“…Meaningful validation of predictions from modelled atherosclerotic plaque model typically requires examination of bona fide atherosclerotic lesions. To analyze a more accurate plaque rupture, fluid-structure interaction is applied to three-dimensional blood-vessel carotid bifurcation modelling. …”
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“…Additionally, using the mock community, we were able to evaluate contamination and select a relative abundance cut-off threshold based on the geometric distribution that optimizes the trade off between detecting bona fide operational taxonomic units and filtering out spurious ones. …”
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“…However, the experimental discovery and validation of bona fide granzyme B substrates require time consuming and laborious efforts. …”
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“…Based on these findings, we formalize and propose co-expression analysis as a general paradigm for second-generation procedures to recognize bona fide targets and infer biological roles and network communities of miRNAs.…”
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“…Altogether, we identified ANG-2 as a bona fide target gene of LMO2-complexes with TAL1 and/or LYL1, highlighting a new function of the three hematopoietic factors in the endothelial lineage.…”
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“…Using a transgenic mouse model, we have previously shown that constitutive active β-catenin is a bona fide adrenal oncogene. However, although all these mice developed benign adrenal hyperplasia, malignant progression was infrequent, suggesting that secondary genetic events were required for aggressive tumour development. …”
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“…While genetic approaches in budding yeast have identified bona fide export factors for mRNAs and pre60S subunits, little is known regarding nuclear export of pre40S subunits. …”
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“…Reporter assays showed that miR-210 inhibited ROD1 by the direct binding to this sequence, demonstrating that ROD1 is a bona fide seedless target of miR-210. As expected, both ROD1 mRNA and protein were down-modulated upon hypoxia in a miR-210 dependent manner. …”
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“…We therefore examined the transcriptional repressor Ets2-repressor factor (ERF)—a bona fide Ras–extracellular signal-regulated kinase/mitogen-activated protein kinase effector—for its ability to interfere with TGF-β–induced EMT in mammary epithelial cells (EpH4) expressing oncogenic Ras (EpRas). …”
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“…PasT-induced stasis can be rescued by overexpression of PasI, indicating that PasTI is a bona fide TA system. By mutagenesis, we find that the stress resistance and toxic effects of PasT can be uncoupled and mapped to distinct domains. …”
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“…THIS MULTIPRONGED EXPERIMENTAL APPROACH REVEALED THAT CISPLATIN ELICITS SIGNALING PATHWAYS THAT ARE FOR THE MOST PART “PRIVATE,” I.E., THAT MANIFEST LIMITED OVERLAP WITH THE MOLECULAR CASCADES IGNITED BY OTHER INDUCERS OF MITOCHONDRIAL APOPTOSIS, AND TRIGGERS APOPTOSIS MAINLY IN A TRANSCRIPTION-INDEPENDENT FASHION. INDEED, BONA FIDE CISPLATIN-RESPONSE MODIFIERS THAT WE HAVE RECENTLY IDENTIFIED BY A FUNCTIONAL GENOME-WIDE SIRNA SCREEN ARE EITHER NOT TRANSCRIPTIONALLY REGULATED DURING CISPLATIN-INDUCED CELL DEATH OR THEIR TRANSCRIPTIONAL MODULATION REFLECTS THE ACTIVATION OF AN ADAPTIVE RESPONSE PROMOTING CISPLATIN RESISTANCE:…”
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“…Using SHP2 substrate-trapping mutants and an in vitro phosphatase activity assay, we validate β-catenin as a bona fide SHP2 substrate. SHP2 silencing and SHP2 inhibition both result in delayed recovery of endothelial barrier function after thrombin stimulation. …”
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“…Specifically, we show that the ORFan gene 057w of the T4-related enterobacteriophage RB43 encodes a bona fide JDP protein, named Rki, which specifically interacts with the Escherichia coli host multifunctional DnaK chaperone. …”
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“…Using a novel form of the 4-1BBL costimulatory molecule, SA-4-1BBL, as the adjuvant of choice, we previously demonstrated that a single vaccination with survivin (SVN) as a bona fide self TAA was effective in eradicating weakly immunogenic 3LL tumors in >70% of C57BL/6 mice. …”
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“…Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse livers, the current study identifies the bona-fide hepatic RXRα targets and biological pathways. …”
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“…Solid tumors are constituted of a variety of cellular components, including bona fide malignant cells as well as endothelial, structural and immune cells. …”
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“…We now show that the C. neoformans Crz1 ortholog (Crz1/Sp1), previously identified as a protein kinase C target during starvation, is a bona fide target of calcineurin under non-starvation conditions, during cell wall stress and growth at high temperature. …”
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“…In contrast to nearly all eukaryotes, the Old World Leishmania species L. infantum and L. major lack the bona fide RNAi machinery genes. Interestingly, both Leishmania genomes code for an atypical Argonaute-like protein that possesses a PIWI domain but lacks the PAZ domain found in Argonautes from RNAi proficient organisms. …”
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“…The capacity of a virus to cross species barriers is determined by the development of bona fide interactions with cellular components of new hosts, and in particular its ability to block IFN-α/β antiviral signaling. …”
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“…The UBX domain protein Shp1 is a bona fide substrate-recruiting cofactor of Cdc48 in the budding yeast S. cerevisiae. …”
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