5(+) dermal precursors cannot transdifferentiate to neural lineages in physiological conditions.…”
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    Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors
  17. 357
    “…Based on the enzymatic activities of the recombinant proteins, both of these genes encoded bona fide 4CLs. The 4CL isoforms in S. moellendorffii have different activities: Sm4CL2 was more active than Sm4CL1. …”
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    Cloning and Functional Characterization of Two 4-Coumarate: CoA Ligase Genes from Selaginella moellendorffii
  18. 358
    “…Both of the isoforms of LXRs and their bona fide ligands are present in the ovary. LXR-deficient mice develop late sterility due to abnormal oocyte maturation and increased oocyte atresia. …”
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    Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility
  19. 359
    por Jean, Didier, Jaurand, Marie-Claude
    Publicado 2018
    “…Other genes and pathways appear as bona fide modulators of the neoplastic transformation.…”
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    Mesotheliomas in Genetically Engineered Mice Unravel Mechanism of Mesothelial Carcinogenesis
  20. 360
    “…Despite their importance, few bona-fide MA channels have been described in plants and animals. …”
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    OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
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