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Mostrando 861 - 880 Resultados de 2,933 Para Buscar '"FIDE"', tiempo de consulta: 0.31s Limitar resultados
  1. 861
    “…We demonstrate TaU4 to be a bona fide E2 enzyme through an E2 charging assay. TaU4 localises in both the cytoplasm and nucleus, therefore potentially interacting with E3 ligases and substrate proteins in multiple compartments. …”
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    The ubiquitin conjugating enzyme, TaU4 regulates wheat defence against the phytopathogen Zymoseptoria tritici
  2. 862
    “…Taken together, our results lend strong support for the hypothesis that tetrapods inherited a bona fide limb regeneration programme concomitant with the fin-to-limb transition.…”
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    Tetrapod limb and sarcopterygian fin regeneration share a core genetic programme
  3. 863
    “…However, in contrast to other cell types of the human CNS, bona fide microglia have not yet been derived from cultured human pluripotent stem cells. …”
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    Efficient derivation of microglia-like cells from human pluripotent stem cells
  4. 864
    “…This report demonstrates the importance of Kin17 as a critical factor that acts prior to the repair phase of DSB repair and is of bona fide importance for CSR.…”
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    Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching
  5. 865
    por Xu, Hongwei, Zhan, Wang, Chen, Zhiyuan
    Publicado 2016
    “…BACKGROUND: The ras-association domain family 1 isoform A (RASSF1A) gene serves as a bona fide tumor suppressor gene. The polymorphisms in RASSF1A were previously reported to be associated with the risk of solid malignant tumors. …”
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    Ras-Association Domain Family 1 Isoform A (RASSF1A) Gene Polymorphism rs1989839 is Associated with Risk and Metastatic Potential of Osteosarcoma in Young Chinese Individuals: A Multi-Center, Case-Control Study
  6. 866
    “…Here, we show that neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4), an E3 ubiquitin ligase, interacts with the hinge and ligand binding domains of PPARγ and is a bona fide E3 ligase for PPARγ. NEDD4 increases PPARγ stability through the inhibition of its proteasomal degradation. …”
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    Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells
  7. 867
    “…Lastly, we demonstrate that the mammary-enriched transcription factors GR, ELF5 and NFIB associate with STAT5 at sites lacking bona fide binding motifs. This study provides, for the first time, molecular insight into the differential sensitivities of mammary-specific and universal cytokine-sensing enhancers.…”
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    Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation
  8. 868
    “…Cells with the phenotype, morphology and functional features of monocyte-derived DC, bona fide DC or macrophages were obtained in GM-CSF/IL4, FLT3L or CSF-1 cultures, respectively. …”
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    Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
  9. 869
    “…Some archaea possess bona fide RuBisCOs, despite not being photosynthetic organisms, but are thought to lack PRK. …”
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    A RuBisCO-mediated carbon metabolic pathway in methanogenic archaea
  10. 870
    “…To identify putatively causal regulators, we performed transcription factor binding site overrepresentation analyses in active chromatin regions and prioritized factors based on their expression correlation with the bona-fide brown adipogenic marker Ucp1 across multiple mouse and human datasets. …”
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    Dissecting the brown adipogenic regulatory network using integrative genomics
  11. 871
    “…We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snail1. …”
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    Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation
  12. 872
    “…These and other considerations make it difficult to view some IHA as a bona fide medical activity. To allow it to be viewed as such requires that it be conducted within a robust clinical governance framework that includes regulatory dimensions.…”
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    Justification of CT for Individual Health Assessment of Asymptomatic Persons: A World Health Organization Consultation
  13. 873
    “…We found that SUMO2/3 conjugates accumulate during the late phase of the productive virus cycle, and identified several viral proteins as bone fide SUMOylation substrates. Analysis of the mechanism involved in the accumulation of SUMOylated proteins revealed upregulation of several components of the SUMO-conjugation machinery and post-transcriptional downregulation of the SUMO-targeted ubiquitin ligase RNF4. …”
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    The Epstein-Barr virus miR-BHRF1-1 targets RNF4 during productive infection to promote the accumulation of SUMO conjugates and the release of infectious virus
  14. 874
    “…The epiblast of the early mammalian embryo is the founder population of all germ layer derivatives and thus represents the bona fide in vivo pluripotent cell population. The so-called pluripotent state spans several days of development and is lost during gastrulation as epiblast cells make fate decisions towards a mesoderm, endoderm or ectoderm identity. …”
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    The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states
  15. 875
    “…The neurogenin 3 gene (Ngn3) is a bona fide target of ZEB1, and its repression is a key factor contributing to ZEB1-induced cancer cell stemness. …”
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    ZEB1 confers stem cell-like properties in breast cancer by targeting neurogenin-3
  16. 876
    por Krupovic, Mart, Koonin, Eugene V.
    Publicado 2017
    “…Here, using structural and sequence comparisons, we show that both BMC-H and BMC-P, most likely, were exapted from bona fide cellular proteins, namely, PII signaling protein and OB-fold domain-containing protein, respectively. …”
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    Cellular origin of the viral capsid-like bacterial microcompartments
  17. 877
    “…Our data suggest a molecular mechanism underlying the transition between a better-known repressive function of PTBP1 and its role as a bona fide splicing activator. More generally, we argue that the functional outcome of individual RNA contacts made by an RNA-binding protein is subject to extensive context-specific modulation.…”
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    A mechanism underlying position-specific regulation of alternative splicing
  18. 878
    “…We further address the relationships of the archaeal family of KaiC homologues to the bona fide KaiC of cyanobacteria and implications for the existence of a KaiC-based circadian clock apparatus in archaea.…”
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    Proposed Role for KaiC-Like ATPases as Major Signal Transduction Hubs in Archaea
  19. 879
    “…Moreover, the nature of the cells reconstituted after transplantation and whether they could comprise bona fide microglia remain to be assessed. We demonstrate that transplantation of HSPCs in the cerebral lateral ventricles provides rapid engraftment of morphologically, antigenically, and transcriptionally dependable microglia-like cells. …”
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    Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells
  20. 880
    “…Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity, and memory recall.…”
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    The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory
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