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661“…Glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are bona fide self-renewal factors for spermatogonial stem cells (SSCs). …”
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662“…Hydrogen sulfide (H(2)S) has emerged as a relevant signaling molecule in physiology, taking its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO). …”
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663por Torres-Cifuentes, Diana M., Galindo-Rosales, José M., Saucedo-Cárdenas, Odila, Valdés, Jesús“…Altogether our data suggest that EhSyf is a bona fide Syf1 ortholog involved in transcription and splicing.…”
Publicado 2018
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664por Ausiannikava, Darya, Mitchell, Laura, Marriott, Hannah, Smith, Victoria, Hawkins, Michelle, Makarova, Kira S, Koonin, Eugene V, Nieduszynski, Conrad A, Allers, Thorsten“…The newly generated elements are bona fide chromosomes, because each bears “chromosomal” replication origins, rRNA loci, and essential genes. …”
Publicado 2018
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665“…The homologue of tal in the flour beetle Tribolium castaneum (called milles-pattes, mlpt) is a bona fide gap gene. We find that Ca-tal is expressed in the region previously reported as lacking gap gene expression. …”
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666por Hiramoto, Emiri, Tsutsumi, Akihisa, Suzuki, Risa, Matsuoka, Shigeru, Arai, Satoko, Kikkawa, Masahide, Miyazaki, Toru“…The discovery of the bona fide shape of the IgM pentamer advances our structural understanding of the pentameric IgM and its binding mode with AIM.…”
Publicado 2018
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667por Nishimura, Tamiko, Fakim, Hana, Brandmann, Tobias, Youn, Ji-Young, Gingras, Anne-Claude, Jinek, Martin, Fabian, Marc R“…Importantly, we provide a 1.7 Å resolution crystal structure of the human MARF1 NYN domain, which we demonstrate is a bona fide endoribonuclease, the activity of which is essential for the repression of MARF1-targeted mRNAs. …”
Publicado 2018
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668“…In light of these findings, we analyzed the most commonly used bovine in vitro-derived APC models and compared them to bona fide DCs. Here, we show that bovine monocyte-derived DCs and Macs can be differentiated on the basis of CD11c and MHC class II (MHCII) expression and that in vitro conditions generate a heterologous group of both DCs and Macs with defined and specific biological activities. …”
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669“…Computational experiments highlighted that in Hi-C studies with short read lengths, mHi-C rescued multi-reads can emulate the effect of longer reads. mHi-C also revealed biologically supported bona fide promoter-enhancer interactions and topologically associating domains involving repetitive genomic regions, thereby unlocking a previously masked portion of the genome for conformation capture studies.…”
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670por Flamant, Stéphane, Chomel, Jean-Claude, Desterke, Christophe, Féraud, Olivier, Gobbo, Emilie, Mitjavila-Garcia, Maria-Teresa, Foudi, Adlen, Griscelli, Frank, Turhan, Ali G., Bennaceur-Griscelli, Annelise“…Our results pave the way for future genetic manipulation of hPSCs aimed at increasing their blood regenerative potential and designing better protocols for the generation of bona fide hPSC-derived hematopoietic stem cells.…”
Publicado 2019
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671“…The AUG circRNAs contain part of bona fide open reading frame, and in the recent years, several studies have reported cases of circRNA translation. …”
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672por Hu, Tao, Huang, Changjun, He, Yuting, Castillo-González, Claudia, Gui, Xiaojian, Wang, Yaqin, Zhang, Xiuren, Zhou, Xueping“…Here, we identified two components of a host mitogen-activated protein kinase (MAPK) cascade, MKK2 and MPK4, as bona fide targets of the βC1 protein encoded by the betasatellite of tomato yellow leaf curl China virus (TYLCCNV). βC1 interacts with the kinase domain of MKK2 and inhibits its activity. …”
Publicado 2019
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673por Chua, Min‐Wen Jason, Yildirim, Ege Deniz, Tan, Jun‐Hao Elwin, Chua, Yan‐Jiang Benjamin, Low, Suet‐Mei Crystal, Ding, Suet Lee Shirley, Li, Chun‐wei, Jiang, Zongmin, Teh, Bin Tean, Yu, Kang, Shyh‐Chang, Ng“…RESULTS: Our results show that, while all the strategies above are suboptimal at generating bona fide human myoblasts that can both proliferate and differentiate robustly, chemically defined hESC‐monolayer‐myoblasts show the most promise in differentiation potential. …”
Publicado 2019
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674“…Thus, molecular markers allowing identification of bona fide CAF populations with tumor-promoting traits remain under investigation. …”
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675por Castelo-Szekely, Violeta, De Matos, Mara, Tusup, Marina, Pascolo, Steve, Ule, Jernej, Gatfield, David“…Notably, these experiments revealed an alternative downstream start codon, likely representing the bona fide CLOCK N-terminus. Our findings provide insights into uORF-mediated translational regulation that can regulate the mammalian circadian clock and gene expression at large.…”
Publicado 2019
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676por Wang, Mengdie, Knudsen, Beatrice S., Nagle, Raymond B., Rogers, Gregory C., Cress, Anne E.“…We tested multiple anti-centriole and pericentriolar-material antibodies to identify bona fide centrosomes and multiplexed these with cell border markers to identify individual cells within the tissue. …”
Publicado 2019
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677por Sun, Weijia, Chi, Shaopeng, Li, Yuheng, Ling, Shukuan, Tan, Yingjun, Xu, Youjia, Jiang, Fan, Li, Jianwei, Liu, Caizhi, Zhong, Guohui, Cao, Dengchao, Jin, Xiaoyan, Zhao, Dingsheng, Gao, Xingcheng, Liu, Zizhong, Xiao, Bailong, Li, Yingxian“…Here we report that Piezo1, a bona fide mechanotransducer that is critical for various biological processes, plays a critical role in bone formation. …”
Publicado 2019
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678por Wang, Tongxin, Johnson, Travis S., Shao, Wei, Lu, Zixiao, Helm, Bryan R., Zhang, Jie, Huang, Kun“…To fully utilize the power of single-cell RNA sequencing (scRNA-seq) technologies for identifying cell lineages and bona fide transcriptional signals, it is necessary to combine data from multiple experiments. …”
Publicado 2019
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679“…We discuss how such membrane compartmentalization may be generated and maintained in a mycobacterial cell and why it has not evolved into a bona fide organelle. In a broader perspective, we suggest that segregation of biosynthetic pathways into different domains of a planar membrane could be more widespread than we currently think.…”
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680por Cuesta, Rebeca, Yuste-Calvo, Carmen, Gil-Cartón, David, Sánchez, Flora, Ponz, Fernando, Valle, Mikel“…Turnip mosaic virus (TuMV), a potyvirus, is a flexible filamentous plant virus that displays a helical arrangement of coat protein copies (CPs) bound to the ssRNA genome. TuMV is a bona fide representative of the Potyvirus genus, one of most abundant groups of plant viruses, which displays a very wide host range. …”
Publicado 2019
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