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  1. 1581
    “…HIF1α protein was completely destabilized with the onset of pulmonary ventilation, but did not coincide with expression changes in bona fide HRGs. We observed a modified composition of the HIF-PHD system from intrauterine to neonatal phases: Phd3 was significantly decreased, while Hif2a showed a strong increase and the Hif3a isoform Ipas exclusively peaked at P0. …”
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    Adaptation of the Oxygen Sensing System during Lung Development
  2. 1582
    “…In conclusion, TDMDfinder provides the first inventory of bona fide human and mouse TDMDs. Available as a free webtool, TDMDfinder allows users to search for any TDMD interaction of interest by customizing its selection criteria.…”
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    Prediction and pan-cancer analysis of mammalian transcripts involved in target directed miRNA degradation
  3. 1583
    por Devkota, Prajwal, Wuchty, Stefan
    Publicado 2022
    “…Notably, target genes of indispensable enhancer-binding TFs in cell-type specific regulatory networks were enriched with cancer drug targets, while target genes of indispensable promoter-binding TFs were bona-fide targets of cancer drugs in corresponding tissues. …”
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    Promoter/enhancer-based controllability of regulatory networks
  4. 1584
    “…Pull-down assay data revealed the physical interaction of CIGB-325 with viral nucleocapsid (N) protein and a group of bona fide CK2 cellular substrates. Our findings evidence in vitro antiviral activity of CIGB-325 against bovine coronavirus as well as some molecular clues that might support such effect. …”
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    Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection
  5. 1585
    “…We suggest that ABC1s are bona fide protein kinases with a unique regulatory mechanism. …”
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    The plastoglobule-localized protein AtABC1K6 is a Mn(2+)-dependent kinase necessary for timely transition to reproductive growth
  6. 1586
    por Tang, Jianing, Luo, Yongwen, Xiao, Liang
    Publicado 2022
    “…In the present study, we identified USP26, a DUB enzyme in the ubiquitin-specific proteases family, as a bona fide deubiquitylase of TAZ in ATC. USP26 was shown to interact with, deubiquitylate, and stabilize TAZ in a deubiquitylation activity-dependent manner. …”
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    USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ
  7. 1587
    “…This leads to the inaccurate depiction of the distances between the bona fide functional states. In particular, UMAP and t-SNE are not optimal to preserve the global geometric structure. …”
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    Supervised capacity preserving mapping: a clustering guided visualization method for scRNA-seq data
  8. 1588
    “…We show that the TAC toxin is a bona fide ribonuclease and identify exact cleavage sites in mRNA targets on a transcriptome-wide scale in vivo. mRNA cleavage by the toxin occurs after the second nucleotide of the ribosomal A-site codon during translation, with a strong preference for CCA codons in vivo. …”
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    Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis
  9. 1589
    “…OBJECTIVE: We surmised that pharmacological activation of PKA via intraperitoneal administration of Forskolin exerts anti-PD effects in symptomatic PTEN-induced kinase 1 knockout (PINK1-KO), a bona fide in vivo model of PD. METHODS: By using a beam balance and a grip strength analyzer, we show that Forskolin reverses motor symptoms and loss of hindlimb strength with long-lasting therapeutic effects (> 5 weeks) following the last dose. …”
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    Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats
  10. 1590
    “…BACKGROUND: ARID1A, a subunit of the switch/sucrose nonfermentable chromatin remodeling complex, has emerged as a bona fide tumor suppressor and is frequently downregulated and inactivated in multiple human cancers. …”
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    Evidence of histone modification affecting ARID1A expression in colorectal cancer cell lines
  11. 1591
    “…Combining viability assays, subcellular localisation studies, coimmunoprecipitation experiments and in vivo proximity labeling, we demonstrate that NONO-APEX2-HA is a stably expressed fusion protein that mimics endogenous NONO in terms of expression, localisation and bona fide interactors. We propose that in vivo proximity labeling in U2OS:NONO-APEX2-HA cells is capable for the assessment of NONO interactomes by downstream assays. …”
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    In vivo Proximity Labeling of Nuclear and Nucleolar Proteins by a Stably Expressed, DNA Damage-Responsive NONO-APEX2 Fusion Protein
  12. 1592
    “…Interestingly, AVIL is overexpressed in other sarcoma cells as well, and its expression correlates with clinical outcomes, with higher levels of AVIL expression being associated with worse prognosis. AVIL is a bona fide oncogene in RMS, and RMS cells are addicted to its activity.…”
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    Rhabdomyosarcomas are oncogene addicted to the activation of AVIL
  13. 1593
    “…These results identify UCKL-1 as a bona fide pyrimidine kinase with the therapeutic potential to be a target for tumor growth inhibition and for diminishing or preventing metastasis.…”
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    Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
  14. 1594
    “…Peroxiredoxin IV (Prx4) is an antioxidant with bona fide peroxidase and molecular chaperone functions. …”
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    Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways
  15. 1595
    “…The phylogeny showed FAP3 CHIs as an ancestral out-group positioned on the outer layers of the main branch, followed by type IV CHIs, which are placed in an evolutionary intermediate between FAP3 CHIs and bona fide CHIs (including type I and type II). The results imply a potential intrinsic evolutionary connection between CHIs existing in the green plants. …”
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    Genome-Wide Classification and Evolutionary Analysis Reveal Diverged Patterns of Chalcone Isomerase in Plants
  16. 1596
    por Tan, Yvonne, Buch, Maya H
    Publicado 2022
    “…This means D2T-RA comprises a heterogeneous population, with a proportion within this exhibiting bona fide treatment-refractory disease. The management points to consider, however, emphasise the importance of checking for the presence of inflammatory pathology before further treatment change. …”
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    'Difficult to treat' rheumatoid arthritis: current position and considerations for next steps
  17. 1597
    “…Moreover, we show the presence of bona fide intracellular persisters upon antibiotic treatment, which are metabolically active and retain the full infectious potential, therefore constituting a plausible reservoir for reinfection and relapse. …”
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    Antibiotic persistence of intracellular Brucella abortus
  18. 1598
    “…Mechanistically, we identified that XIAP is a bona fide target of miR-137, which is essential for miR-137-regulated sensitivity of TRAIL-induced cell death in GBM cells. …”
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    A miR-137-XIAP axis contributes to the sensitivity of TRAIL-induced cell death in glioblastoma
  19. 1599
    “…The target mRNAs of bona fide ATII miRNAs were used for pathway enrichment analysis. …”
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    microRNA Expression Profile of Purified Alveolar Epithelial Type II Cells
  20. 1600
    “…Here phosphoproteomics identified Ser775 in the microvillus protein Eps8 as a bona fide target of NleH1 and NleH2 phosphorylation. Both kinases interacted with Eps8 through previously unrecognized, noncanonical “proline-rich” motifs, PxxDY, that bound the Src Homology 3 (SH3) domain of Eps8. …”
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    Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli
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