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  1. 641
    “…We have identified mutation of ileS to be one of the bona fide genetic events leading to the acquisition of vancomycin tolerance in S. aureus, potentially acting via inhibition of the function of IleRS.…”
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    In Vitro Tolerance of Drug-Naive Staphylococcus aureus Strain FDA209P to Vancomycin
  2. 642
    “…Metabolic (15)N-labeling thereby enabled stringent discrimination between bona fide interaction partners and nonspecifically captured proteins. …”
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    Proteomic Analysis of the Mediator Complex Interactome in Saccharomyces cerevisiae
  3. 643
    “…In vitro MGE-like cells resembled bona fide MGE cells but expressed lower levels of Foxg1 and Epha4. …”
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    Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types
  4. 644
    “…Hydrocarbon-stapled peptides that display key residues of the p53 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX. …”
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    Mechanistic Validation of a Clinical Lead Stapled Peptide that Reactivates p53 by Dual HDM2 and HDMX Targeting
  5. 645
    “…Single amino acid substitutions in P38 could dissociate dsRNA-processing from AGO-loading inhibition in vitro and in vivo, illustrating dual-inhibitory strategies discriminatively deployed within a single viral protein, which, we further show, are bona fide suppressor functions that evolved independently of the conserved coat protein function of P38.…”
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    Biochemical and genetic functional dissection of the P38 viral suppressor of RNA silencing
  6. 646
    “…The EPIYA motif, upon phosphorylation by host kinases, binds and deregulates Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2), a bona fide oncoprotein, inducing pro-oncogenic mitogenic signaling and abnormal cell morphology. …”
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    Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein
  7. 647
    “…These results indicate the importance of assessing miR function in the complex physiology of in vivo model systems and indicate that further functional testing of miR-342 is required before concluding it is a bona fide tumor-suppressor-miR.…”
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    No Functional Role for microRNA-342 in a Mouse Model of Pancreatic Acinar Carcinoma
  8. 648
    “…To address the proverbial "elephant in the room" as to whether MTH1 is a bona fide chemotherapeutic target, we provide an overview of MTH1 function in the context of tumor biology, summarize the current literature on MTH1 inhibitors, and discuss the molecular contexts likely required for its efficacy as a therapeutic target.…”
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    MTH1 as a Chemotherapeutic Target: The Elephant in the Room
  9. 649
    “…We conclude that large COPII vesicles are bona fide carriers of PC1.…”
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    COPII-coated membranes function as transport carriers of intracellular procollagen I
  10. 650
    por Kiefer, Florian W
    Publicado 2017
    “…Two distinct strategies are currently being pursued; one is the activation of bone fide BAT, the other is the induction of BAT-like cells or beige adipocytes within white fat depots, a process called browning. …”
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    The significance of beige and brown fat in humans
  11. 651
    “…PTs significantly more frequently displayed mutations affecting MED12, the TERT gene promoter and bona fide cancer genes, whereas adenosarcomas harbored a higher rate of MDM2/CDK4 and TERT gene amplifications. …”
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    Genetic analysis of uterine adenosarcomas and phyllodes tumors of the breast
  12. 652
    “…We demonstrate that blocking cardiomyocyte production of GDF15 normalizes circulating GDF15 level and restores liver GH signaling, establishing GDF15 as a bona fide heart‐derived hormone that regulates pediatric body growth. …”
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    GDF15 is a heart‐derived hormone that regulates body growth
  13. 653
    “…The data presented here demonstrate that tRFs are bona-fide regulatory microRNA-like small RNAs involved in the regulation of genome stability through the targeting of TE transcripts.…”
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    tRNA-derived small RNAs target transposable element transcripts
  14. 654
    “…Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is known about its role in ACS. …”
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    Decreased Helios Expression in Regulatory T Cells in Acute Coronary Syndrome
  15. 655
    “…This allowed for dissecting bona fide caveolar functions from those supported by mere caveolin presence and also demonstrated that neither caveolin3 nor caveolin3 and cavin1 are sufficient to form caveolae. …”
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    Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination
  16. 656
    “…We find that T3 phosphorylation is greatly reduced in samples from Huntington’s disease models and in Huntington’s disease patients, and we provide evidence that bona-fide T3 phosphorylation alters Huntingtin exon 1 protein conformation and aggregation properties. …”
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    Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
  17. 657
    “…Genomic and genetic approaches implicate Atf3 as a regulator of cytoskeleton organization and function, and identify Lamin C as one of its bona fide target genes. By affecting structural features and cell morphology, Atf3 functions in a manner distinct from other transcription factors operating downstream of disrupted cell polarity.…”
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    Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture
  18. 658
    “…Analysis of HSC development in model organisms has identified some of the molecular cues that are necessary to instruct hematopoiesis in vivo, including Wnt9A, which is required during an early time window in zebrafish development. Although bona fide HSCs cannot be derived in vitro, it is possible to model human hematopoietic progenitor development by differentiating human pluripotent stem cells to hematopoietic cells. …”
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    WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development
  19. 659
    “…These results provide the first genetic evidence that reck is a bona fide tumor suppressor gene for MPNSTs in zebrafish. …”
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    Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors
  20. 660
    “…Here, we analyzed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification and differentiation. …”
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    A PAX5-OCT4-PRDM1 Developmental Switch Specifies Human Primordial Germ Cells
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