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1541por Xu, Bo, Long, Yu, Feng, Xueying, Zhu, Xujun, Sai, Na, Chirkova, Larissa, Betts, Annette, Herrmann, Johannes, Edwards, Everard J., Okamoto, Mamoru, Hedrich, Rainer, Gilliham, Matthew“…Here, we establish endogenous GABA as a bona fide plant signal, acting via a mechanism not found in animals. …”
Publicado 2021
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1542por Hofsetz, Eduard, Demir, Fatih, Szczepanowska, Karolina, Kukat, Alexandra, Kizhakkedathu, Jayachandran N., Trifunovic, Aleksandra, Huesgen, Pitter F.“…Based on the combination of altered processing patterns, protein accumulation and stabilization in CLPP-deficient mice and interaction with CLPP, we identified OAT, HSPA9 and POLDIP2 and as novel bona fide ClpXP substrates. Finally, we propose that ClpXP participates in the cooperative degradation of UQCRC1. …”
Publicado 2020
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1543por Wei, Hudie, Qu, Lingzhi, Dai, Shuyan, Li, Yun, Wang, Haolan, Feng, Yilu, Chen, Xiaojuan, Jiang, Longying, Guo, Ming, Li, Jun, Chen, Zhuchu, Chen, Lin, Zhang, Ye, Chen, Yongheng“…Overall, our current findings of the bona fide structure of p53/BCL-xL complex reveal the molecular basis of the interaction between p53 and BCL-xL, and provide insight into p53-mediated mitochondrial apoptosis.…”
Publicado 2021
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1544por Prokop, Jeremy W., Bupp, Caleb P., Frisch, Austin, Bilinovich, Stephanie M., Campbell, Daniel B., Vogt, Daniel, Schultz, Chad R., Uhl, Katie L., VanSickle, Elizabeth, Rajasekaran, Surender, Bachmann, André S.“…The linkage from the expression data of ODC1 in early neural progenitor proliferation to phenotypes of neurodevelopmental delay and to the connection of polyamine metabolites in brain function establish ODC1 as a bona fide neurodevelopmental disorder gene.…”
Publicado 2021
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1545por Chatterjee, Uday Sankar, Basu, Ashoke Kumar, Mitra, Debashis, Chatterjee, Subir Kumar“…In this study, we have tried to single out the bona fide responsible factor for the bad outcome; either the nonreversible kidney or the restenosis of pyeloplasty. …”
Publicado 2021
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1546por Rued, Britta E., Covington, Brett C., Bushin, Leah B., Szewczyk, Gabriella, Laczkovich, Irina, Seyedsayamdost, Mohammad R., Federle, Michael J.“…We determined that S. mutans UA159 possesses a bona fide short hydrophobic peptide (SHP)/Rgg quorum-sensing system that regulates a specialized biosynthetic operon featuring a radical-SAM (S-adenosyl-l-methionine) (RaS) enzyme and produces a ribosomally synthesized and posttranslationally modified peptide (RiPP). …”
Publicado 2021
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1547por Saavedra-García, Paula, Roman-Trufero, Monica, Al-Sadah, Hibah A., Blighe, Kevin, López-Jiménez, Elena, Christoforou, Marilena, Penfold, Lucy, Capece, Daria, Xiong, Xiaobei, Miao, Yirun, Parzych, Katarzyna, Caputo, Valentina S., Siskos, Alexandros P., Encheva, Vesela, Liu, Zijing, Thiel, Denise, Kaiser, Martin F., Piazza, Paolo, Chaidos, Aristeidis, Karadimitris, Anastasios, Franzoso, Guido, Snijders, Ambrosius P., Keun, Hector C., Oyarzún, Diego A., Barahona, Mauricio, Auner, Holger W.“…Using a transcriptome analysis pipeline, we further show that GCN2 is also a stress-independent bona fide target in transcriptional signature-defined subsets of solid cancers that share molecular characteristics. …”
Publicado 2021
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1548por Fan, Yuedan, Zou, Wenjuan, Liu, Jia, Al-Sheikh, Umar, Cheng, Hankui, Duan, Duo, Du Chen, Liu, Siyan, Chen, Luyi, Xu, Jilei, Ruhomutally, Firdosh, Kang, Lijun“…Mechanotransduction of OLL neurons might be carried by a novel Na(+) conductance channel, which is insensitive to amiloride. The bona fide mechano-gated Na(+)-selective degenerin/epithelial Na(+) channels, TRP-4, TMC, and Piezo proteins are not involved in this mechanosensation. …”
Publicado 2021
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1549por Kitamura, Yuka, Uranishi, Kousuke, Hirasaki, Masataka, Nishimoto, Masazumi, Suzuki, Ayumu, Okuda, Akihiko“…Germ cells alleviate its negative effect by reducing their amount of MAX, a component of PRC1.6, as a prerequisite for their bona fide meiosis. Here, we found that germ cells produced Mga variant mRNA bearing a premature termination codon (PTC) during meiosis as an additional mechanism to impede the function of PRC1.6. …”
Publicado 2021
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1550“…Recently, several extracellular matrix (ECM) proteins have been characterized as bona fide EV cargoes, exosomal secretion being particularly critical for TnC. …”
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1551por Joly, Etienne“…The hope is that these experiments will reveal a route of inoculation that can reliably lead to bona-fide infections, resulting in strong immune responses, with both cellular and serological components, but with much less viral replication in the lungs. …”
