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  1. 1381
    “…Beyond existing annotations, we demonstrate that the ultra-high resolution of RNA-Seq combined from 462 individuals also provides evidence for thousands of bona fide novel elements of RNA processing—alternative splice sites, introns, and cleavage sites—which are often rare and lowly expressed but in other characteristics similar to their annotated counterparts.…”
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    Sequence variation between 462 human individuals fine-tunes functional sites of RNA processing
  2. 1382
    “…DdiTLP3 catalyzes tRNA repair during mitochondrial tRNA 5′-editing in vivo and in vitro, establishing template-dependent 3′-5′ polymerase activity of TLPs as a bona fide biological activity for the first time since its unexpected discovery more than a decade ago. …”
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    Identification of distinct biological functions for four 3′-5′ RNA polymerases
  3. 1383
    “…We identified erlotinib as an inducer of YAP cytoplasmic localization, an inhibitor of the TEA luciferase reporter system and the expression of the bona fide YAP target gene, Connective Tissue Growth Factor CTGF. …”
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    The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level
  4. 1384
    “…When translated in vitro, LITAF integrates poorly into ER-derived microsomes compared with Sec61β, a bona fide TA protein. Furthermore, introduction of N-linked glycosylation reporters shows that neither the N-terminal nor C-terminal domains of LITAF translocate into the ER lumen. …”
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    The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein
  5. 1385
    “…These results showed that multipotent epitheliomesenchymal GSCs are present in glandular mesenchyme, and that isolation of homogenous GSC clones from human salivary glands may promote the precise understanding of biological function of bona fide GSCs, enabling their therapeutic application for salivary gland regeneration.…”
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    Single Cell Clones Purified from Human Parotid Glands Display Features of Multipotent Epitheliomesenchymal Stem Cells
  6. 1386
    “…Fumarate, a small molecule metabolite that accumulates in FH-deficient cells, plays a key role in cell transformation, making it a bona fide oncometabolite3. Fumarate was shown to inhibit α-ketoglutarate (aKG)-dependent dioxygenases involved in DNA and histone demethylation4,5. …”
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    Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
  7. 1387
    “…RESULTS: Analysis at the genomic level of 67 tumour samples and 37 cell lines revealed at least 2 bona-fide mutations in cell lines without allelic loss at 11q23: a 4bp-deletion causing skip of exon 3 resulting in a premature stop codon in cell line N206, and a Y93C mutation in cell line NMB located in a region affected by germline SDHD mutations causing hereditary paraganglioma. …”
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    No evidence for involvement of SDHD in neuroblastoma pathogenesis
  8. 1388
    “…Using an in vitro microscopy assay, we find that purified Dis1 autonomously tracks growing microtubule ends and is a bona fide microtubule polymerase. Mal3 recruits additional Dis1 to microtubule ends, explaining the synergistic enhancement of microtubule dynamicity by these proteins. …”
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    An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation
  9. 1389
    “…Taken together, these data uncover TRIM25 as a bona fide ZAP cofactor that leads to increased ZAP modification enhancing its translational inhibition activity.…”
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    TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)
  10. 1390
    “…For further test development, an additional “test” set of 33 chemicals considered to act directly as bona fide DNT toxicants is proposed, and each chemical is annotated to the extent it fulfills these criteria. …”
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    Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use
  11. 1391
    “…Importantly, among these were mRNAs encoding bona fide peroxisomal proteins, such as peroxins and peroxisomal matrix enzymes involved in beta-oxidation of fatty acids and bile acid biosynthesis. …”
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    Genome-wide analysis of mRNAs associated with mouse peroxisomes
  12. 1392
    “…Taken together, these data identify HUWE1 as a bona fide tumour suppressor gene in the intestinal epithelium and suggest a potential vulnerability of HUWE1‐mutated tumours to DNA‐damaging agents and inhibitors of anti‐apoptotic proteins.…”
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    HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation
  13. 1393
    “…Here we report a predicted protein from Lingulodinium polyedrum that displays hallmark properties of bona fide H(V)1, including time-dependent opening with depolarization, perfect proton selectivity, and characteristic ΔpH dependent gating. …”
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    Identification of a vacuolar proton channel that triggers the bioluminescent flash in dinoflagellates
  14. 1394
    por Alderman, Christopher, Yang, Yixin
    Publicado 2016
    “…CDCA4 was also discovered as a novel bona-fide target of miRNA-15a. The following oncogenic mRNAs are verified targets of miRNA-15a: CDCA4, BCL2L2, YAP1, AKT-3, Cyclin E1, and γ-Synuclein. …”
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    The anti-melanoma activity and oncogenic targets of hsa-miR-15a-5p
  15. 1395
    “…FASN contributes to mammary oncogenesis and serves as a bona fide target in cancer therapies. MicroRNAs inhibit gene expression through blocking mRNA translation or promoting mRNA degradation by targeting their 3′-UTRs. …”
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    Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer
  16. 1396
    “…Ccn6(fl/fl) ;MMTV-Cre mice developed invasive high grade mammary carcinomas with bona fide EMT, histologically similar to human metaplastic breast carcinomas. …”
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    MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas
  17. 1397
    “…Conversely, selfing (or asexuality) makes it possible for polyploid species to originate from a single individual—a bona fide speciation event. The extent to which this happens is not known. …”
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    Genome Sequencing Reveals the Origin of the Allotetraploid Arabidopsis suecica
  18. 1398
    “…We show that lysophosphatidic acid/protein kinase D1 (LPA/PKD-1)-CD36 signaling is a bona fide breast cancer promoter via stimulating microvascular remodeling in chronic diet-induced obesity (DIO). …”
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    Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling
  19. 1399
    “…However, insufficient sensitivity prevents detection of proteins present at low concentrations and antibody cross-reactivity results in unspecific detection that cannot be distinguished from bona fide protein isoforms. By using DNA-conjugated antibodies enhanced signals can be obtained via rolling circle amplification (RCA). …”
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    Highly sensitive and specific protein detection via combined capillary isoelectric focusing and proximity ligation
  20. 1400
    “…PGE(2) binds its bona fide receptor EP3 which by activating SRC family kinases, induces ADAMs activation which, in turn, releases EGFR-ligands from the cell membrane and promotes nEGFR. …”
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    PGE(2)/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells
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