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761por Dugré-Brisson, Samuel, Elvira, George, Boulay, Karine, Chatel-Chaix, Laurent, Mouland, Andrew J., DesGroseillers, Luc“…In addition, similar up-regulation of translation was observed when Staufen1 was tethered to the 5′ end of mRNAs via other structured RNAs, the highest level of translational increase being obtained with the bona fide Staufen1-binding site of the Arf1 transcript. …”
Publicado 2005
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762por Churbanov, Alexander, Rogozin, Igor B., Babenko, Vladimir N., Ali, Hesham, Koonin, Eugene V.“…This effect is likely to reflect, primarily, bona fide evolutionary conservation, rather than cDNA annotation artifacts, because the excess of conserved upstream AUGs (uAUGs) is seen in 5′-UTRs containing stop codons in-frame with the start AUG and many of the conserved AUGs are found in different frames, consistent with the location in authentic non-coding sequences. …”
Publicado 2005
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763“…CONCLUSIONS/SIGNIFICANCE: In addition to delineating NS cells as a potential donor source for myelin repair, our data strongly support the view that these adherently expandable cells represent bona fide tripotential neural stem cells.…”
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764“…Molecular analyses indicated that these DBD-SB fusion proteins retained DNA-binding specificity for their respective substrate molecules and were capable of mediating bona fide transposition reactions. We also characterized transposon integrations in the presence of the E2C-SB fusion protein to determine its potential to target predefined DNA sites. …”
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765por Petz, Michaela, Kozina, Daniela, Huber, Heidemarie, Siwiec, Tanja, Seipelt, Joachim, Sommergruber, Wolfgang, Mikulits, Wolfgang“…Together, these data provide first evidence that the 5′-UTR of LamB1 contains a bona fide IRES that directs translational upregulation of LamB1 during stress conditions and neoplastic progression of hepatocytes.…”
Publicado 2007
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766“…These results indicate that Vif is a bona fide RNA chaperone. We next studied the effects of Vif in the presence of HIV-1 NCp, which is a well-established RNA chaperone. …”
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767“…RESULTS: Here, we report that a general feature of nematode MBD2/3 proteins seems to be the lack of a bona fide methyl-binding domain. We isolated a null allele of mbd-2 in P. pacificus and show that Ppa-mbd-2 mutants are viable, fertile and display a fully penetrant egg laying defect. …”
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768Publicado 1995“…Purification and characterization of Tpm2p revealed a protein with the characteristics of a bona fide tropomyosin; it is present in vivo at about one sixth the abundance of Tpm1p. …”
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769Publicado 1995“…In the absence of K14, K15 makes a bona fide, but ultrastructurally distinct, keratin filament network with K5. …”
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770Publicado 1996“…Immunoprecipitations and affinity chromatography also revealed that actin is not a bona fide component of dynactin. Our results indicate that spectrin is associated with the dynactin complex. …”
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771Publicado 1986“…In this report we study whether AK cells use a similar or a different target cell recognition system than that of bona fide CTL. To this end, we selected from a cloned AK line variants that are partially or completely deficient in specific target recognition and/or in cytotoxic function, and analyzed these variants for expression of the T cell antigen receptor and of Lyt-2. …”
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772por Delevoye, Cédric, Nilges, Michael, Dehoux, Pierre, Paumet, Fabienne, Perrinet, Stéphanie, Dautry-Varsat, Alice, Subtil, Agathe“…The analysis of intermolecular contacts showed that the IncA SNARE-like motif can make specific interactions with host SNARE motifs similar to those found in a bona fide SNARE complex. Moreover, point mutations in the central layer of IncA SNARE-like motifs resulted in the loss of binding to host SNAREs. …”
Publicado 2008
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773por Pugh, T. J., Delaney, A. D., Farnoud, N., Flibotte, S., Griffith, M., Li, H. I., Qian, H., Farinha, P., Gascoyne, R. D., Marra, M. A.“…We demonstrated that the WGA procedure introduces hundreds of potentially confounding CNV artifacts that can obscure detection of bona fide variants. Our analysis indicates that many artifacts are reproducible, and may correlate with proximity to chromosome ends and GC content. …”
Publicado 2008
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774“…RNA binding and ATPase stimulation are necessary, but not sufficient criteria for a bona fide helicase substrate. Here, we report single molecule FRET experiments that identify fragments of the 23S rRNA comprising hairpin 92 and RNase P RNA as substrates for the Thermus thermophilus DEAD box helicase Hera. …”
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775por Gontan, Cristina, Güttler, Thomas, Engelen, Erik, Demmers, Jeroen, Fornerod, Maarten, Grosveld, Frank G., Tibboel, Dick, Görlich, Dirk, Poot, Raymond A., Rottier, Robbert J.“…We show that, besides its established function in nuclear export, Exp4 acts as a bona fide nuclear import receptor for Sox2 and SRY. Thus, Exp4 is an example of a nuclear transport receptor carrying distinct cargoes into different directions. …”
Publicado 2009
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776“…Consistently, the siRNA duplexes determined to confer ASP-RNAi also inhibited the expression of the bona fide mutant APP and the production of either amyloid β 40- or 42-peptide in Cos-7 cells expressing both the full-length Swedish- and wild-type APP alleles. …”
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777“…We conclude that, while there are bona fide new intergenic transcripts, their number and abundance is generally low in comparison to known exons, and the genome is not as pervasively transcribed as previously reported.…”
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778“…CONCLUSIONS AND SIGNIFICANCE: Thus, our results indicate that the TSE represents a bona fide piRNA-based repression. In addition, the sensitivity of TSE to HP1 dose suggests that in Drosophila, as previously shown in Schizosaccharomyces pombe, a RNA silencing pathway can depend on heterochromatin components.…”
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779“…In summary, rat SYT4 serves as an inhibitory isoform, whereas fly SYT4 is a bona fide Ca(2+) sensor capable of coupling Ca(2+) to membrane fusion.…”
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780por Sullivan, Matthew J., Curson, Andrew R. J., Shearer, Neil, Todd, Jonathan D., Green, Robert T., Johnston, Andrew W. B.“…Transcription of the operon was enhanced when cells were pre-grown with the substrate DMSP, but this induction is indirect, and requires the conversion of DMSP to the product acrylate, the bona fide co-inducer. This regulation is mediated by the product of the promoter-proximal gene acuR, a transcriptional regulator in the TetR family. …”
Publicado 2011
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