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Mostrando 441 - 460 Resultados de 2,933 Para Buscar '"FIDE"', tiempo de consulta: 0.37s Limitar resultados
  1. 441
    “…A recent study has analyzed the link between BBH and orthology in bacteria and archaea and concluded that, given the very high consistency in BBH they observed among triplets of neighboring genes, a high proportion of BBH are likely to be bona fide orthologs. However, limited by their analysis setup, the previous study could not easily test the reverse question: which proportion of orthologs are BBH? …”
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    Bidirectional Best Hits Miss Many Orthologs in Duplication-Rich Clades such as Plants and Animals
  2. 442
    “…We demonstrate that TgPPT1 is a bona fide depalmitoylase, thereby establishing an important role for dynamic and reversible palmitoylation in host-cell invasion by T. gondii.…”
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    Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion
  3. 443
    por Sun, Kun, Zhao, Yu, Wang, Huating, Sun, Hao
    Publicado 2014
    “…Hence, we implemented sebnif, an integrative bioinformatics pipeline to facilitate the discovery of bona fide novel lincRNAs that are suitable for further functional characterization. …”
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    Sebnif: An Integrated Bioinformatics Pipeline for the Identification of Novel Large Intergenic Noncoding RNAs (lincRNAs) - Application in Human Skeletal Muscle Cells
  4. 444
    “…Tip60 is a lysine acetyltransferase that acetylates histones and other proteins to regulate gene expression, DNA damage response, apoptosis and cell cycle regulation. Tip60 is a bona fide tumor suppressor since mice that are haploid for Tip60 are predisposed to tumors. …”
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    Tip60 Degradation by Adenovirus Relieves Transcriptional Repression of Viral Transcriptional Activator EIA
  5. 445
    “…To determine whether BLK is indeed a bona fide susceptibility gene, we developed an experimental mouse model, namely the Blk(+/−).lpr/lpr (Blk(+/−).lpr) mouse, in which Blk expression levels are reduced to levels comparable to those in individuals carrying a risk allele. …”
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    Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice
  6. 446
    por Hurowitz, Evan H, Brown, Patrick O
    Publicado 2004
    “…Analysis of genes deviating from that relationship identified ORFs with annotation errors, ORFs that appear not to be bona fide genes, and potentially novel genes. Interestingly, we found that systematic differences in the total length of the untranslated sequences in mRNAs were related to the functions of the encoded proteins. …”
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    Genome-wide analysis of mRNA lengths in Saccharomyces cerevisiae
  7. 447
    “…PHLPP2 is progressively lost in glioma and colorectal cancer and acts as a bona fide tumor suppressor, depending on IKKβ expression in cells. …”
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    PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase
  8. 448
    “…Thus, nonneural crest-derived mesenchymal precursors can differentiate into bona fide peripheral glia in the absence of genetic manipulation, suggesting that developmentally defined lineage boundaries are more flexible than widely thought.…”
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    Direct Genesis of Functional Rodent and Human Schwann Cells from Skin Mesenchymal Precursors
  9. 449
    “…Since each conformation of COMT is a bona fide target for inhibitors, other states than the closed conformation may be promising to address. …”
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    Mapping the conformational space accessible to catechol-O-methyltransferase
  10. 450
    “…The elution and sequencing of peptides by mass spectrometric analysis enable determining the bona fide repertoire of presented peptides for a given allele. …”
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    Soluble HLA Technology as a Strategy to Evaluate the Impact of HLA Mismatches
  11. 451
    “…We also present hypotheses that ANP32C and other intronless sequences should not currently be considered bona fide family members, that their disparate necessity in development may be due to compensatory mechanisms, that their contrasting roles in cancer are likely context-dependent, along with an underlying hypothesis that ANP32s represent an important node of physiological regulation by virtue of their diverse biochemical activities.…”
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    Cracking the ANP32 whips: Important functions, unequal requirement, and hints at disease implications
  12. 452
    “…We also identified translocations between bona fide nuclease targets on homologous chromosomes, an undesired collateral effect that has not been described. …”
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    Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
  13. 453
    “…Here, we discuss current combinatorial approaches to convert otherwise non-immunogenic instances of RCD into bona fide ICD.…”
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    Combinatorial Strategies for the Induction of Immunogenic Cell Death
  14. 454
    “…In this paper we model a helix as a series of different but all bona fide helical curves; each one best fits the coordinates of four consecutive backbone C(α) atoms for a protein or P atoms for a DNA molecule. …”
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    An Accurate Model for Biomolecular Helices and Its Application to Helix Visualization
  15. 455
    por Cao, Chen, Xu, Shutan, Wang, Lincong
    Publicado 2015
    “…The first step searches for a series of bona fide helical curves each one best fits the coordinates of four successive backbone C(α) atoms. …”
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    An Algorithm for Protein Helix Assignment Using Helix Geometry
  16. 456
    “…Although the majority of specimens emerged from sores or breaks in the skin, there was concern that they did not represent bona fide cases of Dracunculus medinensis and that they needed detailed examination and identification as provided by the World Health Organization Collaborating Center (WHO CC) at Centers for Disease Control and Prevention (CDC). …”
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    Thirty-Seven Human Cases of Sparganosis from Ethiopia and South Sudan Caused by Spirometra Spp.
  17. 457
    “…By virtue of functional cooperation between HCK and bona fide oncogenic tyrosine kinases, excessive HCK activation can also reduce drug efficacy and contribute to chemo-resistance, while genetic ablation of HCK results in minimal physiological consequences in healthy mice. …”
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    Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells
  18. 458
    “…Together, these findings conclusively delineate a source of bona-fide endogenous human muscle stem cells that will aid development of clinical applications.…”
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    Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles
  19. 459
    “…Glioblastoma (GBM) is the most lethal brain cancer with profound genomic alterations. While the bona fide tumor suppressor genes such as PTEN, NF1, and TP53 have high frequency of inactivating mutations, there may be the genes with GBM-suppressive roles for which genomic mutation is not a primary cause for inactivation. …”
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    In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma
  20. 460
    “…Unlike oomycetes, fungal effectors do not share conserved motifs and candidate prediction relies on a set of a priori criteria established from reported bona fide effectors. Secretome prediction, genome-wide analysis of gene families and transcriptomics of M. larici-populina have led to catalogs of more than a thousand secreted proteins. …”
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    Effector-Mining in the Poplar Rust Fungus Melampsora larici-populina Secretome
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