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  1. 961
    “…There may also be considerable immunity generated against bacterial DNA, although the relative contribution of self-targeting versus bona fide intra- or inter-species targeting needs to be investigated further. …”
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    Investigating CRISPR spacer targets and their impact on genomic diversification of Streptococcus mutans
  2. 962
    por Li, Qiwen, Xu, Ruoshi, Lei, Kexin, Yuan, Quan
    Publicado 2022
    “…We discuss the principles and approaches to identify bona fide SSCs, highlighting pioneering findings that plot the lineage atlas of SSCs. …”
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    Insights into skeletal stem cells
  3. 963
    “…Yet, there is limited evidence supporting the notion that the reprogrammed cellular metabolism of the regenerated tissued confers bona fide antimicrobial activity. Here, we explored the anti-bacterial activity of protocorm-like-bodies (PLBs) of Phalaenopsis aphrodite. …”
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    Protocorm-like-body extract of Phalaenopsis aphrodite combats watermelon fruit blotch disease
  4. 964
    “…The results of multiple sequence alignment revealed that, unlike CnCHI1/5/6/7, CnCHI2/3/4 are bona fide CHIs that contain all the active site and critical catalytic residues. …”
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    Identification of Chalcone Isomerase Family Genes and Roles of CnCHI4 in Flavonoid Metabolism in Camellia nitidissima
  5. 965
    “…The member of group I, called bona fide CAD, was involved in lignin synthesis. Most of the members of group II were involved in stress resistance. …”
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    Identification and Functional Analysis of CAD Gene Family in Pomegranate (Punica granatum)
  6. 966
    “…Here, we provide evidence that POT-3 is a bona fide telomere-binding protein. Using a new loss-of-function mutant, we show that the absence of POT-3 causes telomere lengthening and increased levels of telomeric C-circles. …”
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    POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang
  7. 967
    “…To study if the IDO blockade strategy can be translated to a bona fide host-directed therapy in the clinical setting of TB, we studied the effect of IDO inhibitor 1-methyl-d-tryptophan adjunctive to suboptimal anti-TB chemotherapy. …”
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    Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy
  8. 968
    “…This approach induces canonical MN markers including MN-specific Hb9/MNX1 in more than 95% of cells. liMNs resemble bona fide hPSC-derived MN, exhibit spontaneous electrical activity, express synaptic markers, and can contact muscle cells in vitro. …”
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    Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues
  9. 969
    “…We established an in vitro model of chronic stimulation and benchmarked key phenotypic, functional, transcriptional, and epigenetic features against bona fide in vivo T(ex). We leveraged this model of in vitro chronic stimulation in combination with pooled CRISPR screening to uncover transcriptional regulators of T cell exhaustion. …”
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    In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40
  10. 970
    “…RNAcontacts circumvents the inherent problem of mapping sequences with two distinct types of splits using a two-pass alignment, in which splice junctions are inferred from a control RNA-seq experiment on the first pass and then provided to the aligner as bona fide introns on the second pass. Compared to previously developed methods, our approach allows for a more sensitive detection of RNA contacts and has a higher specificity with respect to splice junctions that are present in the biological sample. …”
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    RNAcontacts: A Pipeline for Predicting Contacts from RNA Proximity Ligation Assays
  11. 971
    “…We confirmed that Arp8, a component of the INO80 chromatin remodeling complex, is a bona fide substrate of Hhp1 and Hhp2 that is important for DSB repair. …”
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    Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining
  12. 972
    “…However, the use of conventional markers of CSCs is still insufficient for the isolation of bona fide CSCs. We investigated organoids that are miniature forms of tumor tissues by reconstructing cellular diversity to identify specific markers to characterize CSCs in heterogeneous tumors. …”
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    RHAMM marks proliferative subpopulation of human colorectal cancer stem cells
  13. 973
    “…We determine that these mutant proteins are all bona fide Pim1p substrates whose degradation is also blocked in respiratory-deficient “petite” yeast cells, such as in cells lacking m-AAA protease subunits. …”
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    Differential sensitivity of the yeast Lon protease Pim1p to impaired mitochondrial respiration
  14. 974
    “…Injection of OCs into adult male flies induces a strong transcriptomic response in the host flies featuring in particular genes encoding bona fide G coupled proteins, among which the gene for methuselah like 1 is prominent. …”
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    mthl1, a potential Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies
  15. 975
    “…To ameliorate these issues, we discuss orthogonal methods that can be used to characterize bona fide chromatin-associated proteins. Conclusions: Our results highlight the impact of chromatin structure on genome-wide analyses in the parasite and the need for caution when characterizing chromatin-associated proteins and features.…”
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    Chromatin structure can introduce systematic biases in genome-wide analyses of Plasmodium falciparum
  16. 976
    “…We found that S. hermonthica elicits both basal and effector-triggered immunity—like a bona fide pathogen. The resistance response was genotype specific. …”
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    Resolving intergenotypic Striga resistance in sorghum
  17. 977
    “…Manipulation of the extracellular Fgf8a levels alters the signaling outcome, thus establishing Fgf8a as a bona fide morphogen during zebrafish gastrulation. Furthermore, by hindering Fgf8a diffusion, we demonstrate that extracellular diffusion of the protein from the source is crucial for it to achieve its morphogenic potential.…”
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    Real-time monitoring of an endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation
  18. 978
    “…This work uncovers TIM-3 as a bona fide target in DIPG and supports its clinical translation.…”
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
  19. 979
    “…Acetylene, a potent inhibitor of the related enzyme soluble methane monooxygenase, had little inhibitory effect, whereas 1‐octyne was a potent inhibitor of isoprene monooxygenase, indicating that 1‐octyne could potentially be used as a specific inhibitor to differentiate between isoprene consumption by bona fide isoprene degraders and co‐oxidation of isoprene by other oxygenase‐containing bacteria, such as methanotrophs, in environmental samples. …”
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    Whole‐cell studies of substrate and inhibitor specificity of isoprene monooxygenase and related enzymes
  20. 980
    “…Our data confirm the predictive accuracy of AI platforms modelling bona fide immunogenicity and provide a novel framework for the evaluation of vaccine-induced T cell responses.…”
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    Experimental validation of immunogenic SARS-CoV-2 T cell epitopes identified by artificial intelligence
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