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  1. 1121
    “…Indeed, the exogenous application of a single recombinant insulin-like peptide cloned from the Aplysia CNS cDNA replicated both the enhancement of synaptic transmission, the reduction of excitability, and promoted clearance of glucose from the hemolymph, a hallmark of bona fide insulin action.…”
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    Neurotropic and modulatory effects of insulin-like growth factor II in Aplysia
  2. 1122
    “…Emerging evidences have shown that the PP2A phosphatase functions as a bona-fide therapeutic target for anticancer therapy, but it is unclear whether PP2A affects a porcine reproductive and respiratory syndrome virus infection. …”
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    PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production
  3. 1123
    “…Our method can identify known clusters and bona-fide cancer drivers across cohorts of tumor whole-exomes, outperforming the existing OncodriveCLUST algorithm and complementing other methods based on different signals of positive selection. …”
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    OncodriveCLUSTL: a sequence-based clustering method to identify cancer drivers
  4. 1124
    “…We demonstrated that the full-length RopA and RopB form bona fide amyloid fibrils in vitro. In particular, these fibrils are β-sheet-rich, bind Thioflavin T (ThT), exhibit green birefringence upon staining with Congo Red (CR), and resist treatment with ionic detergents and proteases. …”
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    Two Novel Amyloid Proteins, RopA and RopB, from the Root Nodule Bacterium Rhizobium leguminosarum
  5. 1125
    “…We identified that the 5′ flanking region (− 1856 bp ~ + 468 bp) of the human USP16 gene contained the functional promotor to control its transcription. Three bona fide NFκB binding sites were found in USP16 promoter. …”
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    Transcriptional activation of USP16 gene expression by NFκB signaling
  6. 1126
    “…Altogether, we demonstrate for the first time that CgYapsins are both bona fide constituents and key modulators of the C. glabrata secretome.…”
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    Global Secretome Characterization of the Pathogenic Yeast Candida glabrata
  7. 1127
    “…High mobility group B1 (HMGB1), a bona fide alarmin/DAMP, may be released passively by necrotic cells or actively secreted by innate immune cells. …”
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    Macrophage‐derived HMGB1 is dispensable for tissue fibrogenesis
  8. 1128
    “…Although the combined modifications of retargeted gD allowed bona fide retargeting, incorporation into virions was partially compromised. …”
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    Point Mutations in Retargeted gD Eliminate the Sensitivity of EGFR/EGFRvIII-Targeted HSV to Key Neutralizing Antibodies
  9. 1129
    por Liu, Ning, Bao, Guoxian, He, Alex Jingwei
    Publicado 2020
    “…This study argues that health policy interventions aimed at curbing informal payments must be based on a thorough understanding of their complex socioeconomic causes and attack the perverse incentives in a coherent and bona fide manner.…”
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    Does health insurance coverage reduce informal payments? Evidence from the “red envelopes” in China
  10. 1130
    “…Its constitutive expression on resting and activated T cells precludes it from being a bona fide exhaustion marker. By breeding Pmel-1 mice with SLAMF6 -/- mice, we generated donors for T cells lacking SLAMF6 and expressing a transgenic TCR for gp100-melanoma antigen. …”
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    SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint
  11. 1131
    “…In this perspective, we approach the problem from a different and complementary perspective by comparing the structure and sequence of Aβ(1-42) with those of bona fide antimicrobial peptides. We demonstrate that Aβ(1-42) bears convincing structural similarities with both viral fusion domains and antimicrobial peptides, as well as sequence similarities with a specific family of bacterial bacteriocins. …”
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    Why does the Aβ peptide of Alzheimer share structural similarity with antimicrobial peptides?
  12. 1132
    “…Among all of the Super Elongation Complex (SEC) components, ELL1 (also known as ELL) is the only bona fide elongation factor that directly stimulates transcription elongation by RNA polymerase II. …”
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    DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes
  13. 1133
    “…Our approach is applicable to long read sequencing data from any organism for accurate detection of bona fide mutations and inter-strain polymorphisms.…”
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    Direct sequencing of RNA with MinION Nanopore: detecting mutations based on associations
  14. 1134
    “…Further analysis revealed that CD24a was the bona fide marker for MDPSCs, and their expansion was highly dependent on the expression of a key transcriptional factor, Sp7. …”
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    Regeneration of pulpo-dentinal–like complex by a group of unique multipotent CD24a(+) stem cells
  15. 1135
    “…Moreover, SORE6 transcriptional activity is a bona fide CSC marker in sarcoma and constitutes an excellent biomarker for evaluating the efficacy of anti-tumor treatments on CSC subpopulations.…”
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    SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic Implications
  16. 1136
    “…Our data further validate the well-known positive effects of EVO supplementation in promoting human health and suggest the bona fide contribution of EVO in preventing onset and reducing progression of intestinal inflammation.…”
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    Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation
  17. 1137
    “…Collectively, we unravel that the metabolite pools are bona fide members of proteostasis and aid in mutational buffering. …”
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    Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
  18. 1138
    “…The role of bona fide epigenetic regulators in the process of neuronal transdifferentiation was until recently largely uncharacterized, despite their key role in the physiological processes of neural fate acquisition and maintenance. …”
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    KMT2B and Neuronal Transdifferentiation: Bridging Basic Chromatin Mechanisms to Disease Actionability
  19. 1139
    “…The molecular characterization of OsCHSs suggests that OsCHS8 and OsCHS24 belong in the bona fide CHSs, while the other members are categorized in the non-CHS group of type III polyketide synthases (PKSs). …”
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    Two Chalcone Synthase Isozymes Participate Redundantly in UV-Induced Sakuranetin Synthesis in Rice
  20. 1140
    “…Infected hovS cells produced proteinase K–resistant prion protein (PrP(Sc)), pelletable PrP aggregates, and bona fide infectious prions capable of infecting further generations of naïve hovS cells and mice expressing the VRQ allelic variant of ovine PrP(C). …”
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    Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line
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