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Mostrando 801 - 820 Resultados de 2,933 Para Buscar '"FIDE"', tiempo de consulta: 0.45s Limitar resultados
  1. 801
    “…Gene profiling experiments revealed that, although hESC-MP derived cells expressed a suite of cardiac related genes, they lacked the complete repertoire of genes associated with bona fide cardiomyocytes. Our results suggest that whilst agents such as TGF-β1 and 5-Azacytidine can induce expression of cardiac related genes, but treated cells retain a mesenchymal like phenotype.…”
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    Human Embryonic Stem Cell Derived Mesenchymal Progenitors Express Cardiac Markers but Do Not Form Contractile Cardiomyocytes
  2. 802
    “…Here we report that the eukaryote Acanthamoeba castellanii lacks the G(−1) identity element on its tRNA(His), consistent with the lack of a gene encoding a bona fide Thg1 ortholog in the A. castellanii genome. …”
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    Absence of a universal element for tRNA(His) identity in Acanthamoeba castellanii
  3. 803
    “…In this study bioinformatic analyses indicated a single copy orthologue of the putative SM synthase from the apicomplexan Plasmodium falciparum (the causative agent of malaria) was a bona fide sphingolipid synthase in the related model parasite, Toxoplasma gondii (TgSLS). …”
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    Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii
  4. 804
    “…The data provides the first example of genome wide Runx1/p300 occupancy in maturating primary FL-MK, unravel the Runx1-regulated program controlling MK maturation in vivo and identify a subset of its bona fide regulated genes. It advances our understanding of the molecular events that upon RUNX1mutations in human lead to the predisposition to familial platelet disorders and FPD-AML.…”
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    Cell-Autonomous Function of Runx1 Transcriptionally Regulates Mouse Megakaryocytic Maturation
  5. 805
    “…Here, we show that geminin, like cyclin B1 and securin, is a bona fide target of the spindle checkpoint and APC/C(Cdc20). …”
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    The spindle checkpoint, APC/C(Cdc20), and APC/C(Cdh1) play distinct roles in connecting mitosis to S phase
  6. 806
    “…To investigate whether aberrant hypermethylation is a mechanism of inactivation of these tumor suppressor genes in ccRCC, we sequenced the promoter region within a bona fide CpG island of PBRM1, KDM6A, SETD2 and BAP1 in bisulfite-modified DNA of a representative series of 50 primary ccRCC, 4 normal renal parenchyma specimens and 5 RCC cell lines. …”
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    Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC
  7. 807
    “…The majority of these mutations lead to a loss of expression of the ARID1A protein, which is a subunit of the SWI/SNF chromatin remodeling complex and considered as a bona fide tumor suppressor. ARID1A mutations frequently co-occur with mutations, leading to an activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, such as mutations in PIK3CA encoding the catalytic subunit, p110α, of PI3K. …”
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    ARID1A Mutations and PI3K/AKT Pathway Alterations in Endometriosis and Endometriosis-Associated Ovarian Carcinomas
  8. 808
    “…From a given predicted proteome, we identify all bona fide ion channels, ion porters, and ion pumps. Concentrating on unicellular eukaryotes (n = 37), we demonstrate that clustering of species according to their repertoire of ion transporters segregates obligate endoparasites (n = 23) on the one hand, from free-living species and facultative parasites (n = 14) on the other hand. …”
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    In Silico Ionomics Segregates Parasitic from Free-Living Eukaryotes
  9. 809
    “…To determine whether these putative RTG2 ORFs encoded bona fide regulators of retrograde signaling, we tested their ability to complement the defects associated with the S. cerevisiae rtg2Δ mutant. …”
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    Characterization of fungal RTG2 genes in retrograde signaling of Saccharomyces cerevisiae
  10. 810
    “…In addition, we show by chromatin immunoprecipitations, luciferase assays and Northern blot experiments that HEY1 is a bona fide target of the E2F family of transcription factors, connecting the Ras and Notch signalling pathways. …”
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    A role for the transcription factor HEY1 in glioblastoma
  11. 811
    por Prochiantz, A
    Publicado 2013
    “…Indeed complexity has been added in the course of evolution and the conservation of homeoprotein transduction is discussed in the context of its synergy with bona fide signaling mechanism that may have added robustness to this primitive cell communication device. …”
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    Signaling with Homeoprotein Transcription Factors in Development and Throughout Adulthood
  12. 812
    “…Our results establish metacaspase-dependent autophagy as a bona fide mechanism that is responsible for cell disassembly during vacuolar cell death and for inhibition of necrosis.…”
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    Autophagy and metacaspase determine the mode of cell death in plants
  13. 813
    “…In parallel, we validate CUX1 as a bona fide tumor suppressor using mouse transposon-mediated insertional mutagenesis and Drosophila cancer models. …”
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    Inactivating CUX1 mutations promote tumorigenesis
  14. 814
    “…Numerous observations link caspase-2 to the disruption of the cytoskeleton, although it remains elusive whether any of the cytoskeleton proteins serve as bona fide substrates for caspase-2. Here, we undertook an unbiased proteomic approach to address this question. …”
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    Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death
  15. 815
    “…Based on our results, we suggest that the role of PER proteins as bona fide tumor suppressors needs to be reevaluated.…”
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    Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis
  16. 816
    “…In contrast to known translocation signals we show that TSA is an independent folding unit and thus forms a bona fide structural domain. This domain can be further divided into three subdomains with striking structural homology with helicase subdomains of the SF1B family. …”
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    Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems
  17. 817
    “…Following a morphological adjustment driven by occurrence, enlargement and/or fusion process of intracellular vacuoles, similar to that described in bona fide endothelium, a subpopulation of these cells end up by lining a capillary-like lumen in vitro. …”
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    A subpopulation of peritoneal macrophages form capillary-like lumens and branching patterns in vitro
  18. 818
    “…Recent studies have revealed that ARID1A is frequently mutated across a wide variety of human cancers and also has bona fide tumor suppressor properties. Consequently, identification of vulnerabilities conferred by ARID1A mutation would have major relevance for human cancer. …”
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    ARID1B is a specific vulnerability in ARID1A-mutant cancers
  19. 819
    “…In vitro, Abl phosphorylates CLASP with a Km of 1.89 µM, indicating that CLASP is a bona fide substrate. Abl-phosphorylated tyrosine residues that we detect in CLASP by mass spectrometry lie within previously mapped F-actin and MT plus end interaction domains. …”
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    Abelson Phosphorylation of CLASP2 Modulates its Association With Microtubules and Actin
  20. 820
    “…By target gene prediction and experimental validation, we demonstrated that caveolin-1 (Cav-1) may be a bona fide target of miR-199a-5p in porcine adipocytes, accounting for some of miR-199a-5p’s functions. …”
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    MicroRNA-199a-5p Affects Porcine Preadipocyte Proliferation and Differentiation
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