Publicado 2020
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1552por Fabretti, Francesca, Tschernoster, Nikolai, Erger, Florian, Hedergott, Andrea, Buescher, Anja K., Dafinger, Claudia, Reusch, Bjoern, Köntges, Vincent K., Kohl, Stefan, Bartram, Malte P., Weber, Lutz Thorsten, Thiele, Holger, Altmueller, Janine, Schermer, Bernhard, Beck, Bodo B., Habbig, Sandra“…Consistently, we found a transcriptional upregulation of bona fide YAP target genes. CONCLUSION: A comprehensive review of the here identified patients and those previously published indicates a highly diverse phenotype in patients with missense mutations but a more uniform and better recognizable phenotype in the patients with truncating mutations. …”
Publicado 2021
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1553por Wang, Xiangli, Fu, Yong, Beatty, Wandy L., Ma, Meisheng, Brown, Alan, Sibley, L. David, Zhang, Rui“…Using single-particle cryo-EM, we determine their ex vivo structure and identify three proteins (TrxL1, TrxL2 and SPM1) as bona fide microtubule inner proteins (MIPs). These three MIPs form a mesh on the luminal surface and simultaneously stabilize the tubulin lattice in both longitudinal and lateral directions. …”
Publicado 2021
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1554por Martínez-Gutiérrez, Alfredo, Fernández-Duran, Irene, Marazuela-Duque, Anna, Simonet, Nicolás G., Yousef, Ibraheem, Martínez-Rovira, Immaculada, Martínez-Hoyos, Josefina, Vaquero, Alejandro“…A two-step screening designed to identify compounds able to protect cells from UV-induced senescence through sirtuin activation identified shikimic acid (SA), a metabolic intermediate in many organisms, as a bona-fide candidate. The protective effects of SA against senescence were dependent on specific activation of SIRT1 as the effect was abrogated by the SIRT1 inhibitor EX-527. …”
Publicado 2021
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1555“…Despite many attempts, in vitro, de novo generation of bona fide HSCs remains challenging, and we are still far away from their clinical use, due to insufficient functionality and quantity of the produced HSCs. …”
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1556por Langhammer, Martina, Wytrwat, Erika, Michaelis, Marten, Schön, Jennifer, Tuchscherer, Armin, Reinsch, Norbert, Weitzel, Joachim M“…However, lifetime fecundity appears to be economically more important for the husbandry of many polytocous species for which mouse lines might serve as bona fide animal models (e.g. for pigs). In the present study, we compared the lifetime fecundities of two highly fertile mouse lines (FL1 and FL2: >20 offspring/litter at first delivery) with those of an unselected control line (ctrl) and two lines that were selected for high body weight (DU6) and high protein mass (DU6P) without selection pressure on fertility. …”
Publicado 2021
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1557por Melo, Joana, Pinto, Vanessa, Fernandes, Tânia, Malheiro, Ana R., Osório, Hugo, Figueiredo, Ceu, Leite, Marina“…Using this approach, a good yield of highly pure bona fide OMVs was recovered from cultures of different H. pylori strains and in different periods of bacterial growth, as assessed by nanoparticle tracking analysis, transmission electron microscopy (TEM), and proteomic analyses, confirming the reliability of the protocol. …”
Publicado 2021
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1558por Rodriguez-Calvo, Teresa, Christoffersson, Gustaf, Bender, Christine, von Herrath, Matthias G., Mallone, Roberto, Kent, Sally C., James, Eddie A.“…CD8(+) T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence that islet epitope reactive T cells are present within autoimmune lesions. These bona fide effectors have been a key research focus because these cells represent an intellectually attractive culprit for β cell destruction. …”
Publicado 2021
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1559por Opstelten, Rianne, Suwandi, Jessica S, Slot, Manon C., Morgana, Florencia, Scott, Andrew M, Laban, Sandra, Nikolic, Tatjana, Turksma, Annelies W, Kroeze, Anna, Voermans, Carlijn, Zwaginga, Jaap‐Jan, Roep, Bart O, Amsen, Derk“…GPA33(+) CD4(+) Tcm cells were fully undifferentiated, bona fide Tcm cells that lack immediate effector function, whereas GPA33(–) Tcm cells exhibited rapid effector functions and may represent an early stage of differentiation into effector/effector memory T cells before loss of CD62L. …”
Publicado 2021
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1560por Zheng, Jiashuo, Sato, Mami, Mishima, Eikan, Sato, Hideyo, Proneth, Bettina, Conrad, Marcus“…From these findings, we conclude that sorafenib does not qualify as a bona fide ferroptosis inducer and that ferroptosis induced by system x(c)(−) inhibitors can only be achieved in a fraction of tumor cell lines despite robust expression of SLC7A11, the substrate-specific subunit of system x(c)(−).…”
Publicado 2021
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