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  1. 1601
    “…Overall, our study identifies PLAG1 as an enforcer of human HSC dormancy and self-renewal through its highly context-specific regulation of protein biosynthesis and classifies PLAG1 among a rare set of bona fide regulators of messenger RNA translation in these cells. …”
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    PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal
  2. 1602
    “…Here we study primary-active transport via P-type ATPases using functional and structural analyses to demonstrate that four simultaneous residue substitutions transform the non-gastric H(+)/K(+) pump, a strict H(+)-dependent electroneutral P-type ATPase, into a bona fide Na(+)-dependent electrogenic Na(+)/K(+) pump. …”
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    Structure and function of H(+)/K(+) pump mutants reveal Na(+)/K(+) pump mechanisms
  3. 1603
    “…Here we employed in vivo co-purification of tRNAs with endogenously expressed nuclear exporters to document that Crm1 also is a bona fide tRNA nuclear exporter. We document that Los1, Mex67-Mtr2 and Crm1 possess individual tRNA preferences for forming nuclear export complexes with members of the 10 families of intron-containing pre-tRNAs. …”
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    Three tRNA nuclear exporters in S. cerevisiae: parallel pathways, preferences, and precision
  4. 1604
    por Munthe, Christian
    Publicado 2021
    “…This leaves the notion of running bona fide controlled trials of entire TGM concepts that have been justified from the perspective of clinical and research ethics (and approved by IRBs). …”
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    The ethics of resource allocation in translational genomic medicine
  5. 1605
    “…Viruses are now recognized as bona fide etiologic factors of human cancer. Carcinogenic viruses include Epstein– Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell leukemia virus type 1 (HTLV-1), human immunodeficiency virus type 1 (HIV-1, indirectly), and several candidate human cancer viruses. …”
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    Murine Models of Chronic Viral Infections and Associated Cancers
  6. 1606
    “…With the increase in malnutrition, diet related non-communicable diseases and poverty across the continent of Africa, the spider plant is a bona fide alternative healthy food crop to alleviate these challenges. …”
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    Cleome gynandra: A wonder climate-smart plant for nutritional security for millions in semi-arid areas
  7. 1607
    “…Conversely, we confirmed that SHP-1, Synaptotagmin XI, VAMP8, and Syntaxin-5 are bona fide GP63 substrates. These results point to the importance of efficiently inhibiting GP63 activity during the preparation of Leishmania-infected host cell lysates. …”
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    Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates
  8. 1608
    “…Given that marine phage satellites cannot be distinguished from bona fide viral particles via commonly used microscopic techniques, their predicted numbers (∼3.2 × 10(26) in the ocean) may influence current estimates of virus densities, production, and virus-induced mortality. …”
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    Marine viral particles reveal an expansive repertoire of phage-parasitizing mobile elements
  9. 1609
    “…In mouse and human, AF(+) macrophages from perilesional skin and cSCC are highly phagocytic cells contrary to their AF(-) counterpart, thus identifying autofluorescence as a bona fide marker for phagocytosis. Our data bring to light autofluorescence as a functional marker characterizing subsets of phagocytic macrophages in skin and cSCC. …”
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    Autofluorescence identifies highly phagocytic tissue-resident macrophages in mouse and human skin and cutaneous squamous cell carcinoma
  10. 1610
    “…Mechanistically, LINC02551, a bona fide m(6)A target of ALKBH5, acted as a molecular adaptor that blocked the combination between DDX24 and a E3 ligase TRIM27 to decrease the ubiquitination and subsequent degradation of DDX24, ultimately facilitating HCC growth and metastasis. …”
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    ALKBH5-mediated m(6)A modification of lincRNA LINC02551 enhances the stability of DDX24 to promote hepatocellular carcinoma growth and metastasis
  11. 1611
    “…Results: The Sotos syndrome-specific DNAm signature was validated in six individuals with a clinical diagnosis of Sotos syndrome and carrying bona fide pathogenic NSD1 variants. Applying this approach to the remaining 11 individuals with NSD1 variants, we succeeded in confirming pathogenicity in eight subjects and excluding the diagnosis of Sotos syndrome in three. …”
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    Genome-Wide DNA Methylation Profiling Solves Uncertainty in Classifying NSD1 Variants
  12. 1612
    “…Proteins in this AntiFam entry indeed seem likely to be bona fide proteins, based on additional considerations, and thus AlphaFold provides a useful quality control for the AntiFam database. …”
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    Folding the unfoldable: using AlphaFold to explore spurious proteins
  13. 1613
    “…Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian cells. …”
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    Membrane curvature governs the distribution of Piezo1 in live cells
  14. 1614
    “…Overall, our findings reveal an essential role of WWOX in pancreatic cancer development and progression and underscore its role as a bona fide tumor suppressor.…”
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    Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling
  15. 1615
    “…Clinical management of endometrial cancer (EC) is handicapped by the limited availability of second line treatments and bona fide molecular biomarkers to predict recurrence. …”
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    Generation and Integrated Analysis of Advanced Patient‐Derived Orthoxenograft Models (PDOX) for the Rational Assessment of Targeted Therapies in Endometrial Cancer
  16. 1616
    “…Recently, we identified L3MBTL3 as a bona fide RBPJ-binding corepressor that recruits the repressive lysine demethylase LSD1/KDM1A to Notch target genes. …”
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    The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3
  17. 1617
    “…This identified GRAMD1B, a cholesterol transfer protein, as a bona fide metastasis suppressor, with a majority of knockout animals rapidly developing metastasis. …”
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    Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
  18. 1618
    “…In conclusion, recombinant Amb a 11 is a bona fide allergen, which is IgE-reactive and an inducer of hRBL degranulation. …”
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    Ragweed Major Allergen Amb a 11 Recombinant Production and Clinical Implications
  19. 1619
    “…Surprisingly, a majority of ICKs tested also possess the CPC clip motif, including 75 bona fide plant and arthropod knottin proteins that share high sequence and/or structural similarity with LhKNOT. …”
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    In Silico Analysis of a Drosophila Parasitoid Venom Peptide Reveals Prevalence of the Cation–Polar–Cation Clip Motif in Knottin Proteins
  20. 1620
    “…Indeed, CP is highly unstable and a bona fide substrate of SEL1L-HRD1 ERAD. In the absence of ERAD, CP protein accumulates in the ER and is shunted to refolding, leading to elevated secretion. …”
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    Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin
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